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DROPPED: Biotics Research - Histoplex - 90 Capsules CLEARANCE PRICED
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Biotics Research - Histoplex - 90 Capsules

Item #: 107471
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Biotics Research - Histoplex - 90 Capsules

  • Item# :107471
    UPC# :055146063400
  • Brand:Biotics Research
  • Size/Form:90  Capsules
  • Ship Weight:0.10
  • Servings:45
  • Dosage:2  Capsule(s)

Biotics Research Histoplex - 90 Capsules

Biotics Research Histoplex supplies a proprietary blend of herbal extracts shown to possess immunomodulating properties.  The immune system normally discriminates between “self” and “non-self” foreign substances.  Thus, it represents an elaborate, finely tuned defense system to destroy microorganisms,cancer cells,or other invasive materials.  However, an imbalanced immune system can attack the body's own tissues (auto-immune conditions) and lead to cumulative oxidative stress.

The immune system consists of two branches, cellular immunity and humoral immunity.  The first depends upon the active participation of multiple cell types, including a variety of phagocytic cells,to engulf invaders.  Lymphocytes include highly specialized Tcells, which proliferate and differentiate in the thymus gland.  In a typical scenario, macrophages process ingested antigens and display recognition fragments on their surfaces.  T helper cells acting as generals, read these antigens and in turn stimulate the production of T killer cells via lymphokines such as IL-2andgammainterferon.  Mast cells are a type of T cell embedded in tissues to fight localized infection. When they contact foreign materials, mast cells destroy them. In the process, they release histamine and other agents that cause edema, increase blood vessel permeability and recruit neutrophils to the site of inflammation.

Humoral immunity pertains to proteins of the blood and lymph. This aspect of the immune system relies on B cells which mature to plasma cells that secrete specific antibodies and complement proteins to fight infections.  Complement also triggers localized inflammation.  T helper cells regulate the production and maturation of B cells through lymphokines. T suppressor cells gear down the immune response and thus are critical in allergy attacks and auto immune conditions. 

Immunity is a hallmark of the immune system.  Recovery from an invader renders the individual immune to a subsequent attack. The underlying mechanism involves memory T cells and memory B cells. These memory cells multiply rapidly when they reencounter the stimulating antigen.

An allergic response involves both cellular and humoral mechanisms. In contrast, other types of sensitivities to foods, such as  lactose intolerance or sulfite sensitivity, do not  employ  the  immune system.  Allergic responses can be generally classified as immediate or delayed hypersensitivities.  Immediate hypersensitivity represents a rapid over-reaction of the immune system, often within minutes after exposure to the problem antigen.  Particularly mast cells release histamine, leukotrienes and other stimuli that evoke swelling, hives, itchiness, copious mucus secretion and muscle spasm of the GI tract and bronchioles. The reaction is mediated by IgE antibodies. Anaphylactic shock results from an immediate hypersensitive allergic reaction affecting the whole body.  Depending on how  food allergy is defined, estimates of the prevalence range from 2% to 25% of the US population.  Immediate allergic reactions account for only a small fraction of food allergies. Typical food allergies frequently involve IgG antibodies, and symptoms develop within hours or days after contact with a problematic food. Faulty digestion and increased gut permeability are often a root cause of multiple food allergies, because food allergens that are normally excluded, cross the intestinal barrier and enter the blood stream.  The resulting immune complexes, if not cleared rapidly, can lodge in various organs and tissues where they can trigger inflammatory conditios. Food allergies have been linked to a range of auto  immune conditions, rheumatoid arthritis, for example.

Detecting food allergies can be perplexing.  The delay between ingesting a specific food and the development of sometimes vague symptoms often masks food allergy reactions. The most frequent symptom is fatigue. Other symptoms include delayed hypersensitivity,  irritability, achy joints, bloodsugar dysregulation, PMS- l ike symptoms, puffy eyes with dark circles and postnasal drip. Food allergies can cause asthma when they affect the respiratory tract; headache and insomnia when they affect the nervous system; and indigestion, irritablecolon, constipation or diarrhea when they affect the GI tract.  A variety of laboratory tests to detect IgE and IgG subclasses responsive to particular antigens have been developed.  These have varying degrees of reliability.

Botanical Support of the Immune System
A variety of  botanical  preparations have been reported as useful nutritional adjuncts for protocols designed  to help normalize immune processes:

Juglans nigra. Originating in Asia, Juglans nigra has a history of use in Greek and Roman traditions.  It is said to be bitter, pungent, warm with cooling potential and is used with intestinal Qi stagnation.  Black walnut leaf supports the immune system and normal tissue repair processes.

Olea europaea. Buds and leaves of olive trees contain oleuropein, a phenolic glycoside, and rutin, luteolin and hesperidin - flavonoid glycosides.  The latter flavonoids possess well-defined antioxidant properties and affect aspects of the vascular system as well as the immune system. Oleuropein is the  bitter principle of green olives. It can effectively prevent the oxidation of LDL in vitro Antimicrobial properties of oleuropein. have been reported, perhaps explaining the resistance of olive tree to microbial overgrowth.

Hydrangea arborescens. Contains thunberginols and hydrangenols which have been extensively studied by Japanese investigators. This family of compounds was shown to inhibit the release of histamine from rat mast cells and histamine-induced contraction of isolated guinea pig trachea.

Thunberginol A administered  to rats and mice normalized various aspects of immune function.

