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4 oz.
Item #
Ship Weight
0.15 Lb(s)


    OxyRub - Dr. Pergolizzi Pain Relief Cream - 4 oz. (114 g)

    Oxy Rub Dr. Pergolizzi's Pain Relief Cream provides rub on fast relief for arthritis, bursitis, back pain, tendonitis, muscle aches, and more. Developed by renowned pain physician and researcher, Dr. Joseph Pergolizzi, OxyRub Pain Relief Cream works in minutes, stimulating circulation immediately, and easing your pain with exceptional effectiveness.

    • Clinically tested and shown to deliver nearly 2X the pain relief of a leading pain cream
    • Provides fast relief from arthritis, bursitis, aches, bruises, and joint pain
    • Absorbs into skin in minutes with no irritation or lingering medicinal scent
    • Safe to use every day—no prescription required!

    Ancient Discovery, Modern Clinical Results

    In Biblical times, stories abounded of a mysterious oil used by ancient healers. It was said to be a precious and wonderfully soothing elixir. Traditionally, this miraculous oil was made by leaving an essential oil in an open vat for 20 years, allowing the sun’s rays to infuse the oil with oxygen.

    Today, modern science has rediscovered the power of super-oxygenated oil, and the oxygenation process has been shortened to just 3 days. Athletes in Europe have been using this oil for years, but it took leading pain expert Dr. Joseph Pergolizzi to bring it home to the US and create the formula for OxyRub Pain Relief Cream.

    Now, this exact formula has been clinically shown to provide nearly double the relief of a leading menthol-based pain cream—quickly, and without any medicinal odor. You, too, can enjoy the soothing powers of this ancient secret when you use OxyRub Pain Relief Cream to relieve joint and muscle pain.

    Human Clinical Trial Confirms Powerful Relief

    OxyRub Pain Relief Cream was recently tested in a randomized, double-blind clinical trial (the "gold standard" of medical research).

    Half of the participants received OxyRub, and the other half received a leading, best-selling brand of menthol pain cream.

    The trial took place over 8 days, partly because researchers wanted to see if the initial pain relief might wear off with extended use. But it didn’t! With OxyRub, pain relief actually increased with each additional day of use. And after 8 days, participants using OxyRub felt nearly twice the pain relief of those using the popular menthol cream.

    Your OxyRub Questions Answered

    How is OxyRub better than the other over-the-counter menthol creams?
    OxyRub is a unique blend of pain-relieving menthol and rich, oxygenated essential oil, which Dr. Pergolizzi believes is the “secret ingredient” to the formula and its efficacy.  And the science backs it up—OxyRub has been clinically studied and found to provide nearly twice the pain relief of the leading menthol-based pain cream.

    What is the clinical evidence behind this product?
    OxyRub (with 1.25% menthol) was compared to a leading pain cream (also with 1.25% menthol) in a clinical study. This was a double-blind, randomized, controlled head-to-head study of two topically applied analgesics for treatment of acute musculoskeletal pain in 75 normal healthy adults.  By day 8 of treatment, the OxyRub group reported a 59.5% decrease in pain while the other group reported a 32.3% decrease (compared to before using their creams).  This was almost double the pain relief with the OxyRub group.  The study also showed that pain started to decrease 30 minutes after application of OxyRub.

    Who is Dr. Pergolizzi?
    Dr. Joseph Pergolizzi, Jr., is an Adjunct Assistant Professor at Johns Hopkins University School of Medicine, an Adjunct Associate Faculty at Temple University School of Medicine, and Adjunct Faculty at Georgetown University School of Medicine. He started his career as a chemist, but his focus became pain, which is the #1 reason people seek medical care. His patients include other doctors, athletes, members of law enforcement, and other sufferers of acute and ongoing pain. He is the co-founder of the International Pain Research and Treatment Foundation, a member of the board of directors of the National Institute of Pain, and a founding member of Change Pain, a Pan-European organization that educates over 200,000 doctors on a quarterly basis. He is currently seeing patients at the Naples Anesthesia & Pain Associates Group of Southwest Florida in Naples, FL.

    Why did Dr. Pergolizzi create this product?
    Dr. Pergolizzi wanted to develop an effective pain relief product that could be easily accessible by people with all types of pain and one that is safe, works quickly and is long lasting.  He developed OxyRub,  a topical pain cream that has been clinically researched and shown to be a fast-acting, deep-penetrating, long-lasting pain reliever that can be used to help relieve sore muscles, muscle strains, back pain, shoulder pain, neck pain, and joint pain associated with arthritis, tendinitis, bursitis, sprains and other issues.

    As reported in a recent Pain Week survey, over 90% of pain practitioners now recommend topicals as a first line of defense against pain.  OxyRub is an effective first choice for helping quickly ease almost any type of pain.

    OxyRub Pain Cream has a pleasant smell and is rapidly absorbed for fast relief. OxyRub contains menthol, in a base of oxygenated essentials oils, and is available without the need for a prescription and is safe to take with all other pain relievers (prescription, OTC, or natural).

