Fungi Perfecti Host Defense Reishi Extract - 1 fl oz. (30 mL)
Fungi Perfecti Host Defense Reishi Extract is made with U.S. grown, double extracted organic mushrooms. Host Defense Reishi Extract supports a healthy heart. This popular species, used for more than two millennia in Asia, has been respectfully called the “Mushroom of Immortality.” Reishi grows throughout the world and is found primarily on hardwood trees. This mushroom is well known as a tonic for supporting general wellness and vitality. Liquid extracts provide rapid absorption by the digestive system. Featuring measured droppers for a flexible serving size, Fungi Perfecti Reishi Extract may be used directly from the bottle, or in water, warm tea or juice.
Full Spectrum of Active Constituents
Grown & Processed in the USA
Optimized, Peak Life Cycle Selection
P-Value Certified for Maximum Growth
The Mushroom Renaissance
Mushrooms have been used cross-culturally for centuries as food, clothing, tools and medicinals.
7,000 year-old Tassilli cave paintings
Mushrooms found on 5,300-year-old Neolithic Otzi the Iceman
The ancient writings on mushrooms in the Yellow Emperor’s Classic of Traditional Chinese Herbal, dated 1644
The Genetic Connection
Humans and fungi share more DNA than humans & plants
Plants actually share less than 10% of the same DNA with humans
Fungi and humans share in common infections from the same microbial pathogens. However, fungi, after millennia of evolution, are infinitely more adept at manufacturing compounds to combat these pathogens.
Because of the similarities between fungi and animals, we can digest, assimilate and utilize these fungi as functional foods. Most everyone is familiar with the fruitbody (or mushroom cap), which is the end stage of the fungal life cycle.
The Mycelium holds the crucial life functions of the mushroom organism
The Fruitibody is the reproductive stage
The Spores represent seed-like capsules for complete regeneration
Thousands of Compounds
Compounds found in the fruiting body are just one piece of the full constituent offerings of mushrooms. Novel compounds exclusive to mycelium and the substrate (or food source), are used in combination to create a broader range of available health-promoting constituents.
Functional Food Everyday
Mushrooms have been used throughout history as functional foods. Across the globe they provide macro- & micro-nutrients, while simultaneously conferring benefits to multiple systems in the body.
Optimal Host Defense
Functional food mushrooms support the body’s immune system.
Cultural and traditional use, along with current scientific research, has shown mushrooms have positive correlation with certain functional systems and pathways in the body.
We see this with:
Reishi and the cardiovascular system
Chaga and antioxidant support
Turkey Tail and immune support
Lion’s Mane and brain/nervous system support
Mushrooms Offer Support for a Multitude of Body Systems
Examples include support for:
Multiple Mushroom Species As a Wellness Strategy
Research by Paul Stamets demonstrates that a combination of mushroom species increased immune activity compared to single mushroom species.
In 2003, a study was published in the International Journal of Medicinal Mushrooms, “Potentiation of Cell-Mediated Host Defense Using Fruit Bodies and Mycelium of Medicinal Mushrooms.”
This 7 mushroom blend, Stamets 7, is highly active in immune markers, and can be taken everyday like a multiple.
Currently, there seems to be a lot of confusion about beta-glucans and their contribution to the beneficial properties of mushrooms. In order to shed more light on the subject, Paul Stamets has written a new article, "Beta- Glucan Analysis and the Seven Pillars of Immunity".
Q: Why doesn't Fungi Perfecti list beta-glucan content on their products?
A: Because they want to be accurate. The testing methods used to determine beta-glucan content are highly inaccurate.
Over the years, Fungi Perfecti LLC has spent thousands of dollars on product testing for beta-glucan content at various laboratories. The reported beta-glucan values from several independent laboratories vary greatly even though identical assays were performed. The most commonly employed assays for determination of beta-glucan content can only detect soluble beta-glucans; the insoluble beta- glucans remain undetected. Beta-glucans differ in their solubilities depending on their size, functionality, and interaction with other molecules. In agreement with other organic chemists specializing in beta-glucan analysis, we have concluded that the currently employed methods are unreliable! Deciding to place a percentage on our labels gives us sufficient pause, as we know each methodology and each laboratory would yield a different result. There is no standard, accepted, validated methodology in the industry. This fact makes us reluctant to make any such claims on our product labels, and makes any purported beta glucan levels listed for any mushroom product dubious.
Analytical laboratories have admitted that some mushroom companies use chitinase to convert otherwise water-insoluble sugars (chitin) into beta-glucans so their analyses falsely meet their desired marketing goal; a technique that simply embellishes the beta-glucan content in order to mislead the customer. Another trick some companies employ is to use beta-glucans isolated from yeast, such as Saccharomyces cerevisiae and list them as ‘mushroom beta-glucans’ on their product label—more than a bit of a stretch of logic, truth and reason. Yeasts are the simplest forms of fungi: many yeasts do not form mycelium and lack the cellular complexity of higher fungi, The other, non-beta-glucan constituents embedded into the cellular architecture of mushroom mycelium distinguishes the immunological activity of mushrooms from yeasts..
Here at Fungi Perfecti, we are addressing this problem. Dr. Regan Nally, who directs our chemical analytical division, is leading this research effort by writing for publication an article for peer-reviewed journal exploring numerous inaccuracies in beta-glucan analyses.
So I ask: what would you do? What is the scientifically accurate and ethical response? If you had one identical product tested at several laboratories but whose results ranged from Non Detectable to 40%, which would you put on the label? This is why Fungi Perfecti is different: if we are not confident in the scientific method being used by the industry, we refuse to pass on what we consider to be misinformation.
