Nutramax Labs Samsyl Liver Health Support - 45 Capsules
Nutramax Labs Samsyl Liver Health Support is a patented, dietary supplement containing a pure, stabilized, and naturally derived S-adenosylmethionine (SAMe) with a highly bioavailable (absorbable) silybin-soy phosphatidylcholine complex used for liver health.
The liver plays a key role in metabolism, mainly transforming harmful substances into by-products for elimination from the body. As such, the liver is continuously exposed to many toxic substances, including free radicals. An unhealthy liver can result from a compromise in local antioxidant capabilities (i.e. – decreased liver glutathione levels).
- Normalizes Hepactic Enzymes
- Increases Hepatic Glutathione
- Protects Hepatic Tissue
SAMe is a molecule synthesized by cells throughout the body and is particularly important in liver cells (hepatocytes) because of their central role in metabolism. SAMe has roles in cellular protection, regulating the inflammatory response, promoting cell synthesis, and improving liver function. As an example, low glutathione levels are common in those with decreased liver function. SAMe, a glutathione precursor, has been shown to increase hepatic glutathione levels, protecting hepatic tissues. Supplemental SAMe improves hepatocellular function without cytotoxicity or significant side effects.
Silybin is an active component of the milk thistle extract from the fruit Silybum marianum and its absorption is enhanced by soy phosphatidylcholine. Silybin, as found in Samsyl® in the form of Siliphos®, has been shown in a pilot study to have beneficial effects on liver function. Silybin has many different mechanisms of action. Animal and human in vitro and in vivo studies have shown that it protects against oxidative stress; promotes hepatocyte protein synthesis, a mechanism for liver cell regeneration; inhibits leukotriene production, which can be beneficial as production of leukotrienes is a component of the inflammatory response; stimulates the flow of bile acid and the production of bile salts which aid in digestion and absorption of nutrients; and increases levels of glutathione.
- Supports liver health
- Contains a unique, scientifically formulated blend of pure and stabilized S-adenosylmethionine (SAMe) along with a silybin-soy phosphatidylcholine complex
- 2 highly bioactive ingredients; 1 unique, patented formula
- Easy to swallow capsules
Why use Samsyl® versus other supplements?
Samsyl contains highly bioactive forms of SAMe and sylibin and is continually assessed through quality control testing to confirm the amount stated on the packaging is found in each capsule sold. To support liver health it is important that supplemented SAMe be provided in a composition that has the highest effectiveness. Samsyl principally contains a naturally derived SAMe S,S isomer, the predominant form found in our liver cells. The silybin-soy phosphatidylcholine complex found in Samsyl has superior bioavailability compared to standard milk thistle extract, resulting in increased absorption in the gastrointestinal tract.
About Nutramax Laboratories, Inc.
At Nutramax Laboratories, Inc. they believe that their products should be backed by science. Their commitment to research is shown by their state-of-the-art research facility that allows us to investigate how their product ingredients work – their mechanisms of action. They also support studies including efficacy (ability of products to produce desired effect), bioavailability (absorption) and safety.
Oxidative balance overview:
Oxidative balance is the balance between levels of "oxidants" (you may also have heard these referred to as "free radicals" or "reactive oxygen species"), which are highly charged oxygen compounds that negatively can alter cells, and "antioxidants" – substances that can counteract or inhibit the destructive effects of free radicals. Antioxidants include vitamin C, E, beta carotene, glutathione and many others. Glutathione in particular is a small molecule made up of three amino acids, which are the building blocks of proteins.
Oxidative imbalance results from too many oxidants with not enough antioxidants to work against them. You may have heard of this phenomenon referred to as "oxidative stress". Many things, including aging, medications, conditions in our body that negatively affect health (i.e. – chronic viral infections), pollution, and exposure to the sun can lead to this imbalance. Oxidants are produced normally in the body within our cells. During periods of imbalance, however, oxidant levels in our cells may build up allowing them to negatively react with cell membranes, DNA, and proteins.
In vitro and in vivo studies:Frequently Asked Questions About Samsyl
In vitro refers to research on typically macromolecules (i.e. – DNA, RNA, proteins) that are isolated from cells while in vivo refers to research generally undertaken using a whole, living organism or cultured cells.
What is Samsyl®?
Samsyl® is a patented dietary supplement that supports liver health. It contains a combination of pure, stabilized, and naturally derived S-Adenosylmethionine and the highly bioavailable silybin soy-phosphatidylcholine complex, Siliphos®. Each capsule contains 267 mg of S-Adenosylmethionine with 80 mg of Siliphos®.
Why does Samsyl® contain both S-Adenosylmethionine and Silybin?
The combination of SAMe and silybin in Samsyl provides a multi-faceted approach to liver support. Deficiencies of SAMe can contribute to negative effects of cell function and structure in the liver and throughout the body. Supplemental administration of SAMe has been shown to result in improvements in hepatocellular function without cytotoxicity. Silybin, as found in Samsyl in the form of Siliphos®, has been shown, in a pilot study, to have beneficial effects on liver function.
What are the benefits of supporting my liver health with Samsyl®?
The liver plays a key role in metabolism, mainly transforming harmful substances into by-products for elimination from the body. As such, the liver is continuously exposed to many toxic substances, including free radicals. An unhealthy liver can result from a compromise in local antioxidant capabilities (i.e. – decreased liver glutathione levels). Samsyl helps to normalize hepatic enzymes, increase hepatic glutathione levels, and protect overall hepatic tissue.
Can Samsyl® be taken in conjunction with other supplements or prescription medications?
As is the case with all supplements and medications, those taking Samsyl should consult with their physician when planning on taking this product along with prescription medications. Individuals with bipolar disorder (manic depressive illness) should not take this or any other product containing SAMe except under a physician’s supervision.
Are there any potential side effects with Samsyl®?
The active ingredients in Samsyl (i.e. – SAMe and Silybin) are generally well tolerated. Assessments of oral administration of Samsyl via an LD50 study revealed no toxicity. Side effects associated specifically with SAMe are generally mild however there is the potential for any product containing SAMe to interact with other medications that can raise serotonin levels. Thus, Samsyl should not be taken concurrently with any medications for depression or bipolar disorder, including monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) except under a physician’s supervision. Side effects associated specifically with silybin are generally mild. Again, as is the case with all supplements and medications, allergic reactions are uncommon but may occur. Those suspecting they may have an allergic reaction should consult their physician.
Does Samsyl® offer benefits for mood or joint support?
Currently, the ingredients used in Samsyl are formulated and labeled for liver health support. Please consult your physician before using this product for other benefits.
Is there a similar product available for my pets?
Yes. Denamarin®, available through your veterinarian for both dogs and cats, is produced by the same manufacturers as Samsyl, Nutramax Laboratories, Inc.