Doctors Best Curcumin Phytosome featuring Meriva 500 mg - 60 Vegetarian Capsules

Doctors Best Curcumin Phytosome featuring Meriva nutrients (curcumin, demethoxycurcumin, bisdemethoxycurcumin) are usually poorly absorbed when taken by mouth. Phytosome proprietary technology solves this problem. In Doctors Best Curcumin Phytosome featuring Meriva, each curcuminoid molecule is individually complexed with molecules of the vital cell membrane nutrient phosphatidylcholine (PC). By facilitating curcumins' entry into human cells and tissues, PC gives this product superior bioactivity over non-phytosome curcumin supplements.

• Science-based nutrition
• Dietary supplement
• Deliver curcuminoids with enhanced stability and superior bioactivity
• Promote healthy functioning of the joints and other organs
• Support healthy management of C-reactive protein

The curcumin nutrient complex is unique for its diverse benefits to human health. Produced from turmeric root, a traditional food for thousands of years, the complex of curcumin, demethoxycurcumin and bisdemethoxycurcumin is under intensive research scrutiny. Yet most curcumin dietary supplements have limited potency, due to their very poor absorption when taken by mouth. Doctors Best Curcumin Phytosome featuring Meriva uses patented Phytosome technology to dramatically improve the curcumins' absorption and unleash their total health potential.

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Phytosomes Naturally Enhance Curcumin Biological Activity
Phytosomes are molecular complexes formed between individual curcumin molecules and molecules of phosphatidylcholine (PC). Curcumin molecules normally mix very poorly into water and also are quickly destroyed by the water medium. Curcumins formed into phytosomes with PC disperse almost completely into water, and when taken by mouth are far better absorbed into the blood than are conventional curcumin supplements. In addition, the Phytosome technology also harnesses the additional health benefits of PC itself.

Taken daily as a dietary supplement, the curcumin-PC phytosome combination can:

• Measurably enhance the benefits of the curcumins.
• Protect the curcumins against premature molecular breakdown.
• Promote healthy functioning of the joints and other organs.
• Support healthy management of C-reactive protein, a bloodborne health indicator.

The Phytosome technology involves wrapping each curcumin molecule with one or more molecules of PC. This envelope of PC helps the bound curcumin molecule disperse in the water phase while shielding it against water damage. Researchers believe that once the phytosome supplement is swallowed, the unit phytosomes readily diffuse through the intestinal contents, facilitated by PC's excellent miscibility with water. After a phytosome arrives at an intestinal lining cell, the PC molecule readily merges with the outer cell membrane and the curcumin molecule passes into the cell interior. Subsequently the intestinal cells release the curcumins into the circulating blood, from which they travel to the other tissues.

Another attribute of Phytosome technology is that more than being just the delivery vehicle, PC is an important substance for life. PC is a phospholipid (pronounced fos-fo-lip-id) that was one of the first "health foods," and multiple clinical trials have documented PC's support for liver, intestinal, lung and circulatory health. PC's clinical benefits derive mainly from its central role in cell membranes, the main driving force for all cells. Once absorbed, curcumin also gets into cell membranes.

Phytosome Curcumins Support Key Cell Membrane Functions
Cell membranes are our cells' dynamic action zones. These are the structures that generate energy in the cell and utilize this energy to support virtually all the important life processes. They are continuous, uninterrupted sheets of molecules, strong yet flexible. The membrane's foundation or matrix is always composed mostly of PC molecules, between which are inserted most of the cell's catalytic, "can-do" proteins in the forms of receptors, signal transducers, and various other versions of enzymes.

PC is a universal building block for cell membranes. PC is essential for assembling, maintaining and repairing the membrane matrix, which in turn ensures the structural and functional competence of the entire cell membrane system. Vital to all life processes, PC has been called a Vital Lipid for Life. Numerous experimental and clinical studies document that PC helps preserve cell membrane systems against toxic or viral attack. And as curcumin enters the cell it specifically binds to the PC in the membrane. This is strong indication that these two nutrients complement each other's actions to fundamentally support cell membrane competence.

The curcumins are potent cell membrane protectants. They are versatile antioxidants that help prevent "free-radical" damage from oxygen and nitrogen-centered oxidants. The curcumins inhibit free radical attack on the cell, whether on the DNA and genes, on the mitochondria that generate energy, or on the membrane system. Membranes are especially vulnerable to free radical attack, and the presence of curcumin helps guard them against destruction from lipid peroxidation. The curcumins' protective capacities extend even beyond their antioxidant actions, as evidenced from their capacity to protect joint tissues against runaway destructive activity of the body's immune system.

Meriva Phytosomes Are Markedly Superior for Curcumin Delivery
Studies with both rats and humans demonstrate that dietary supplementation with the curcumin-PC phytosome results in dramatically higher blood (that is, plasma) curcumin levels, as compared to other curcumins consumed in non-phytosome, conventional molecular forms.

