Douglas Laboratories Bone CoFactors Osteo Support - 180 Capsules
Douglas Laboratories Bone CoFactors is formulated to provide the necessary vitamins and minerals combined with a milk protein called MBP that helps to support bone strength. MBP has the distinctive function of balancing osteoblast and osteoclast activity, which complements the function of other nutrients in Douglas Laboratories Bone CoFactors for optimized bone health. Douglas Laboratories Bone CoFactors is a dietary supplement indicated for individuals that require the nutrients necessary for healthy bone strength and metabolism.
Bones are constantly being remodeled, not only during the growth stages, but also into adulthood. This process of bone turnover involves two types of cells: osteoblasts and osteoclasts. Osteoblasts promote bone formation and create collagen, so that calcium can effectively adhere to the collagen and create new tissue. Osteoclasts destroy old bone tissue by releasing acid and enzymes to dissolve calcium and collagen. However, osteoclasts can become excessive due to hormonal imbalances and other factors, leading to calcium deficiency in the bone. Therefore, nutrients that suppress excess osteoclast activity and support
osteoblast activity are important to the health of the bones.
MBP is a milk protein that is found in human and bovine milk. It is a highly bioactive fraction of total milk protein content that has been clinically shown to support the formation of healthy bones. Unlike other bone substances such as Vitamin K, MBP increases the number of bone-forming osteoblast cells and regulates the activity of bone-destroying osteoclast cells (see chart, page 2). Therefore, MBP is a multifunctional protein that functions by acting directly and/or indirectly on bone cells to promote the bone formation, while at the same time inhibiting excess bone destruction, called bone resorption. Because bone metabolism proceeds at an extremely gradual pace, it may take 3 to 6 months or longer to notice improved bone metabolism with
supplementation. In a study conducted with 33 healthy adult women, BMD (bone mineral density) increased by 3% in the control group after 6 months of ingesting 40 mg of MBP™ daily. Another clinical study performed with 32 post-menopausal women consuming MBP daily for 6 months, the mean lumber BMD significantly increased and Urinary cross-linked N-telopeptides (NTx) of type I collagen were significantly decreased, resulting in positive bone metabolism.
Calcium supplementation through dietary sources and supplementation is important for bones, but it is merely the material used to form bones. It is osteoblasts that actually form bones. Therefore, no matter how much calcium one ingests, if bones are not receptive to the calcium, it isn’t fully incorporated into the bones. MBP can help the body utilize the calcium ingested. Vitamin D helps to facilitate calcium absorption and transport. Vitamin D can increase the expression of osteocalcin and other important compounds from osteoblasts to help support bone formation; it can also help to breakdown bone and mobilize calcium to other tissues in the body. Numerous scientists now feel that supplementation with vitamin D at levels greater than previously thought necessary is critical to helping maintain healthy bone remodeling as we age.
Vitamin K2 is not commonly found in the diet. Human studies show that vitamin K plays important roles in bone health; it has been shown to decrease calcium excretion and is involved in gamma-carboxylation of osteocalcin. Osteocalcin, a protein found in the extracellular bone matrix is important for healthy bone formation as it facilitates the carrying of calcium out of blood vessels and binding it to hydroxyapatite (bone matrix). Vitamin K2 (as menaquinone-7) is more bioactive and has proven more effective than vitamin K1 and other menaquinones. Furthermore, the study showed better utilization and improved osteocalcin carboxylation for MK-7 after 6 weeks.
Calcium Microcrystalline Hydroxyapatite provides a highly beneficial source of dietary calcium together with other naturally occurring nutrients like phosphorus, amino acids, glycosaminoglycans that assist in the maintenance of healthy bone structure and function.Boron affects the composition, structure, and strength of bone. It appears to be necessary for calcium and magnesium absorption, their adequate renal reabsorption, and their incorporation into the bone matrix. Magnesium is a mineral that is important for normal bone structure, and plays an essential role in more than 300 cellular reactions. New research shows magnesium homeostasis is helpful for maintaining bone integrity. Vitamin D and parathyroid hormone are essential for
Trace minerals such as zinc, manganese and copper are also important for bone health. Some clinical research suggests that taking copper in combination with zinc, manganese, and calcium may support healthy bone metabolism in postmenopausal women. Low serum zinc levels have been associated with low bone mineral density.
About Douglas Laboratories
Back in 1955, Sam Lioon, founded Douglas Laboratories on a simple promise: provide the highest quality nutritional supplements available with the highest level of personal service—anywhere. And with that promise began a legacy of leadership—and a never-ending quest to exceed their customers' expectations to Raise the Standard for Nutrition and Wellness.
Today that legacy lives on as Douglas Laboratories proudly joins the Atrium Innovations group of companies. Atrium Innovations is an international company and global leader in the development, manufacturing, and marketing of dietary supplements, specialty fine chemicals, and active cosmetic ingredients.
Douglas Laboratories is supported by more than 300 Douglas Laboratories employees all dedicated to keeping the promise Sam made 50 years ago. Raising the Standard is more than a slogan—it's a promise. As they enter their second half-century, Douglas Laboratories will continue to keep their promise to Raise the Standard with a custom approach to their patients' nutrition and wellness. With custom formulations their patients can't find anywhere else. Custom labels. Custom daily packs. And the industry's largest and most innovative product line. And they'll back up their promise with the kind of stringent criteria many other companies overlook, such as:
- (cGMPs) current good manufacturing practices.
- ISO 9001 Certification and ISO 17025 Accreditation of their laboratories.
- The industry's first fully electronic, bar code driven, paperless manufacturing system to pass the FDA's rigorous audit. Their exclusive Veri-Match labeling system, ensures verification prior to production and release of their products.
- (SOPs) standard operating procedures.
- VCP (Vendor Certification Program) ensures raw material safety and quality.
- Experienced, on-staff Ph.D's, utilizing three full-service laboratories, outfitted with the latest analytical equipment.
- State-of-the-art manufacturing, including ultra high-speed encapsulating machines, capable of producing over 35 million capsules and tablets daily!
- Full compliance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002, assuring safety and uninterrupted flow of all raw materials.
Douglas Laboratories continues to lead the way with clinical trials designed to validate the efficacy of their products. Their world-renowned Ultra-Preventive X (Ten) was rated the #1 multivitamin in the professional healthcare market, and their Vita-Big-Kids was rated the #1 children's multivitamin overall by the independent Comparative Guide to Nutritional Supplements. Their commitment to help support patient outcomes is ongoing; look for their new in-office patient education posters, easy online ordering from their website and more innovative ideas designed to help their practice grow in the days ahead.
But most of all, they're proud of the many long-standing relationships they've enjoyed with so many customers over the years, and the many great friendships they've made along the way. It's not an exaggeration to say that they truly enjoy what they do, enjoy coming to work each and every day.
Trust Douglas Laboratories for a partnership founded on a heritage of excellence. For more than 50 years, they have been at the forefront of the nutritional health industry, proudly researching, developing and manufacturing superior-quality, science-based dietary supplements to help people improve their health. Proudly earning the trust of thousands of healthcare professionals.
Trust Douglas Laboratories for best-in-class, science-based dietary supplements manufactured exclusively for healthcare professionals. They are proud to offer one of the largest and most innovative selections of over 600 premium-quality products and a comprehensive range of galenic forms (dosage and delivery), manufactured at GMP-compliant, state-of-the-art facilities.