Free Shipping On All Metagenics Items!

Automatically receive free standard shipping with purchase of Metagenics products. $10 minimum purchase required. US addresses only.

Metagenics - Estrovera - 90 Tablets
  • View image
  • View image
  • Ingredients
  • Gluten-Free

    Excludes any ingredient that is a gluten-containing grain including wheat, barley, rye and triticale.

  • Vegetarian

    Excludes all meat products and any meat derivatives, but can include eggs, dairy and other animal-sourced foods.

Metagenics - Estrovera - 90 Tablets

with Siberian Rhubarb
Item #: 135632
$109.19 Per Serving: $1.21
Serving Size: 1 Tablet(S)Free Shipping on Professional Supplements Details
Qualifies for Free Shipping
545 Points Lucky Rewards open

In Stock

Ships within 24 hours
Print this

Metagenics - Estrovera - 90 Tablets

  • Item# :135632
    UPC# :755571936486
  • Brand:Metagenics
  • Size/Form:90  Tablets
  • Ship Weight:0.10
  • Servings:90
  • Dosage:1  Tablet(S)

Metagenics - Estrovera - 90 Tablets

Metagenics Estrovera is and extensively researched, natural approach for hot flash relief. It contains an exclusive phytoestrogenic extract of rhapontic (Siberian) rhubarb root known as ERr 731 that has been suggested to be comparable in effectiveness to an ultra low dose of conventional hormone therapies . This extract has also demonstrated significant reductions in other common menopausal symptoms and is effective in just 4 mg daily—with noticeable results in just 4 weeks. Like any successful approach to managing menopausal symptoms, Estrovera is recommended in conjunction with simple lifestyle modifications and healthy habits for optimal outcomes. Women can tailor these suggestions according to their unique menopausal experience.

Estrovera is a natural option demonstrated in clinical studies to significantly reduce menopausal hot flashes compared to placebo. These results are comparable to hormone therapies. Clinically shown to dramatically reduce the number of daily menopausal hot flashes. Clinically demonstrated to relieve a wide range of other menopausal symptoms including:

  • Sleep disturbances
  • Poor mood, irritability, and anxiety
  • Physical and emotional exhaustion
  • Heart complaints (e.g., racing)
  • Joint and muscle complaints
  • Urinary tract symptoms
  • Vaginal dryness and sexual problems


What is Estrovera?
Estrovera is a nutraceutical that contains a unique phytoestrogenic extract of a garden rhubarb species that has been recommended in Germany for menopausal complaints since 1993. This extract, referred to in research as ERr 731™, was introduced in 2009 to the United States and is available exclusively from Metagenics. Estrovera contains the first phytonutrient compound shown in well-designed clinical studies to offer effective hot flash reduction similar to conventional hormones therapies, but without the associated risks or other serious adverse events. Estrovera's main active ingredient has also demonstrated significant improvements in common menopausal complaints—such as poor mood, anxiety, and sleep quality—as well as additional measures of quality of life and general health and well-being

Will Estrovera relieve my menopausal hot flashes? And how does it compare to hormone therapies (HT)?
Estrovera offers fast and effective hot flash relief with only 1 tablet daily. Estrovera's active ingredient (ERr 731) is perhaps the only natural approach shown to provide consistent and significant symptom reduction comparable to conventional HT—without the associated risk of serious adverse effects. In a double-blind, placebo-controlled clinical study of perimenopausal women, ERr 731 was shown to relieve moderate and severe hot flashes after only 4 weeks (a study measurement point); the frequency and intensity of hot flashes were further decreased at 8 and 12 weeks. In another double-blind, placebo-controlled clinical study, the efficacy of ERr 731 was confirmed with a statistically significant, average reduction in hot flash frequency from 12 to 2 daily. A comparison of hot flash weekly weighted scores from this study suggests that the effectiveness of ERr 731 is comparable to that of an ultra low dose of HT.

