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Biotics Research - Bio-Soy Flavones - 60 Capsules

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Biotics Research - Bio-Soy Flavones - 60 Capsules

  • Item# :107347
    UPC# :055146065030
  • Brand:Biotics Research
  • Size/Form:60  Capsules
  • Ship Weight:0.10
  • Servings:60
  • Dosage:1  Capsule(s)

Biotics Research Bio-Soy Flavones - 60 Capsules

Biotics Research Bio-Soy Flavones is a source of supplemental isoflavones for women experience symptoms such as hot flashes, commonly seen with low estrogen output associated with life's "transitional phase".

What are isoflavones?
Isoflavones are a family of flavonoid compounds, and as polyphenols they possess antioxidant properties typical of this group.  The prominent isoflavones of soybeans are genistein and daidzein together with lesser amounts of glycitein.  Although low levels of isoflavones occur in many seeds and legumes, by far the highest amounts occur in soybeans, which contain up to 1,000-3,000 micrograms of isoflavonoids per gram.  Typical of many flavonoids, soy isoflavones occur naturally as sugar derivatives (glycosides).  In this case, glucose is attached, creating glucosides (genistein + glucose = genistin, daidzein + glucose = daidzin, and glycitein + glucose =  glycitin).  Intestinal enzymes and bacteria cleave off glucose to yield the free isoflavonoids (aglycones), which are then absorbed and raise plasma levels.  Little is known regarding tissue concentrations of isoflavones and of flavonoids generally.  Once absorbed, it is believed that iso?avones are conjugated with glucuronic acid and undergo enterohepatic circulation.  The reduced iso?avone, equol, is not found in soy, rather it is formed from soy isoflavones by reduction of gut bacteria. 

Soy Consumption and Health
The Japanese have the highest plasma levels of isoflavones, especially genistein and daidzein.  The typical Western diet does not include soy protein or soy products and therefore lacks isoflavones.  With the exception of vegetarians, Americans have the lowest levels. A traditional Japanese diet provides approximately 50 mg of soy isoflavones daily, while the typical U.S.  consumption is less than 1mg/day.  Urinary excretion of isoflavonoids is proportional to dietary intake from the diet.  Adding soy to a Western diet can increase urinary isoflavone excretion by 1,000 fold. 

It has long been recognized that diets rich in soybased foods promote health and reduce the risk of chronic conditions.  Rats consuming a soy-based diet develop fewer mammary tumors following the administration of carcinogens.  Recent research provides insights into possible mechanisms that underlie soy’s health benefits.  The view is emerging that the effects of soy are more likely due to the concerted action of many phenolic compounds, including isoflavones, rather than due to single compounds.  Genistein, daidzein and glycitein are closely related compounds; however, their subtle chemical differences lead to somewhat different biological properties. 

Isoflavones Inhibit Enzymes
Isoflavonoids exhibit a wide range of effects which often can be traced to inhibition of key enzymes.  For example, daidzein inhibits 3 beta hydroxysteroid oxidation of testosterone, pregnenolone, estradiol and DHEA by steroid dehydrogenases.  The isoflavonoids inhibited testosterone metabolism by alpha reductase in prostate homogenates to the same extent as finasteride.

Genistein is a well established inhibitor of tyrosine kinases.  These enzymes are implicated in regulatory mechanisms affecting the cell cycle.  Tyrosine kinases modulate cell receptors for various growth factors and oncogene expression.  Tyrosine phosphorylation is involved in key regulatory mechanisms such as mitogen-activated protein kinases and phosphatidylinositol kinases, and these may be cellular targets for genistein.

Furthermore, activation of estrogen and progesterone receptors also respond to tyrosine kinases and therefore genistein may affect estrogen binding.  In addition, genistein inhibits topoisomerases, which regulates the cell cycle.

Isoflavones as Antioxidants
Isoflavones are antioxidants  in vitro and  in vivo.  They inhibit fat rancidity and they increase hepatic glutathione peroxidase activity in lab animals.

Isoflavones as Pseudoestrogens
Many studies have shown that is flavones bind to estrogen receptors.  Generally, binding is 1/500 to 1/1000 of that observed for estrogen.  Genistein can function as an estrogen agonist by competing with estrogen at its receptor sites over hysiologically relevant concentration ranges.  However, the effects of isoflavones at the cellular level may not be primarily due to estrogen receptor binding, although the actual mechanisms remain unknown.  Certain estrogen-like effects of soy have been reported.  Soy protein diets providing 45 mg isoflavones per day, decreased luteinizing hormone and follicle stimulating hormone, while increasing the follicular phase and delaying the onset of menstrual cycles in premenopausal women.

