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Umbrellux DAO Histamine Neutralizing Enzyme 10,000 HDU - 60 CapsulesDiem Labs

Item #: 187769
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Diem Labs - Umbrellux DAO Histamine Neutralizing Enzyme 10,000 HDU - 60 Capsules
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1 Capsule(s)


    Diem Labs - Umbrellux DAO Histamine Neutralizing Enzyme 10,000 HDU - 60 Capsules

    Umbrellux DAO is the original diamine oxidase (DAO) supplement brand in the US. DAO is the primary enzyme responsible for the breakdown of histamine in the digestive tract. Umbrellux DAO is indicated for those with intolerance to dietary histamine, histamine sensitivity, and occasional digestive distress related to histamine-containing foods and beverages.

    Umbrellux DAO delivers naturally derived diamine oxidase to the small intestine, where it acts directly on dietary histamine to defend against histamine-related reactions and digestive discomfort.

    Histamine Intolerance is Real - Umbrellux DAO supplement can help.
    Many foods and beverages contain histamine. Some trigger the release of histamine in the gut. Individuals who are sensitive or intolerant to dietary histamine react in a number of ways, from digestive disturbances to sneezing and congestion, red/watery eyes, flushed skin, even hives and headache.

    Symptoms of Histamine Intolerance

    • Vasodilation (flushing/reddening)
    • Hypotension/Tachycardia
    • Stuffy, Runny Nose/Sneezing
    • Swelling or red, watery eyes
    • Headache or Migraine
    • Diarrhea, cramps, bloating
    • Feelings of anxiety
    • Urticaria (hives)

    Histamine-Rich Foods

    • Chocolate
    • Cheese (all types, especially aged)
    • Sauerkraut
    • Tuna
    • Aged, cured, process and fermented
    • Meats (pepperoni, sausage, bacon)
    • Tomatoes/Ketchup
    • Vinegar (all types)
    • Alcoholic beverages
    • Shellfish
    • Avocado
    • Bananas
    • Eggplant

    Histamine Liberators

    • Berries (especially strawberries)
    • Alcoholic Beverages
    • Milk and dairy products
    • Citrus fruits
    • Bananas
    • Chocolate
    • Shellfishes

    DAO Enzyme-Inhibiting Drugs

    • Acemetacin
    • Acetylcysteine
    • Adalimumab (Humira)
    • Amitriptyline
    • Antihistamines
    • Aspirin
    • Diazepam
    • Duloxetine (Cymbalta)
    • Etanercept (Enbrel)
    • Fluoxetine (Prozac)
    • Haloperidol
    • Ibuprofen
    • Neomycin
    • Propranolol
    • Ranitidine (Zantac)
    • Sertraline (Zoloft)
    • Venlafaxine
    • Verapamil

    What is Histamine Intolerance?

    Are you Histamine Intolerant?

    • Are you always the one who has to walk away from a family holiday table, or a wine-tasting tour with the BFFs to manage your swelling, sneezing, dizziness or nausea?
    • Do you get headaches after indulging in aged cheese? Heartburn after cured meat?

    You may be histamine intolerant.

    What is Histamine?
    Histamine is one of many biogenic amines – biochemicals produced through the metabolism of amino acids in all living organisms. It's just one of the biochemicals stored in and released by your mast cells – specialized white blood cells.

    When an immune threat, allergen or trauma activates these mast cells, they release inflammatory mediators like histamine. That's when your blood vessels dilate, so that your white blood cells can attack any invader (execute the immune defense response). People who have an overabundance of mast cells in their GI tract may also release access histamine.

    Once formed, histamine is either stored or broken down by an enzyme. The American Society for Clinical Nutrition found that diamine oxidase (DAO) is the main enzyme responsible for breaking down histamine in the digestive tract, so that it doesn't buildup and overflow. When your body doesn't have enough DAO to prevent this overflow you are histamine intolerant.

    What causes High Histamine Levels?
    What is the root cause of such high histamine levels? Sometimes bacterial overgrowth or leaky gut can be the culprit. For people with allergies this intolerance is spurred by an igE reaction. But for the majority of the histamine intolerant, it's a deficiency of the powerful DAO enzyme, without which your digestive system cannot break down the histamines in your diet.

    Histamines and other amines occur naturally in many fruits, vegetables, grains, dairy products and meats. But after they've been aged or fermented, their levels increase, stimulating your immune response, your symptoms – your histamine intolerance.

    Because this is so common, and because most people don't want to give up foods they love, scientists have developed and clinically tested today's top histamine intolerance treatment: Umbrellux DAO.

    This naturally sourced protein supplement replaces the depleted DAO in your small intestine, so you can digest effectively and painlessly. Life's too short to let symptoms control you. Supplement your DAO, resolve your histamine intolerance and get back to the bash!