    Who should use OxyRub?
    This product is for adults and children 12+ years of age who are looking for a safe way to relieve their joint, muscle or other pain.

    What benefits should I expect from this formula?

    • Temporarily relieves minor aches and pains of muscles and joints associated with back aches, arthritis, strains, sprains, tendinitis, bursitis, and bruises
    • Provides quick, effective relief of sore muscles and joints
    • Helps to soothe and relieve back pain
    • Clinically shown to relieve pain better than the leading pain cream
    • Deep, rapid absorption helps relieve pain quickly. Helps relieve pain in all of the following areas: back, neck, and shoulder pain; finger, hand, and wrist pain; foot, ankle and knee pain; sprains and strains
    • Contains essential oils, which absorb quickly and help induce oxygen into the skin to stimulate healing and circulation
    • Use before and after workouts, massages, or anytime to invigorate and relieve muscle soreness
    • PABA free, not animal tested, no animal products, no steroids

    How quickly should I expect to feel relief with OxyRub?
    OxyRub users report feeling cooling relief within just a few minutes of applying the cream to the affected area.  Significant relief was noted after 30 minutes in a clinical trial, and over the course of the 8-day trial, relief increased with each subsequent day of usage.

    Are there any side effects associated with this product?
    There are no known side effects. However, as with any topical product, there may be isolated allergic reactions if someone is allergic to one of the ingredients in the product.

    Can I take this product with my prescription, over-the-counter, or other pain relief products?
    Yes, because this is a topical product, in can safely be used in combination with other pain relievers (prescription, over-the-counter, or dietary supplements).

    How and when should I use this product?
    Use enough cream to cover the area(s) where you have pain. For example, a quarter sized amount is sufficient for covering the knee.  Apply to affected area no more than 3 to 4 times daily.

    About Dr. Joseph Pergolizzi
    OxyRub Pain Relief Cream was formulated by Dr. Joseph Pergolizzi, World-Acclaimed Pain Relief Doctor.

    • Dr. Pergolizzi is an actively practicing physician, treating thousands of patients every year in his advanced Florida practice
    • A highly sought-after pain relief instructor, serving as an adjunct faculty member at major medical universities
    • Author of over 100 peer-reviewed articles, abstracts, platform presentations, and book chapters in his areas of expertise
    • Recently named "One of America’s Most Compassionate Doctors" and winner of the 2012 Patient’s Choice Award

    All my career, I’ve been researching pain and teaching pain relief to other doctors. Now I’m proud to present OxyRub Pain Relief Cream, my biggest contribution to pain relief yet. —Dr. Pergolizzi


    Adults and children 12 years of age and older. Apply to affected area no more than 3-4 times daily. Children under 12 years of age, consult a doctor.

    Store at room temperature. For Lot Number and Expiration Date, see crimp at end of tube.


    Drug Facts
    Active Ingredient Purpose
    Menthol (1.25%) Topical Analgesic
    Inactive Ingredients
    Bitter Orange Oil, C13-14 Isoparaffin, Caprylhydroxomic Acid, Caprylyl Glycol, Eucalyptus Oil, Glycerin, Laureth-7, Oxidized Corn Oil, Polyacrylamide (1000 MW), Polysorbate 20, Water


    For external use only. Use only as directed.

    Do not use

    • with a heating pad, may blister skin
    • on open wounds or damaged skin

    Ask a doctor before use if you have redness over the affected area.

    When using this product

    • avoid contact with eyes
    • do not bandage tightly

    Stop use and consult a doctor if

    • skin redness or excessive skin irritation develops
    • condition worsens or symptoms persist for more than 7 days
    • symptoms clear up and occur again in a few days

    Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.



    About Dr. Joseph Pergolizzi OxyRub Pain Relief Cream was formulated by Dr. Joseph Pergolizzi, World-Acclaimed Pain Relief Doctor.

    Reviews (6)

    5 out of 5 stars
    6 Reviews
    5 Stars
    4 Stars
    3 Stars
    2 Stars
    1 Stars

    100% 6 of 6 reviewers would recommend this product to a friend.

    By (Rockville, MD)

    A bit on the expensive side but a good product that seems to have positive results on sore muscles after swimming workouts.

    Was this review helpful?

    • YES: 2
    • NO: 3
    By (Flat Rock, MI)

    This product really works. I don't have to use it every day to keep the pain away. Works best after taking a hot shower. Great product.

    Was this review helpful?

    • YES: 1
    • NO: 0
    By (Belvidere, IL)

    Received my order quickly and put the Oxy Rub to immediate use to relieve muscle pains. Your site offered me the best price of those that I checked.Thanks.

    Was this review helpful?

    • YES: 1
    • NO: 0
    By (Yukon, OK)

    My order was shipped in a timely manner and Lucky Vitamin kept in touch with me often. Oxy Rub relieved my pain. It is so hard to find it out here so I was thankful that I could order it. It does work wonders!

    Was this review helpful?

    • YES: 0
    • NO: 0
    By (Porterville, CA)

    works well!!!

    Was this review helpful?

    • YES: 0
    • NO: 0


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