How does Estrovera compare to other natural approaches for menopausal hot flash relief?
Due to a lack of well-controlled studies for many natural approaches, including other phytoestrogens, it's difficult to make a comparison. ERr 731 appears to represent a more effective approach than soy, black cohosh, red clover, hops, and flax lignans (to name just a few) that are currently recommended for hot flash relief. Research to date suggests that ERr 731 may be the first phytoestrogen extract to transcend the placebo effect in clinical studies with menopausal women to offer a higher degree of effectiveness with minimal safety concerns for long-term use.

Is Estrovera use recommended for perimenopausal and postmenopausal women?
Yes. Unlike conventional hormone therapies, Estrovera's main ingredient has been demonstrated as a safer approach for perimenopausal women. The predicted safety profile for ERr 731 suggests safe use through postmenopause until symptoms dissipate.

How do I take Estrovera?
Take 1 tablet daily with breakfast and a glass of water or as directed by your health care practitioner.

Do I need a stronger dose for more severe symptoms?
Because positive clinical outcomes have been seen at varying intensities of hot flashes at the 4 mg dose, higher doses are not recommended. In fact, women with greater symptomatology in clinical studies reported the greatest benefit, yet did not exceed the recommended dosage. Follow all health care provider recommendations for the dosage of any product, natural or otherwise.

How quickly will I notice improvement?
It may take up to 4 weeks for you to notice sustained improvement. Daily supplementation with Estrovera for a minimum of 3 months is suggested to ensure better outcomes, or as your practitioner recommends. You may also benefit from keeping a weekly hot flash diary to help them track Estrovera's effectiveness, as well as to identify eating and lifestyle habits that may also trigger symptoms (e.g., spicy foods, vigorous exercise, heated rooms, and stressful situations).

What makes Estrovera unique?
Estrovera contains a novel extract from the root of rhapontic or Siberian rhubarb (Rheum rhaponticum L.). This extract contains natural bioflavonoid compounds (primarily rhaponticin) that are similar to resveratrol and may work collectively to offer menopausal symptom relief. The effectiveness of this extract has been confirmed with well-designed, placebo-controlled clinical studies.

How does Estrovera work?
Like many popular approaches for menopausal symptom relief, the exact mechanism of action is not yet clear. (And neither is the exact cause of hot flashes.) ERr 731 has been shown in vitro to exhibit selective estrogen receptor modulator (SERM) properties, primarily as an agonist of estrogen receptor-ß, which has been suggested as a possible mechanism of action for observed menopausal symptom relief. Furthermore, the root of Rheum rhaponticum naturally contains significant amounts of the antioxidant flavonoid quercetin, which suggests that ERr 731 may also protect against oxidative stress that contributes to menopause and other age-related complaints.

Are Estrovera's ingredients safe?
Estrovera's novel rhubarb extract has an excellent predicted safety profile. ERr 731 has been reviewed by the FDA as a new dietary ingredient and has been dispensed in Germany since 1993 with over 60 million doses to date. ERr 731 and its individual components have been evaluated via in vitro to exhibit predictably safe activity in endometrial and bone cell lines. In vivo toxicity studies have demonstrated no significant effects in clinical observations, blood tests, microscopic findings, and other standard toxicology measures (including those of the uterus). Safety has been further demonstrated through well-designed clinical studies with over 400 patients that include 1- and 2-year evaluations for long-term efficacy. These clinical studies have shown no clinically relevant changes in endometrial biopsies, bleeding, weight, blood pressure, pulse, or other standard laboratory parameters. No serious adverse events associated with ERr 731 use have been reported to date.

Does Estrovera have any serious adverse events?
Estrovera's active ingredient, ERr 731, is well tolerated. There have been no serious reported adverse effects associated with ERr 731 supplementation in clinical studies (lasting up to 2 years), in vivo studies, and clinical experience with more than 60 million doses since 1993. Mild and transient symptoms suspected to be related to ERr 731 (e.g., headache) intake have been observed to dissipate after discontinuation.

