Biotics Research BioProtect - 90 Capsules
Biotics Research BioProtect supplies a wide spectrum of anti-oxidant nutrients in reasonable amounts to assist in the bodies ability to "quench" free radicals, compounds that cause biological damage to cells.
For the Health of Your Patients:
As a broad spectrum antioxidant, BioProtect provides support against free radical damage. Free radicals are atoms or molecules containing an unpaired electron, which seeks to reign in other electrons in order to achieve a more stable, less reactive configuration. Free radicals cause biological damage, generally by oxidative processes, and may be expressed directly as damage to cellular components, or indirectly by a disturbance in the redox state of the cell that maintains the metabolic central processes. Through direct damage, free radicals may damage vital components of the cell, including DNA and proteins. For example, free radicals may damage the lens proteins in the eye, leading to age-related degeneration. Free radicals can oxidize LDL cholesterol; oxidized free radicals have been implicated in events that cause damage to arteries. When the body’s natural defenses are overwhelmed, free radicals indiscriminately attack neighboring molecules. Many chronic conditions have been associated with damage from free radicals, ensuing as a result of an imbalance between radical-generating and radical-scavenging systems. This type of situation is deemed “oxidative stress”.
For the Health of Your Practice:
BioProtect provides a balanced array of potent antioxidants and synergists, ranging from vitamins and minerals to phytochemicals and powerful antioxidant enzymes, specially formulated for enhanced bioavailability and effectiveness. Antioxidants have the ability to “scavenge” free radicals and inhibit their chain reactions. The multitude of antioxidants included in BioProtect play various roles and act in synergy to support the body’s natural defense mechanisms. For example, natural carotenoids are able to quench singlet oxygen, thereby inhibiting free radical chain reactions. Superoxide dismutase (SOD) and catalase are supplied via our specially grown, biologically active vegetable culture. SOD is our primary enzymatic free radical scavenger, and is the only enzyme specifically designed to disarm free radicals in the body. Additional antioxidants and synergists supplied in Bio-Protect include: vitamins A, C, and E, zinc, selenium, CoQ10, Glutathione, N-acetylcysteine, L-methionine, potassium sorbate, and taurine. BioProtect is available exclusively by Biotics Research Corporation and is another fine example of Biotics Research bringing you “The Best of Science and Nature”.
What is a Free Radical?
A free radical is an atom or molecule containing an unpaired electron, which seeks another electron in order to achieve a more stable, less reactive configuration. Free radicals cause biological damage, generally by oxidative processes. Free radicals include superoxide, nitric oxide, hydroxyl radicals and fatty acid peroxyl radicals. The harmful effects of free radicals may be expressed directly as damage to cell components, or indirectly by a disturbance in the redox state of the cell that maintains the metabolic central processes.
The Oxygen Paradox
The foundation of energy metabolism is based on efficient oxidation of carbohydrate and fat by mitochondria which depends upon oxygen. Paradoxically, oxygen also creates damaging molecules in the body called reactive oxygen species (ROS). Thus, oxidative stress can be considered a condition experienced by cells in the presence of oxygen. Damaging oxidizing agents include ROS, such as hydrogen peroxide, lipid peroxides, and free radicals. Tissues can be damaged by ROS when the body’s defenses are overwhelmed. Free radicals indiscriminately attack neighboring molecules to make up for their own deficiency and they initiate chain reactions. Free radicals and ROS may damage vital components of cells, including DNA and proteins, for example, the lens proteins of the eye. Free radicals can oxidize LDLs; oxidized LDLs are implicated in events that can cause damage to arteries.
What Can Cause ROS and Free Radicals (in vivo)
Energy Production: The body’s metabolism requires an oxygen-rich environment. Mitochondrial ATP production depends upon molecular oxygen to completely oxidize fat and carbohydrate. Impaired mitochondria can “leak” superoxide, which can further damage mitochondrial energy producing systems.
Detoxification: The liver, intestine and kidney modify potentially damaging compounds using oxidative enzymes classified as cytochrome P450 oxidases. These enzymes use molecular oxygen inefficiently, yielding superoxide.
Chronic Inflammation: Inflammation can lead to tissue damage. During inflammation, free radicals and ROS are produced in amounts that can eventually overwhelm cellular defense mechanisms.
Diet: The typical U.S. diet is low in fruits, vegetables and associated phytochemicals believed to minimize free radical damage.