Soy and Menopause
Climacteric symptoms are relatively rare in China and Japan, and soy consumption may be a factor.  As an example, there was a reduction in hot flashes and vaginal dryness and an increase in sex hormone binding protein in women who consumed soy.  Premenopausal women consuming 20 gm soy protein containing 20 mg genistein experienced reduced symptoms such as hot flashes associated with low estrogen output.

Soy and Bone Health
Hip fractures are much less common in Asia than in the U.S., although osteoporosis is becoming more prevalent in Japan with a shift from the traditional diet to a westernized diet and a reduction in soy-based foods.  A variety of animal studies have suggested that the consumption of soy protein with isoflavones or genistein can increase bone density, decrease calcium excretion and/or reduce bone losses.  Animal studies  suggest that a soy protein diet helped maintain bone density in ovariectomized lab animals.

Soy and Cardiovascular Health
It as long been known that soy consumption can lower plasma lipids.  A recent meta analysis of studies indicates that substituting animal protein with soy protein at a level of 25-30 grams daily significantly decreased the serum concentrations of cholesterol, LDL cholesterol and triglycerides. The mechanism is unknown, possibly isoflavones play a role, and it is estimated that soy phytoestrogens.

Quality Control - What Sets Biotics Apart

The Biotics Research way!

At Biotics Research Corporation, we manufacture our own branded products on site, in our own state of the art facilities, allowing for complete control of the entire manufacturing process. In our on-site laboratories, the highly skilled members of our Quality Control Unit, utilize modern, sophisticated technologies and validated analytical methods to test incoming raw materials, monitor manufacturing processes, perform in-process testing, and test all finished products prior to their release for shipment. In fact, many aspects of our cGMPs (current Good Manufacturing Practices) exceed the new, recently enacted FDA guidelines for dietary supplements in order to ensure the safety and effectiveness of our products.
The Quality Control Unit (QCU) has the authority to approve and/or reject all specifications and procedures associated with the production and release of all raw materials, packaging materials and finished products, including test methods and results, instrument calibrations, and processing records. The QCU conducts all internal audits, and validates and audits all raw material and packaging suppliers and service vendors as well.

All incoming raw materials are subject to appropriate testing prior to their release for production. Tests conducted include identity, potency, biological activity, microbiological, including bacteria, yeast and mold (including aflatoxins) and heavy metals (arsenic, cadmium, lead & mercury). Retained samples are maintained of all raw materials and finished products for future testing requirements (raw material stability and finished product expiration date verification).

All bulk finished products (tablets & capsules) are inspected and subjected to metal detection prior to being sampled by QC. They are then subject to appropriate disintegration and/or dissolution testing, and potency testing prior to being released to packaging. All liquid and powder products are tested for potency prior to packaging as well. Finally, microbiological testing is performed on all finished products and document reconciliation is completed prior to being released for shipment.

All testing is performed by our trained QC personnel using state of the art laboratory instrumentation including High Pressure Liquid Chromatography (HPLC), ICP, Atomic Absorption Spectrophotometry (AA), gel electrophoresis, FT-IR, Ultra Violet spectrophotometry, Thin Layer chromatography and Gas Chromatography-Mass Spectrometry (GC-MS).

Unlike many companies that are struggling to meet the new GMP requirements established by the FDA, companies that are being regulated into implementing quality programs, extensive Quality Control has always been part of the corporate fabric of Biotics Research Corporation.

From day one, the mantra of Biotics Research Corporationhas been "Innovation and Quality." Our goals remain unchanged - utilize innovative ideas and carefully researched concepts with advanced techniques to develop products of superior quality and effectiveness - bringing you "The Best of Science and Nature".

One (1) capsule each day as a dietary supplement or as otherwise directed by a healthcare professional.

Biotics Research - Bio-Soy Flavones - 60 Capsules
Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 60
Amount Per Serving %DV*
Soy Isoflavones 50mg *
Superoxide Dismutase 15mcg *
Catalase 15mcg *
*Daily Value Not Established.
†Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
Other Ingredients: Gelatin, water, glycerin and vegetable culture (specially grown, biologically active containing naturally associated and/or orgnically bound phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperatures to preserve associated enzyme factors).
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About Biotics Research

Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

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*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.