The immune system is activated multifactorially by many components in mushrooms. Beta-glucans are just one. Other constituents include but are not limited to alpha-glucans, ergothioneines, antioxidants, anti-inflammatory sterols, lipids, glycosides, and mycoflavonoids—many of which work synergistically to optimize health. The efficacy of a multi-constituent approach has been positively confirmed in the scientific literature. Many of these active ingredients are not water soluble, meaning that they are not pulled out by hot water extraction. The inclusion of these beneficial co-ingredients enhances their protective effects. These constellations of complementary constituents are the foundation of our Host Defense mushroom product line.
Seven Pillars of Immune Benefits From Mushrooms
Seven primary constituent classes, or “pillars” buttress the immunity enhancing effects of mushrooms.
Polysaccharides (ex. Alpha & Beta-glucans): Immunomodulating
Glycoproteins (ex. PSK): Immunomodulating
Triterpenes (Sterols, ex. sistosterols, stigmasterols, campesterols)
Lipids: Cholesterol modulating
Proteins (Enzymes): Antioxidants
Cyathane Derivatives (ex. erinacines & hericenones, nerve growth stimulant factors)
Mushrooms have approximately 12,000 genes controlling the production of more than 200,000 compounds. Each mushroom species has a unique genetic identity and molecular architecture. This is what defines a species. After thousands of years of experimentation by our ancestors, we now know which are some of the most beneficial of the tens of thousands of mushrooms in existence. From this set, we have selected the best-documented, scientifically-studied and safest functional mushrooms in nature that can be cultivated. We have successfully developed methodologies to sustainably cultivate these species.
We can now benefit from the natural host defenses of not just mushrooms, but also their precursor living mycelium, an opportunity that was not accessible to the ancients. Embedded within this highly integrated molecular matrix of fungal cells are beneficial active ingredients. Our bodies are able to utilize these active ingredients, provided the mycomaterial is pure, genetically potent and bioavailable.
Much has been written about extraction methods for isolating single classes of constituents. Extraction necessarily excludes other derivatives. Hot water, for example, has been used for centuries in teas and soups. Hot water isolates soluble sugars, including certain beta-glucans, glycoproteins and triterpenoids. Alcohol extraction, also proven effective for more than two millennia, on the other hand, can solubize many sterols, ergothioneines, glycosides and flavonoids. Ethyl acetate is yet another solvent often used. Each solvent fractionates out only a few of the Seven Pillars of Immunity from Mushrooms.
By combining water and alcohol extraction methods, and retaining the insoluble matter that precipitates, we benefit from capturing all Seven Pillars. By consuming properly prepared mushroom products, the acids and enzymes of our digestive system carry out the extractions for us, selecting what it needs most from the panoply of constituents. A less comprehensive method of extraction employs a singular solvent, excluding the many benefits of the solvent-insoluble active ingredients. Knowing mushrooms offer a wide range of beneficial compounds, which work together, but whose solubilities greatly differ, choosing one solvent over another becomes difficult.
Simply put, what benefits do you not want?
The classic model of how beta-glucans work is that they are recognized by the immune system as an invasive organism, activating the body’s immune defenses as if to fight an infection. The mushroom mycelium’s ability to defend itself from infectious diseases by staving off invasive organisms can offer us shields of protection not only through direct anti-microbial activity but also from the production of our host-mediated immune cells. Other extracellular compounds, such as antioxidants, have more indirect influences. Antioxidants protect DNA from oxidative stress damage and detoxify the body of free radicals. Mushrooms also modulate the inflammatory response from causing collateral oxidative damage to surrounding healthy tissue. This makes them especially useful as adjunct therapies to conventional medicine. Knowing the particular attributes of each mushroom species provides us with the ability to develop targeted approaches to many categories of disease.
In the view of the FDA, the isolation, concentration, and purification targeting a single active ingredient from mushrooms can designate them as pharmaceuticals. Using the mushrooms and mycelium in their natural forms make them functional foods. With mushrooms, the adage that “the whole is greater than the sum of its parts” seems particularly descriptive. For the majority of us, mushrooms are a whole system tonic, benefitting overall human health, fortifying and readying your host defense of immunity.
Fungi Perfecti and founder Paul Stamets-mycologist and author of six books on mushroom cultivation and identification, including the definitive text Growing Gourmet & Medicinal Mushrooms-are proud to offer their customers the finest mushroom supplements available today:
- Direct from the source, 100% grown and processed in the USA
- Certified Organic by the Washington State Department of Agriculture
- Free of GMOs, pesticides and other contaminants
- Sustainably cultivated under strictly controlled laboratory conditions
- Backed by the Stamets P Value System
Each mushroom species collected by Paul from the old growth forests of the Pacific Northwest is sustainably harvested by taking a small sample of tissue with which to generate a master culture. The ecosystem and its mushrooms remain intact and unharmed. Fungi Perfecti then carefully cultures this mycelium for the Host Defense products under strictly controlled laboratory conditions at their facility in Washington State, supervised by Paul Stamets and his skilled staff. Fungi Perfecti has a verifiable chain-of-custody that is critical for traceability (many companies do not).
By buying from Fungi Perfecti you can be assured that you are getting a bona- fide product of the highest quality. A portion of the proceeds from your purchase goes to Fungi Perfecti's research to save rare strains of mushrooms that dwell within the old growth forests.