Douglas Laboratories Metabolic Lean - 60 Vegetarian Capsules
Douglas Labs Metabolic Lean is a novel weight management formula that includes three branded and clinically studied ingredients-- Meratrim plant extract, Capsimax capsicum extract, and Zychrome Chromium complex. Douglas Labs Metabolic Lean special combination of ingredients may improve lipolysis, thermogenic activity, and insulin function. The ingredients in Douglas Labs Metabolic Lean also help to increase adiponectin levels which facilitateproper fat metabolism and glucose regulation. Douglas Labs Metabolic Lean is indicated as a dietary supplement for individuals desiring weight management support.
Meratrim is a proprietary plant extract blend for weight management derived from two plants, Sphaeranthus indicus and Garcinia mangostana, traditionally used in Southeast Asian culture. Meratrim has been shown in two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body weight, BMI, and waist circumference within 8 weeks when used in combination with a diet and exercise plan. Meratrim appears to achieve this by modulating the accumulation of fat while simultaneously increasing fat burning. Toxicological studies on Meratrim have demonstrated a wide margin of safety.In vitro studies demonstrate that Meratrim modulates the expression of biomarkers that control adipogenesis and lipogenesis as follows:
- Reduces the expression of the peroxisome proliferator-activated receptor gamma (PPAR) hormone receptor. PPAR induces adipocyte-specific genes involved in the formation and growth of fat cells.
- Reduces the expression of adipocyte differentiation related protein (ADRP). This is a signaling protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte differentiation.
- Reduces the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that facilitates fatty acid uptake by adipocytes.
- Reduces perilipin expression. Perilipins are adipocyte proteins that are localized at the surface of the lipid droplet and inhibit fat break down by restricting access of lipase to the lipid droplet.
Capsimax capsicum extract is a proprietary encapsulated form of premium, highly concentrated natural capsicum fruit extract manufactured from hot red peppers. Capsaicinoids are a group of compounds which cause the “heat” found in hot peppers. In fact, over the past 30 years, studies including animal and human subjects support the potential of red hot capsicum and capsaicinoids as a safe, effective ingredient to aid inweight management. Benefits of capsicum and capsaicinoids in animal and human studies have shown that it helps manage appetite, supports healthy metabolism to burn calories, and helps induce thermogenesis. Capsimax is a patent-pending encapsulated form of premium, highly concentrated natural capsicum extract. Using a proprietary matrix, Capsimax capsicum extract gives users the maximum effectiveness of capsaicinoids without any oral or gastric irritation, thus solving the problem of capsicum compliance.
Zychrome is a unique, patent-pending chromium complex consisting of chromium, niacin and L-cysteine (chromium dinicocysteinate). Seventeen chromium complexes were screened in preclinical studies in order to arrive at the complex found in Zychrome. In vitro and in vivo studies demonstrated that Zychrome is more efficacious than other forms of chromium in supporting healthy fasting glucose levels, glycated hemoglobin levels (HbA1c), insulin levels, CRP, MCP-1, ICAM-1 and oxidative stress levels†. These effects of Zychrome are mediated by the regulation of cell signal transduction pathways associated with insulin function, glucose control and vascular inflammation. A randomized, double-blind, placebo-controlled clinical study showed that Zychrome significantly modulated the levels of insulin and insulin resistance as well as the inflammatory cytokine TNF and protein carbonyl content, a marker of oxidative stress. Toxicological studies have demonstrated a wide margin of safety.
Trust Douglas Laboratories, The Choice Of Thousands Of Healthcare Practitioners For Over 50 Years.
Trust Douglas Laboratories for a partnership founded on a heritage of excellence. For more than 50 years, they have been at the forefront of the nutritional health industry, proudly researching, developing and manufacturing superior-quality, science-based dietary supplements to help people improve their health. Proudly earning the trust of thousands of healthcare professionals.
Trust Douglas Laboratories for best-in-class, science-based dietary supplements manufactured exclusively for healthcare professionals. We are proud to offer one of the largest and most innovative selections of over 600 premium-quality products and a comprehensive range of galenic forms (dosage and delivery), manufactured at GMP- compliant, state-of-the-art facilities.
Trust Douglas Laboratories for personalized, one-to-one consultation on the latest, most reliable science, for strategies on using nutritional health to complement your practice and for coaching to better advise your patients on the right supplements for them.
About Douglas Laboratories
Back in 1955, Sam Lioon, founded Douglas Laboratories on a simple promise: provide the highest quality nutritional supplements available with the highest level of personal service—anywhere. And with that promise began a legacy of leadership—and a never-ending quest to exceed their customers’ expectations to Raise the Standard for Nutrition and Wellness.
Today that legacy lives on as Douglas Laboratories proudly joins the Atrium Innovations group of companies. Atrium Innovations is an international company and global leader in the development, manufacturing, and marketing of dietary supplements, specialty fine chemicals, and active cosmetic ingredients.
Douglas Laboratories is supported by more than 300 Douglas Laboratories employees all dedicated to keeping the promise Sam made 50 years ago. Raising the Standard is more than a slogan—it’s a promise. As they enter their second half-century, Douglas Laboratories will continue to keep their promise to Raise the Standard with a custom approach to ytheir patients’ nutrition and wellness. With custom formulations ytheir patients can’t find anywhere else. Custom labels. Custom daily packs. And the industry’s largest and most innovative product line. And they’ll back up their promise with the kind of stringent criteria many other companies overlook, such as:
- (cGMPs) current good manufacturing practices.
- ISO 9001 Certification and ISO 17025 Accreditation of their laboratories.
- The industry’s first fully electronic, bar code driven, paperless manufacturing system to pass the FDA’s rigorous audit. Their exclusive
- Veri-Match labeling system, ensures verification prior to production and release of ytheir products.
- (SOPs) standard operating procedures.
- VCP (Vendor Certification Program) ensures raw material safety and quality.
- Experienced, on-staff Ph.D’s, utilizing three full-service laboratories, outfitted with the latest analytical equipment.
- State-of-the-art manufacturing, including ultra high-speed encapsulating machines, capable of producing over 35 million capsules and tablets daily!
- Full compliance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002, assuring safety and uninterrupted flow of all raw materials.
Douglas Laboratories continues to lead the way with clinical trials designed to validate the efficacy of their products. Their world-renowned Ultra-Preventive X (Ten) was rated the #1 multivitamin in the professional healthcare market, and their Vita-Big-Kids was rated the #1 children’s multivitamin overall by the independent Comparative Guide to Nutritional Supplements. Their commitment to help support patient outcomes is ongoing; look for their new in-office patient education posters, easy online ordering from their website and more innovative ideas designed to help ytheir practice grow in the days ahead.
But most of all, they’re proud of the many long-standing relationships they’ve enjoyed with so many customers over the years, and the many great friendships they’ve made along the way. It’s not an exaggeration to say that they truly enjoy what they do, enjoy coming to work each and every day.