0.1000Circulation SupportUSD
Doctor's Best - Best Hesperidin Methyl Chalcone 500 mg. - 60 Vegetarian Capsules
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Doctor's Best - Best Hesperidin Methyl Chalcone 500 mg. - 60 Vegetarian Capsules

Supports Veins & Capillaries
Item #: 126410
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Doctor's Best - Best Hesperidin Methyl Chalcone 500 mg. - 60 Vegetarian Capsules

  • Item# :126410
    UPC# :753950002876
  • Brand:Doctor's Best
  • Size/Form:60  Vegetarian Capsules
  • Ship Weight:0.10
  • Servings:60
  • Dosage:1  Capsule(s)

Doctor's Best Hesperidin Methyl Chalcone 500 mg - 60 Vegetarian Capsules

Doctor's Best Hesperidin Methyl Chalcone, sourced from Spain, is a flavonoid derived from citrus fruits that many experts believe has synergistic activity with vitamin C. Doctor's Best Hesperidin Methyl Chalcone may also increase vein and capillary strength. While hesperidin in its original form is not very water soluble, hesperidin methyl chalcone (HMC) is highly water soluble for greater absorption in the gastrointestinal tract. Like all flavonoids, HMC is an antioxidant. Doctor's Best Hesperidin also supports eye health and has blood vessel-stabilizing effects.

  • Science-based nutrition
  • Dietary supplement
  • Helps protect heart and blood vessels from oxidation
  • Supports vascular integrity and helps improve capillary strength

Best Hesperidin Methyl Chalcone, obtained from a quality source in Spain, is a methylated derivative of the bioflavonoid hesperidin. Hesperidin occurs in citrus fruits, particularly sweet oranges, tangerines, and lemons, often in association with vitamin C. It was first discovered in 1827, but gained more attention in 1936 when the famed researcher Albert Szent-Gyorgyi reported that bioflavonoids contributed to lessening the circulatory problems associated with scurvy, a condition that results from vitamin C deficiency.
After scientific investigations revealed that a crude extract of vitamin C was able to relieve symptoms that purified vitamin C could not, bioflavonoids in citrus were found to work synergistically with vitamin C. Among these citrus bioflavonoids, hesperidin is prominent in helping vitamin C to improve capillary strength, to such an extent that for many years it was termed “vitamin P.” In 1947, the methyl chalcone form was found to be more bioactive than native hesperidin and to work synergistically with vitamin C.

Antioxidant Support for Circulatory Health
Hesperidin is a powerful neutralizer of free radicals. In cell culture experiments, hesperidin provided strong protection against agents that could cause cell damage via the production of superoxide and hydroxyl free radicals from oxygen. The potent antioxidant activity of hesperidin, and/or metabolic products derived from it, is one likely basis for its structural support of the capillaries and other small blood vessels.

Supports Vascular Integrity and Capillary Strength
Reports dating from the 1930s indicate that hesperidin supports blood capillaries by increasing capillary wall tone. Hesperidin methyl chalcone in combination with vitamin C was shown to regulate hyaluronidase (an enzyme that breaks down hyaluronic acid), thereby helping to support the integrity of capillary walls.
Maintenance of the blood vessel endothelium (the one cell thick layer that lines the blood vessel on the inside) is critical for the health of the circulatory system. Among the many functions of these endothelial cells is to control blood vessel tone and help regulate blood flow to organs. In a randomized, double-blind, placebo-controlled trial of 28 individuals with Metabolic Syndrome (this syndrome is not a disease, but rather a cluster of health factors important to watch), participants were given either 500 mg hesperidin or placebo capsules containing cellulose every day for 3 weeks. Endothelial function was assessed by measuring flow-mediated dilation (FMD) in the brachial artery. Compared to placebo, participants taking hesperidin had significantly superior FMD after 3 weeks of supplementation.
Additionally, these researchers reported results from a cell culture study they performed to investigate potential mechanisms that might explain the results seen in the clinical trial. Treatment of the cells with hesperidin caused enzymes such as nitric oxide synthase to produce nitric oxide, a key molecular messenger for maintenance of healthy vascular function. This experiment is particularly instructive because the effective concentration of hesperidin on these cells can likely be achieved in the body by consuming a 500 mg daily dose of hesperidin.
Hesperidin also produced circulatory benefits in a clinical trial with 24 healthy, middle-aged, moderately overweight men. This randomized, placebo-controlled trial monitored the capacity of the blood vessel endothelium to manage relaxation of the vessel wall. Blood pressure was recorded at the beginning and end of each 4-week period. Hesperidin significantly helped participants maintain healthy blood pressure levels in the normal range.
In an extension of this clinical study, the researchers sought evidence that hesperidin may act at the level of the genes. Ten of the original 24 male subjects donated white blood cells that were studied for changes in gene activity due to hesperidin. A total 1,819 genes were found to be regulated by hesperidin, and the pattern of the changes in gene expression—such as in the areas of cell communications, immune response, and lipid metabolism—could be considered as supporting healthy blood vessels. This study was groundbreaking in that it links hesperidin intake to favorable effects on gene functions.
In another area of circulatory health, an animal model suggests that hesperidin may support healthy eyes by promoting ocular blood flow (delivering nutrients and oxygen to the eyes). Hesperidin was shown to increase blood flow to the iris, ciliary body, and choroid parts of the eye in rabbits.
Hesperidin also offers the potential to support brain health. Experimental cell research demonstrated that hesperidin protected nerve cells against oxidative damage. The relatively low concentration of hesperidin used in this study can likely be attained in the body by taking hesperidin supplements. Other studies have suggested that hesperidin can cross the blood-brain barrier, an important requirement for bioactive compounds to potentially support brain cells.