Who should NOT take Estrovera?
Due to lack of safety studies, Estrovera supplementation is not recommended for use during pregnancy, if you are planning to get pregnant, or while nursing. Like other supplements containing natural selective estrogen receptor modulator (SERM) compounds (phytoestrogens), Estrovera should be avoided in individuals with endometriosis and known or suspected hormone?sensitive cancer(s), as the effects on cell lines associated with these diseases are not known. Should Estrovera be combined with any other therapy to see positive results? Because lifestyle factors (e.g., diet, exercise, stress, smoking, alcohol, caffeine, body mass index) can increase the intensity of symptoms, health authorities suggest that a healthier lifestyle greatly contributes to the success of any menopausal approach. Your doctor may recommend Estrovera as part of a comprehensive lifestyle protocol specific to menopausal women. Furthermore, in addition to mineralization support for bone protection (e.g., calcium, magnesium, and other minerals), postmenopausal women may also need nutritional support for bone remodeling, which is also influenced by estrogen decline.

Are there benefits to taking Estrovera long term?
Estrovera's phytoestrogenic extract has been investigated in 4 published clinical studies lasting up to 2 years that demonstrate continuing benefit with regular use. Because the extract components are rapidly metabolized within hours of intake, they do not stay in the body to offer residual benefits after intake is halted or missed. Symptoms such as hot flashes reportedly increase a few days after discontinuation, suggesting that daily intake is crucial for sustained relief.

Why does Estrovera need to be enteric-coated?
The bioflavonoid compounds in Estrovera break down rapidly. The enteric coating therefore prevents the tablet from premature breakdown in the stomach, ensuring that all the potentially active ingredients are delivered to the small intestine for optimal use. The inactive ingredients used in the enteric coating are approved for use in dietary supplement manufacturing and enhance the delivery of Estrovera's natural active ingredients without compromising its predicted safety profile.

About Metagenics
Today, chronic health conditions such as high blood pressure, obesity, diabetes, and heart disease have become so common that most people don't remember what it's like to be in excellent health. And if they're not feeling their best, they can't be their best. In truth, many chronic health conditions are preventable. They're the result of years of poor eating habits, lack of exercise, and prolonged exposure to stress. And leading health organizations now tell us that by returning to a healthier lifestyle-by getting the right nutrients, becoming active, and learning to manage the stressors in life-many of these conditions can be prevented, managed, or even reversed. The solution seems so simple, and yet, the incidence of chronic illness is continuing to rise at an alarming rate. At Metagenics, they're aiming to change all that.

Addressing Chronic Illness with Therapeutic Lifestyle Changes
Their groundbreaking therapeutic lifestyle change (TLC) programs have helped tens of thousands of chronic illness sufferers all over the world regain their health-so they can once again enjoy their lives to the fullest. Not quick, short term fixes, these programs work because they're focused on helping people develop healthy, life-long habits that they can easily incorporate into their busy schedules. Their TLC programs are available only from specially trained licensed health care professionals-the people qualified to recommend and tailor a regimen that's unique to each individual's needs.

Patient Success Depends on Provider Success
Let's face it. Most doctors' offices have neither the time nor the expertise to provide the individualized lifestyle counseling that's necessary to effect real change. In designing their TLC program, they asked health care providers to tell us what it would take to implement TLC successfully in their practice. The answer was teamwork-getting support staff involved, enlisting practice extenders and ensuring smooth office flow. Today, providers who implement their TLC programs overwhelmingly report that they're busier and more successful than ever in helping patients achieve their desired health outcomes.

Addressing the Root Cause of Illness through Science-Based Nutrition
Back in 1983, they had a big idea: the right nutrition could help people realize their best health possible by positively influencing what makes them unique-their genes. They called it realizing "genetic potential" for good health. Today, it's known as the science of nutrigenomics-the study of food as one of the most important environmental modifiers of gene expression in determining health and disease patterns. Through their substantial and ongoing commitment to nutrigenomic research, they've been able to identify natural compounds with powerful therapeutic applications, to be used in their science-based TLC programs, medical foods, and nutraceuticals.