    Symptoms of Histamine Intolerance
    Because it travels throughout your bloodstream, histamine affects your gut, lungs, skin, brain, and entire cardiovascular system, contributing to a wide range of symptoms which can make a histamine intolerance difficult to diagnose.

    Most people with histamine intolerance struggle with one or more of these symptoms:

    • headaches/migraines
    • nasal congestion, sneezing, difficulty breathing
    • red, watery eyes
    • flushing
    • rash, hives or swelling
    • fatigue or insomnia
    • digestive issues like heartburn and diarrhea

    People with extreme sensitivity may also suffer from:

    • numbness, tingling or peripheral neuropathy
    • hypertension
    • vertigo or dizziness
    • accelerated heart rate (arrhythmia)
    • fluctuating body temperature
    • anxiety
    • nausea & vomiting
    • abdominal cramps
    • abnormal menstrual cycle

    These symptoms strike people with deficient DAO enzyme after they've eaten high histamine foods like: fermented and vinegary foods, certain legumes, certain nuts, certain fruits and vegetables, canned seafood, canned, dried, or salted seafood, aged cheese and aged smoked meats, reheated leftovers, chocolate and certain spices, as well as alcohol.

    But you don't have to go on a strict histamine intolerance diet and give up these tasty, nutritious foods. You can supplement your enzyme levels with Umbrellux DAO.

    This patented DAO enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. Umbrellux DAO is not absorbed and does not have systemic activity – which means it stays in your gut where it belongs.

    Causes of Low DAO Enzyme Levels
    Although there are rare genetic mutations (common in people of Asian-descent) that can cause DAO deficiency, the root of this dysfunction more often lies in the following:

    • gluten intolerance, leaky gut and small intestinal bacterial overgrowth
    • inflammation from Crohn's or ulcerative colitis
    • non-steroidal anti-inflammatory drugs (ibuprofen, aspirin)
    • antidepressants (Cymbalta, Effexor, Prozac, Zoloft)
    • immune modulators (Humira, Enbrel, Plaquenil)
    • anti-arrhythmics (propanolol, metaprolol, Cardizem, Norvasc)
    • antihistamines (Allegra, Zyrtec, Benadryl)
    • histamine blockers (Tagamet, Pepcid, Zantac all deplete DAO levels)
    • DAO-blocking foods (alcohol, energy drinks, as well as black, green and matte teas)

    No matter which of these causes are to blame for your deficiency, supplementing with Umbrellux DAO. can resolve your symptoms.

    How To Test for Histamine Intolerance
    Figuring out whether you are histamine intolerant is not difficult, but it may be time-consuming, as it requires that you pay close attention to your body's reactions, then make adjustments.

    You can usually detect histamine intolerance via:

    • blood testing: a high histamine to DAO ratio signifies that you are ingesting more histamine than your DAO supply can break down; however, blood levels of DAO may not always reflect DAO levels in your GI tract
    • elimination/reintroduction: remove the above high histamine foods for 30 days, then reintroduce them one at a time observing which stimulate symptoms
    • DAO supplementation: rather than follow a strict histamine intolerance diet, add DAO supplementation at each meal – if your symptoms resolve, you likely have low DAO

    The most effective and convenient histamine intolerance treatment is Umbrellux DAO – a porcine sourced enzyme that's gluten, soy and dairy free.


    Take one capsule 15 minutes before meals as needed.


    Diem Labs - Umbrellux DAO Histamine Neutralizing Enzyme 10,000 HDU - 60 Capsules
    Nutrition Facts
    Serving Size 1 Capsule
    Servings Per Container 60
    Amount Per Serving % Daily Value
    Vitamin C (ascorbic acid) 10 mg 17%
    DAO Porcine Kidney Protein Extract 4.20 mg **
    [providing approximately 7% (294 mcg) **
    Diamine Oxidase Enzyme and 10,000 HDU] **
    ** Daily Value (DV) not established.
    Ingredients: Microcrystalline cellulose (plant fiber), hydroxypropylmethylcellulose, sucrose, rice starch, shellac, hydroxypropylcellulose, crospovidone, hydrated magnesium silicate, carboxymethylcellulose and glycerol.

    Does not contain: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.


    Keep closed in a cool, dry place out of reach of children.


    Diem Labs

    Diem Labs is a dietary supplement and medical food company with solutions for underserved and emerging health concerns.

    Quality Standards
    Formed by an international partnership of scientists, nutraceutical ingredient producers, and veterans of the US natural products industry, Diem Direct is driven to supply safe and effective nutraceuticals produced to the highest quality standards and backed by rigorous scientific evidence.


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    The products and the claims made about specific products on or through this site have not been evaluated by or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.
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