Leaky Gut Syndrome: “Leaky gut syndrome” characterized by increased intestinal permeability, can increase the uptake of potentially damaging substances.
Aging: Aging diminishes the abiity to respond adequately to oxidative stress.
BioProtect’s Multiple Antioxidant Nutrients
Mixed, Natural Carotenoids. Typical fruits and vegetables supply alpha carotene, beta carotene, lutein, zeaxanthin, and lycopene.
Beta Carotene,The major precursor of vitamin A, is a powerful lipid-soluble antioxidant able to quench singlet oxygen and to inhibit free radical chain reactions. Beta carotene is aided by other carotenoids to block free radicals and to boost the immune system. Recent studies indicate that natural mixed carotenoids (including isomers of beta carotene) are better absorbed and function as more effective antioxidants than synthetic (all trans) beta carotene. Lycopene is a member of the carotenoid family which imparts a healthy red color to fruits and vegetables. Lycopene is not found in the natural mixed carotenoids found in the sea algae Dunaliella salina. BioProtect blends the lycopene produced from specially bred and cultivated tomatoes with the natural mixed carotenoids isolated from Dunaliella salina. Unlike the synthetic beta carotene or mixed carotenoids found in other products, BioProtect provides a full spectrum blend of the natural carotenoids, beta carotene, alpha carotene, lycopene, zeaxanthin, crytoxanthin, and lutein. Biotics Research Corporation was the first supplement manufacturer to incorporate natural, mixed carotenoids throughout its product line.
Vitamin E, Emulsified. Vitamin E functions as the body’s major lipid-soluble antioxidant. It quenches free radicals and singlet oxygen, and it protects membrane lipids against free radical attack, and it reduces LDL oxidation in vitro. Vitamin E blocks the formation of nitrosamines and also enhances the immune system, including activation of phagocytic activity of white cells in elderly patients.
Vitamin C. Vitamin C (ascorbic acid) is a versatile water soluble antioxidant found in blood and tissues. Several organs and cell types, including adrenal glands and lymphoytes, accumulate high levels of vitamin C. Elevated serum vitamin C is associated with enhanced immune function, reduced heavy metal toxicity and increased liver clearance of toxins. Ingested vitamin C can inhibit the formation of nitrosamines and fecal mutagens. As an example of the synergistic effects of antioxidants, vitamin C can recycle vitamin E. Recent saturation studies indicate that the RDA for vitamin C should be increased to at least 200 mg for healthy young adults.
Sulfur Amino Acids. Methionine functions primarily as the source of the thiol amino acid, cysteine, which helps maintain proteins in a reduced state. Methionine can complex heavy metals via cysteine, and as a methyl donor, methionine assists detoxication reactions. N-acetyl-l-cysteine is a stable derivative of cysteine absorbed rapidly deacetylated to yield free cysteine in cells where it increases glutathione levels and enhances detoxification reactions.
Reduced Glutathione (GSH). GSH quenches free radicals and helps regulate the redox balance of cells. The important defensive enzyme glutathione peroxidase employs GSH to reduce lipid peroxides and hydrogen peroxide. Glutathione transferase detoxifies potentially damaging chemicals as part of the phase 2 liver detoxification system. Consequently, toxic exposure can deplete the liver of GSH. Orally administered GSH can raise serum glutathione levels.
Taurine. This derivative of cysteine contains oxidized sulfur and does not occur in proteins. It occurs in high levels of heart muscle emphasizing its role in modulating calcium flux and neuron excitability. In cultured human cells, taurine, together with zinc and vitamin E, stabilizes cell membranes. It participates in detoxification reactions and functions as an antioxidant.
Trace Minerals. Zinc is linked to antioxidant functions in a variety of ways. It serves as a cofactor for copper/zinc dependent superoxide dismutase, the enzyme that converts superoxide to hydrogen peroxide. Zinc is a component of metallothionein, the most abundant zinc containing protein, which is believed to have a role in heavy metal detoxification. Zinc also stabilizes plasma membranes.
Selenium as selenocysteine serves as the cofactor for glutathione peroxidase, a group of enzymes that degrade cytoplasmic hydrogen peroxide and reduce fatty acid peroxides to stable forms.
Coenzyme-Q10, Emulsified. This lipid soluble nutrient is believed to protect mitochondrial membrane lipids from oxidation. It may also recycle vitamin E. As part of the electron transport system in mitochondria, coenzyme-Q10 plays an important role in oxidative phosphorylation. Suboptimal coenzyme-Q10 levels impair mitochondrial respiration and ATP production, especially in aging heart muscle. Clinical studies have shown that emulsification increases the efficiency of coenzyme-Q10 absorption by up to three fold.
