Doctors Best - Best Tocotrienols 125 mg. 30 Softgel Capsules
Doctors Best contains Tocotrienols which are important, yet often overlooked, members of the vitamin E family, which also includes the tocopherols. Tocotrienols are superior antioxidants to the tocopherols, with delta-tocotrienol being the most potent of all tocotrienols. DeltaGold Tocotrienols derived from annatto seeds contain approximately 90% delta- and 10% gamma-tocotrienols. Tocotrienol studies have shown powerful cardiovascular support. Tocotrienols support the health and function of arteries and veins, while promoting healthy circulation. Research also suggests that tocotrienol supplementation maintains cholesterol levels already within the normal range.
- Science-based nutrition
- Dietary supplement
- Helps maintain cholesterol levels that are already in the normal range
- Powerful cardiovascular wellness support
- Maintains healthy circulation
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Natural vitamin E is a mixture of four tocopherol compounds (alpha, beta, delta and gamma) and four tocotrienol compounds (alpha, beta, delta and gamma).While alpha-tocopherol is the most well-known and best-studied compound in the vitamin E family, tocotrienols are quickly gaining attention in the research world for their beneficial actions as antioxidants and as nutrients that support cardiovascular and neurological health.
Numerous foods such as grains, nuts and seeds contain tocotrienols; however, palm oil, rice bran oil, and annatto seeds are especially rich in these compounds. Annatto, or Bixa orellana L, is a shrub that is native to tropical South America. Aside from containing tocotrienols, the seeds are also rich in several yellow/orange carotenoid pigments, hence the seeds have been consumed for hundreds of years as a spice and used as a dye, as well as for other medicinal uses. Today, extracts of the seed are used commercially as a natural color additive for foods and cosmetics. The annatto seed is unique in that the majority of its tocotrienol content is in the form of delta-tocotrienol, which has been shown to have especially beneficial effects related to maintaining health, including antioxidant effects and cardiovascular benefits.
DeltaGold Tocotrienols from annatto seeds contain approximately 90% delta-tocotrienol, and are free of tocopherols. This is advantageous, as taking tocopherols at the same time as tocotrienols may counteract some of the beneficial properties of tocotrienols.
Potent Antioxidant Effects
The presence of antioxidants in the body is necessary for optimal health. Free radical compounds form constantly within the body, either during metabolism or through environmental exposures. Antioxidants counteract the often-deleterious effects of these compounds by absorbing dangerous unpaired electrons called free radicals. Tocotrienols are fat-soluble antioxidants, and work in part by preventing oxidation of the fat-containing cellular membranes and lipoproteins. While all vitamin E compounds have important antioxidant activity, research suggests that tocotrienols may have stronger antioxidant biological effects than tocopherols and that delta-tocotrienols may be the most potent antioxidant of the tocotrienols.
Helps Maintain Cholesterol Levels that are Already in the Normal Range
The effects of tocotrienols have been evaluated in many human clinical trials, and these compounds are known to powerfully support the cardiovascular system through several mechanisms. The studies have varied in length from weeks to years, and the number of subjects in some of the studies was 50 or more.
The strong antioxidant properties of tocotrienols are thought to be extremely advantageous to the health of the vascular system. In addition to these antioxidant benefits, tocotrienols healthfully support normal cholesterol biosynthesis by modulating enzymatic processes related to cholesterol production in the liver. By supporting cholesterol homeostasis, tocotrienols can help to maintain cholesterol levels that are already in the normal range .
A study published in 2002 by Qureshi and colleagues consisted of 90 individuals who were placed on a low fat diet for five weeks. Tocotrienols were then supplemented at concentrations of 25, 50, 100 or 200 mg per day for another five weeks. The initiation of the low fat diet by itself had beneficial effects on a number of markers of cardiovascular health in the subjects. However, when the tocotrienols were combined with the low fat diet, the beneficial effects were much greater. The dose of tocotrienols that produced the optimal healthful effects in this study was 100 mg per day. The authors noted enhancements in several measures of cardiovascular wellness with the intake of tocotrienols. Similar results were reported in a study published a year earlier by the same author. This study also assessed, the effects of tocotrienol intake in combination with a low fat diet.
When the four tocotrienol compounds were tested individually for their effects in animals, delta-tocotrienol had the most profound effect related to the maintenance of healthy cholesterol levels. Supplementation with tocotrienols by themselves appears to be more beneficial than supplementation with tocotrienols combined with tocopherols, the latter of which appear to diminish the beneficial effects of the former.
Several human clinical studies have shown that tocotrienols can also protect the structural integrity and function of the artery walls,5,10,15 a benefit that, along with healthy lifestyle choices, can help to maintain a youthful and healthy cardiovascular system. In a study of 50 subjects, significant cardiovascular health benefits were observed in the population taking tocotrienols as compared to those taking placebo. Of the several markers observed, one included a statistically significant benefit related to the structure of the carotid arteries.