Best Hesperidin Methyl Chalcone from Doctor’s Best offers a powerful citrus flavonoid in a highly absorbable form, with a long history of research that suggests diverse benefits for circulatory health.

Quality Standards
Doctor's Best produces products with the highest quality raw materials available on the market. How? They have direct control over and are an integral part of every aspect of product production, from formulation and raw material sourcing to finished product manufacturing. They directly purchase all active ingredients used in their products and use only the highest quality ingredients.

Science Based Formulations
Every product is thoroughly researched and backed by the latest scientific studies conducted in the field. Their formulations reflect the amounts of ingredients shown to be beneficial based on the results of scientific investigations. They use patented, trademarked ingredients backed by scientific studies and clinical research. We never use insignificant quantities to enhance the label.

Raw Materials
Doctor's Best directly purchases only the highest grade raw materials from proven and reputable suppliers to be put into product formulations. All raw material suppliers go through our stringent vendor qualification process, which includes a multi-step investigation including all aspects of the production and handling procedures, to insure the highest level of quality is reached.

Finished Product
Whether producing a product with one raw material component or many, each finished product is held to the highest cGMP standards and produced under rigid quality control points to ensure product safety, potency, and uniformity. Their rigorous quality assurance and control processes ensure our customers receive only the highest quality nutritional products that exceed industry standards and provide exceptional nutrition benefits.

Quality Promise
Doctor's Best never compromises on ingredients, quality, or science. As a privately owned, independent entity, their answer only to our customers and the retailers who carry our products. They all depend on the integrity of the people and products with whom they deal. Since the day they went into business more than 17 years ago, Doctor's Best has pledged itself to that policy. The bottom line is, if Doctor's Best offers it, it's a proven nutritional concept with genuine health benefits.

About Doctors Best
Doctor's Best firmly believes in the integration of science research and traditional wisdom as the way that nutritional and herbal supplements will reach their exciting potential.

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor's Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation.

Containing the finest quality raw materials from around the world, Doctor's Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace.

Each of their products is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

Traditional wisdom ... up-to-date research ... product quality you can trust ... all the information you need to develop smart strategies for achieving optimal health and well-being.

Take 1 capsule once or twice daily with food, or as directed by a nutritionally informed physician.

Doctor's Best - Best Hesperidin Methyl Chalcone 500 mg - 60 Vegetarian Capsules
Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 60
Amount Per Serving %DV
Hesperidin Methyl Chalcone 500 mg *
*Daily Value Not Established.
Other Ingredients: Modified cellulose (vegetarian capsule), cellulose, magnesium stearate (vegetable source).
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About Doctor's Best

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

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By (Puyallup , WA )

This product was suggested to me to use for reducing hot flashes. Amazing results. They have not gone away completely, but what a difference. I take a medication that kills my estrogen because of breast cancer. Now I can sleep at night with only a few hot flashes that wake me.

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