Hesperidin.  The  rut inoside of  hesperitin.  Hesperidin is the predominant flavonoid in lemons and sweet oranges. In orange, lemon, and grapefruit skins, hesperidin and hesper i t in are mainly  responsible for the antioxidant activity of methanolic extracts.  It seems also to have a membrane-stabilizing effect.  Effects in supporting the immune system have been reported.

Andrographis paniculata (Kalmegh). Folk traditions in India use this herb to support functions of the gastrointestinal tract, reduce flatulence, improve appetite and normalize liver function. Pretreatment of rats with extracts of this plant prevented carbon tetrachloride induced liver damage. Leaf extracts and isolated and rographolide inhibited lipid peroxidation due to exposure to carbon tetrachloride.

Coriolus versicolor. Polysaccharide extracts of this mushroom are composed mainly of beta glucan, together with some protein. This material  has been in use in Japan, where it has been reported to enhance normal functioning of the immune system.  For example, it  improved T cell response in gut associated lymphoid tissue in mice.  In rats, this extract increased B cells.  The production of T cells increase dinspleenand Peyer’s patches, but not thymus.  These mushroom polysaccharide extracts are associated with super oxide dismutase activity.

Picrorrhizakurroa. Roots and rhizomes contain a mixture of flavonoids, including glycosides, piroside and kutkoside, picrorhizin, and the phenolic ether, apocynin.Apocynin was shown to inhibit the neutrophil oxidative burst in vitro.  Apocynin inhibited the formation of thromboxane A,while stimulating there lease of prostaglandins by isolated guinea pig pulmonary macrophages.  Picrorrhiza abstracts were found to support normal of T and B cell function using rodent model systems.

Ligsuticum porteri. The Ligsuticum family contains a number of compounds with  aromatic character.  Osha has  long beenused in folk traditions in South western United States and  Northern and Central Mexico.

Quality Control - What Sets Biotics Apart

The Biotics Research way!

At Biotics Research Corporation, we manufacture our own branded products on site, in our own state of the art facilities, allowing for complete control of the entire manufacturing process. In our on-site laboratories, the highly skilled members of our Quality Control Unit, utilize modern, sophisticated technologies and validated analytical methods to test incoming raw materials, monitor manufacturing processes, perform in-process testing, and test all finished products prior to their release for shipment. In fact, many aspects of our cGMPs (current Good Manufacturing Practices) exceed the new, recently enacted FDA guidelines for dietary supplements in order to ensure the safety and effectiveness of our products.
The Quality Control Unit (QCU) has the authority to approve and/or reject all specifications and procedures associated with the production and release of all raw materials, packaging materials and finished products, including test methods and results, instrument calibrations, and processing records. The QCU conducts all internal audits, and validates and audits all raw material and packaging suppliers and service vendors as well.

All incoming raw materials are subject to appropriate testing prior to their release for production. Tests conducted include identity, potency, biological activity, microbiological, including bacteria, yeast and mold (including aflatoxins) and heavy metals (arsenic, cadmium, lead & mercury). Retained samples are maintained of all raw materials and finished products for future testing requirements (raw material stability and finished product expiration date verification).

All bulk finished products (tablets & capsules) are inspected and subjected to metal detection prior to being sampled by QC. They are then subject to appropriate disintegration and/or dissolution testing, and potency testing prior to being released to packaging. All liquid and powder products are tested for potency prior to packaging as well. Finally, microbiological testing is performed on all finished products and document reconciliation is completed prior to being released for shipment.

All testing is performed by our trained QC personnel using state of the art laboratory instrumentation including High Pressure Liquid Chromatography (HPLC), ICP, Atomic Absorption Spectrophotometry (AA), gel electrophoresis, FT-IR, Ultra Violet spectrophotometry, Thin Layer chromatography and Gas Chromatography-Mass Spectrometry (GC-MS).

Unlike many companies that are struggling to meet the new GMP requirements established by the FDA, companies that are being regulated into implementing quality programs, extensive Quality Control has always been part of the corporate fabric of Biotics Research Corporation.

From day one, the mantra of Biotics Research Corporationhas been "Innovation and Quality." Our goals remain unchanged - utilize innovative ideas and carefully researched concepts with advanced techniques to develop products of superior quality and effectiveness - bringing you "The Best of Science and Nature".

Two (2) to three (3) capsules two (2) times each day as a dietary supplement or as otherwise recommended by a healthcare professional.

Biotics Research - Histoplex - 90 Capsules
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 45
Amount Per Serving %DV*
Proprietary Blend 1.2g
Osha (ligusticum porteri)(root) *
Hesperidin (citrus fruit extract) *
Dimethylglycine *
Olive (olea europaea)(leaf) *
Hydrangea (Hydrangea arborescens)(root) *
Black Walnut (Juglans nigra)(leaf) *
Andrographis (Andrographis paniculata)(extract)(aerial part) *
Picorhiza (picrorhiza kurroa)(extract)(root) *
Calcium borogluconate *
Turkey Tails (Trametes versicolor)(whole) *
*Daily Value Not Established.
†Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
Other Ingredients: Capsule shell (gelatin and water).

Not recommended for pregnant or lactating women.  Keep out of reach of children.

6801 BioticsResearch Dr.
Rosenberg, TX,
Phone: 800-231-5777 Fax: 281-344-0725 Visit website

About Biotics Research

Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

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*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.