For the rat study, rats were fasted overnight then were force-fed equivalent amounts of curcumin either as phytosome or non-phytosome material.4 Blood samples were obtained at 0, 15, 30, 60, or 120 minutes after feeding. The phytosome preparation showed superior curcumin absorption into the plasma, beginning at 30 minutes. For the period 0-120 minutes, curcumin was absorbed some times better from phytosomes versus non-phytosomes. Further, the liver accumulated significantly more curcumin from the Meriva phytosome versus the non-phytosome preparation.

In human subjects, the Meriva curcumin was about 10 times better absorbed, compared to non-phytosome curcumin.14

Clinical Proof Meriva Supports Joint Health
In a recent double blind human trial, Meriva supported healthy joint function and down-regulated molecular triggers of tissue damage. The most favorable indicator of Meriva's benefit in this trial was treadmill performance. After 2 months on Meriva, the average distance walked at a brisk 3 kilometers per hour, with a treadmill incline of 10 percent, was significantly improved as compared to placebo. This impressive human finding on joint support was consistent with other positive findings from controlled studies with horses and dogs. In these veterinary studies, the identical phytosome preparation improved joint health and lowered TNF (tumor necrosis factor), a cytokine messenger molecule known to trigger damage to the joints and other tissues.

In experiments with cultured cells, which bypass bioavailability limitations since the curcumins can be added to the culture at any desired concentration, the curcumins support processes that favor joint building while opposing those processes that favor joint breakdown. The curcumins also down-regulated immune system cytokine messengers linked to joint tissue breakdown, most notably TNF, IL-1B (Interleukin-1 beta) and IL-6 (Interleukin-6). At a higher level of control, the curcumins also down-regulated NF-kB (Nuclear Factor-kappa B) and AP-1 (Activating Protein-1), master regulators of the genes that code for COX-2 (cyclo-oxygenase 2), lipoxygenases and other joint-destroying enzymes.

The key to success in the human double-blind trial was Meriva's measurably superior delivery of curcumins to the tissues. This trial also demonstrated that Meriva could significantly down-regulate C-reactive protein (CRP), a clinically relevant indicator of whole-body health as well as joint health.

Meriva Supports Healthy CRP Management
C-reactive protein is produced by the liver and released into the blood, and "highly-sensitive" blood CRP level (hs-CRP) is increasingly employed as a "biomarker" particularly for cardiovascular health. Blood hs-CRP normally is very low in healthy individuals, but predictably becomes increased when the immune system is active against tissue damage. Substantial clinical research indicates that low blood CRP is consistent with relatively good health and conversely, that elevated CRP is a harbinger of impaired function. In the human Meriva trial, those subjects who received Meriva had a marked lowering of their elevated CRP levels after 2 months. This was a statistically significant benefit as compared to the placebo group, which experienced no appreciable lowering of CRP.

Curcumin and its related curcumins from turmeric root have been a revered traditional cure-all for millennia. Modern science and clinical medicine has objectively verified a great many of these traditional folk applications. Now that the curcumins can be effectively delivered to the human tissues via Phytosome technology, their benefits observed experimentally are now available to all. For improved wellbeing and for optimal health long-term, Meriva Phytosome Curcumins is the "gold standard" of curcumin dietary supplements.

Doctor's Best Quality Standards

Quality Standards
Doctor's Best produces products with the highest quality raw materials available on the market. How? They have direct control over and are an integral part of every aspect of product production, from formulation and raw material sourcing to finished product manufacturing. They directly purchase all active ingredients used in our products and use only the highest quality ingredients.

Science Based Formulations
Every product is thoroughly researched and backed by the latest scientific studies conducted in the field. Their formulations reflect the amounts of ingredients shown to be beneficial based on the results of scientific investigations. They use patented, trademarked ingredients backed by scientific studies and clinical research. We never use insignificant quantities to enhance the label.

Raw Materials
Doctor's Best directly purchases only the highest grade raw materials from proven and reputable suppliers to be put into product formulations. All raw material suppliers go through our stringent vendor qualification process, which includes a multi-step investigation including all aspects of the production and handling procedures, to insure the highest level of quality is reached.

Finished Product
Whether producing a product with one raw material component or many, each finished product is held to the highest cGMP standards and produced under rigid quality control points to ensure product safety, potency, and uniformity. Their rigorous quality assurance and control processes ensure our customers receive only the highest quality nutritional products that exceed industry standards and provide exceptional nutrition benefits.

Quality Promise
Doctor's Best never compromises on ingredients, quality, or science. As a privately owned, independent entity, their answer only to our customers and the retailers who carry our products. They all depend on the integrity of the people and products with whom they deal. Since the day they went into business more than 17 years ago, Doctor's Best has pledged itself to that policy. The bottom line is, if Doctor's Best offers it, it's a proven nutritional concept with genuine health benefits.

About Doctors Best

Doctor's Best firmly believes in the integration of science research and traditional wisdom as the way that nutritional and herbal supplements will reach their exciting potential.

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor's Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation.

Containing the finest quality raw materials from around the world, Doctor's Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace.

Each of their products is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

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