Superoxide Dismutase. SOD is the primary enzymatic free radical scavenger of mammals. In fact SOD is the only enzyme specifically designed to disarm free radicals in the body. SOD catalyzes the conversion of superoxide to hydrogen peroxide and oxygen, thus converting oxygen radicals to less reactive forms of oxygen molecules. Three forms of SOD exist in animals: copper/zinc SOD occurs in the cytoplasm and another copper/zinc SOD occurs in blood and interstitial ?uid. This extracellular SOD is bound to the endothelium of blood vessels. Mitochondria contain manganese SOD, the third form of SOD. For these reasons, copper, zinc and manganese are considered antioxidant nutrients. A double blind, placebo controlled study indicates that orally ingested vegetable culture source SOD (proprietary product from Biotics Research Corporation) significantly increases erythrocyte SOD activity in humans.
Catalase plays a significant role in metabolism. Hydrogen peroxide produced from the action of SOD on superoxide remains a strong oxidizing agent and is one of the reactive oxygen species (ROS) found in the body. To cope with hydrogen peroxide production, cells contain a series of enzymes that convert hydrogen peroxide to oxygen and water. Peroxisomes contain catalase to dispose of hydrogen peroxide generated by peroxisomal metabolism. Thus, catalase compliments SOD activity. BioProtect supplies vegetable culture source catalase (proprietary product from Biotics Research Corporation).
Summary of Noteworthy BioProtect Features:
As in nature, BioProtect provides a wide array of antioxidants and synergists, ranging from vitamins and minerals to phytochemicals and enzymes, especially:
- Balanced, broad spectrum antioxidants and synergists
- Increased bioavailability: emulsified vitamins and cofactors vegetable culture trace minerals
- Natural mixed carotenoids, including lycopene
- Food form polyphenols
- Plant source superoxide dismutase and catalase.
Quality Control - What Sets Biotics Apart
The Biotics Research way!
At Biotics Research Corporation, we manufacture our own branded products on site, in our own state of the art facilities, allowing for complete control of the entire manufacturing process. In our on-site laboratories, the highly skilled members of our Quality Control Unit, utilize modern, sophisticated technologies and validated analytical methods to test incoming raw materials, monitor manufacturing processes, perform in-process testing, and test all finished products prior to their release for shipment. In fact, many aspects of our cGMPs (current Good Manufacturing Practices) exceed the new, recently enacted FDA guidelines for dietary supplements in order to ensure the safety and effectiveness of our products.
The Quality Control Unit (QCU) has the authority to approve and/or reject all specifications and procedures associated with the production and release of all raw materials, packaging materials and finished products, including test methods and results, instrument calibrations, and processing records. The QCU conducts all internal audits, and validates and audits all raw material and packaging suppliers and service vendors as well.
All incoming raw materials are subject to appropriate testing prior to their release for production. Tests conducted include identity, potency, biological activity, microbiological, including bacteria, yeast and mold (including aflatoxins) and heavy metals (arsenic, cadmium, lead & mercury). Retained samples are maintained of all raw materials and finished products for future testing requirements (raw material stability and finished product expiration date verification).
All bulk finished products (tablets & capsules) are inspected and subjected to metal detection prior to being sampled by QC. They are then subject to appropriate disintegration and/or dissolution testing, and potency testing prior to being released to packaging. All liquid and powder products are tested for potency prior to packaging as well. Finally, microbiological testing is performed on all finished products and document reconciliation is completed prior to being released for shipment.
All testing is performed by our trained QC personnel using state of the art laboratory instrumentation including High Pressure Liquid Chromatography (HPLC), ICP, Atomic Absorption Spectrophotometry (AA), gel electrophoresis, FT-IR, Ultra Violet spectrophotometry, Thin Layer chromatography and Gas Chromatography-Mass Spectrometry (GC-MS).
Unlike many companies that are struggling to meet the new GMP requirements established by the FDA, companies that are being regulated into implementing quality programs, extensive Quality Control has always been part of the corporate fabric of Biotics Research Corporation.
From day one, the mantra of Biotics Research Corporationhas been "Innovation and Quality." Our goals remain unchanged - utilize innovative ideas and carefully researched concepts with advanced techniques to develop products of superior quality and effectiveness - bringing you "The Best of Science and Nature".