Ortho Molecular Products - Botanicalm PM - 60 Capsules
Ortho Molecular Products Botanicalm PM Endocrine Health is formulated to induce the relaxation needed to support better sleep for those experiencing temporary sleeplessness. The formula is especially suited to help those with difficulty falling asleep due to restlessness.
- Supports Restorative Sleep
- Helps Induce Relaxation
- Supports Positive Mood
Busy and stressful lifestyles can cause sleep patterns to become disrupted, leading to over-stimulation and restlessness. Gamma-aminobutyric acid (GABA) is the brain's primary neurotransmitter which helps to counteract stress by promoting a sense of relaxation. In the evening, GABA activity should increase in the brain, triggering the sleep cycle. The ingredients in Botanicalm PM work in synergy to support GABA activity and allow for optimal relaxation.
Botanicalm PM includes valerian root, a well-known herb used to help with sleep-related issues and to produce a state of relaxation. Passionflower and jujube have been used historically to produce a state of relaxation, and have been used in those with overstimulation and scattered thoughts. L-theanine, an amino acid found in green tea, supports resilience to stress by increasing alpha brain wave activity. Two capsules of Botanicalm PM include 450 mg valerian root extract, 200 mg jujube seed extract, 150 mg passionflower extract, 150 mg L-theanine and 100 mg hops strobile extract.
Valerian Root Extract
Valerian root extract is perhaps the most studied botanical for inducing sleep. Valerenic acid, an active component in valerian root, has spasmolytic or muscle relaxant properties. It has been found to both inhibit the reuptake of and stimulate the release of GABA in the central nervous system (CNS). In addition, other components within valerian have been found to bind to GABA receptors. Randomized trials consistently show significant benefits to supplementing valerian over placebo. One randomized, double-blind, placebo-controlled trial comparing 600 mg/day of valerian extract given with another therapy for six weeks showed valerian root extract to be equally effective in supporting sleeplessness as a traditional approach.
The aerial portions of passionflower are best known for their historic use as a relaxing and calming herb. Numerous flavonoid components function as active ingredients by binding to the GABA receptor. Passionflower extract has compared favorably with other therapies with similar mechanisms of easing feelings of overstimulation and scattered thoughts, with fewer side effects. A randomized, placebo-controlled trial of 60 people, aged 25-55 years and scheduled for spinal anesthesia, showed those given passionflower experienced a greater sense of calmness before being given anesthesia. Passionflower has also been shown to offer sleep benefits for adults with fluctuations in sleep quality.
L-theanine is an amino acid found in green tea, and is considered a relaxant (although not a sedative) when used alone. The Food and Drug Administration has approved several health claims for L-theanine including: stress reduction, relaxation without drowsiness, decreased nervousness from common fatigue, and reduced nervous irritability. L-theanine has been shown to significantly increase alpha brain wave activity which correlates with a perceived state of relaxation.
Wild jujube seed has been historically used in traditional Chinese medicine as a sedative herb. It has been shown to reduce stress, conserve energy and promote sleep. It is useful for those with symptoms of nervous exhaustion, fatigue, irritability and the inability to sleep (Note: Most research on the active components [jujubosides A and B] for sedative and CNS function has been performed in China and are written in Chinese).
Hops Strobile Extract
The hops plant, Humulus lupulus, is a perennial climbing vine that has been used for centuries for its relaxing properties, among other health benefits. Only the female hops, which produce flowers known as strobiles, are used for medicinal purposes. The active ingredients in hops include a volatile oil, valerianic acid, tannins and flavonoids. European studies have examined the effects of hops in combination with other sleep-supporting botanicals. In a pilot study that included 30 subjects with mild-to-moderate sleep challenges, a preparation combining 500 mg of valerian extract with 120 mg hops was given to subjects 30 minutes before bedtime. The hops-valerian preparation was found to improve sleep quality by decreasing sleep latency and wake time throughout the night.
The Ortho Difference
Quality Beyond What's Expected
Following are just some of the steps Ortho Molecular Products takes to ensure the quality of their formulas:
- Ortho Molecular follow rigid SOPs (standard operating procedures) and MOPs (methods of procedure) throughout every stage of production, leaving nothing to chance.
- They test all incoming raw materials in their state-of-the-art, in-house laboratory for identity (Is the material what it says it is?), purity (Does it contain any contaminants?), and composition (Does it match expected specifications?).
- Ortho Molecular mix all of their raw materials in dedicated blending rooms using a custom-made 5,000-liter mixer following strict protocols to ensure product consistency.
- They manufacture every batch of product in dedicated tabletting and encapsulating rooms, which are thoroughly cleaned and dried after each batch is made to protect against cross-contamination. It can take up to eight hours just to clean one room!
- Ortho Molecular perform thorough post-cleaning inspections to ensure the highest state of sanitation has been achieved.
- They test all finished products for identity (Does the formula contain the correct ingredients?), strength (Are the ingredients present in the potencies claimed?), and purity (Does the formula contain any contaminants?).
- Ortho Molecular subject every new formula to stability testing, which involves assaying ingredients to detect any degradation at 6-month intervals, thus ensuring the formula meets label claim at expiration.
Manufacturing To A Higher Standard
These days, most dietary supplement companies are really sales and marketing firms. While they may formulate their own products, it is standard to outsource the manufacturing, laboratory testing, bottling, and labeling to a big contract manufacturer. The upside to this practice is that it's convenient. The downside is that companies lose control to others that don't share the same passion for the quality of the products.
Ortho Molecular Products is unique in that they operate their own 100,000-square-foot, cGMP, FDA-audited manufacturing facility that is based in Stevens Point, Wisconsin and staffed by highly trained personnel who share a passion for efficacy. Because we control the entire production process - from formulation…to raw materials sourcing…to manufacturing…to laboratory testing of incoming materials and finished product…to bottling and labeling - they are free to be perfectionists.
Ortho Molecular Products manufacturing facility is strictly controlled by rigorous standards that meet cGMPs, and it routinely passes FDA and third-party audits. Extensive testing on every product we manufacture means you can trust the consistent purity, strength, identity, and composition of each and every Ortho Molecular Products formula.
It's rare for a supplement company to handle all phases of production. But when your standards are as high as theirs, you don't want to entrust it to anyone else.
About Ortho Molecular Products
There are many choices in the dietary supplement market an overwhelming number of companies selling a dizzying array of products, all promising results. As a health care practitioner making recommendations to your patients, you feel a responsibility to sort through those options and find the best products to support the health of those who have put their trust in you.
The Power of e is their commitment to efficacy that produces the highest possible levels of patient wellness. From raw-material selection, all the way to the finished products they manufacture, everything Ortho do is guided by the goal of achieving greater efficacy. Ortho Molecular Products are proud of their 25 year tradition of successfully combining evidence-based formulations and superior raw ingredients to develop efficacious supplements that noticeably enhance patient health.