Setting the Standard in Research, Quality & Innovation
Knowing that professionals rely on us to make people feel better isn't something they take lightly. It's the reason they lead the industry in research, professional education, and quality manufacturing. But they're also brave enough to search for the next big thing to make an even greater impact on health. The result? An impressive list of patented formulas and ingredients, and a revolutionary product development process to help make natural approaches even safer and more effective.

ake 1 tablet daily with breakfast with a glass of water. The tablet should be taken at the same time each day or as directed by your healthcare practitioner.

Metagenics - Estrovera - 90 Tablets
Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 90
Amount Per Serving %DV
Rhapontic Rhubarb (Rheum rhaponticum L.) Root Extract 4mg (providing 2.2mg rhaponticin and 1mg desoxyrhaponticin)  *
*Daily Value Not Established.
†Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
Other Ingredients: Microcrystalline cellulose, stearic acid (vegetable), croscarmellose sodium, silica, enteric coating (deionized water, cellulose acetate phthalate, glycerol triacetate, ammonium hydroxide, hypromellose, maltodextrin, and polyethylene glycol)

Do not use if pregnant or nursing, or if you have endometriosis. This product is contraindicated for individuals with known or suspected hormone-sensitive cancer(s). If taking medication(s), consult your healthcare practitioner before use.

25 Enterprise STE 200
Aliso Viejo, CA,
Phone: (800)692-9400 Email: Click here Visit website

About Metagenics

Metagenics™ helps people live happier, healthier lives by realizing their genetic potential

Metagenics™ was founded in 1983 on a brave new scientific concept: how the right nutrition could help people realize their best health possible by influencing what makes them unique—their genes. Back then Metagenics™ called it “genetic potential through nutrition.” It also makes them unique—it’s been their mission and a key differentiator ever since.

Today, this ever-growing and respected field of science is known as nutrigenomics. And it's been practiced for nearly 30 years by forward-thinking providers who utilize Metagenics™ industry-leading products and programs to help people live healthier, happier lives.

Now healthcare organizations worldwide recommend “lifestyle medicine” to improve health with basic nutrigenomic tenets: healthier eating and regular exercise. But Metagenics™ holds the key to making lifestyle medicine programs more effective, as well as more expedient with targeted nutritional support.

Metagenics™ research-based medical foods, nutraceuticals, and turnkey programs help address each patient’s unique health needs for a higher level of personalized, lifetime wellness care. That’s why so many healthcare providers worldwide trust Metagenics™ over any other professional brand.

LuckyVitamin is not owned or operated by Metagenics™, INC.

Average Rating

2 rating(s)4 out of 5 stars
  • 5 stars
  • 4 stars
  • 3 stars
  • 2 stars
  • 1 star


100%2 out of 2 reviewers would recommend this product to a friend.
Bought this product? write a review

By (Calgary , Alberta )

This product has really helped me with my hot flashes & I do believe I am sleeping a bit better

Was this review helpful?Yes0No0Thank you for your response.

By (Ashburn , VA )

My doctor recommended this formula for me; I prefer a holistic approach to not just treating symptoms, but also addressing the causes of 'ailments', whether natural occurrences or not, and all with few or preferably no conventional chemical meds. Extrovert worked for me, immediately, and what a relief! I recommend it to anyone with symptoms of 'the change'.

Was this review helpful?Yes0No0Thank you for your response.

Disclaimer: The views and opinions expressed by contributors of the product reviews are their own and not necessarily those of LuckyVitamin.com. LuckyVitamin.com does not endorse or imply any medical claims from these reviews. These reviews should not be taken as recommendations but rather customer opinions of the products that they may or may not have used. Reviews are not intended as a substitute for appropriate medical care or advice and are not intended to diagnose, treat, cure, or prevent any disease. Read the full product reviews disclaimer here.

Listings For This Product

Back to top

Related Searches

Back to top


Back to top
*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.