Life Extension Garcinia HCA - 90 Vegetarian Capsules
HCA (hydroxycitric acid) is a close relative of citric acid, the agent that gives citrus fruits their characteristic tart flavor. HCA occurs in Garcinia cambogia, a small fruit from southern India, where it has been used for centuries as a food preservative, flavoring agent, and digestive aid. Life Extension Garcinia HCA is a safe, natural supplement for weight management. It has been suggested that Life Extension Garcinia HCA promotes weight loss by increasing serotonin levels, reducing hunger and appetite, and suppressing carbohydrate conversion into fat by inhibiting ATP-citrate lyase, thus regulating fat and obesity related genes. HCA may also attenuate the increases in oxidative stress, and insulin resistance.
When calorie intake exceeds the body’s energy needs, the excess glucose is converted into glycogen, which is stored in the liver and muscles for future conversion into energy. Weight gain occurs after the body’s capacity for glycogen storage is reached. At this point, glucose from excessive calorie intake is converted into acetyl coenzyme A via a metabolic pathway involving the enzyme ATP-citrate lyase and then into fat molecules, which are stored in fat cells. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. HCA may reduce the synthesis of fatty acids in humans during a persistent excess of energy intake as carbohydrate.
Life Extension Questions & Answers
What are Life Extension's quality control standards?
Life Extension uses only premium quality vitamins and other ingredients. Their dedication to excellence insists that their nutritional supplements meet the highest standards and criteria. This is why Life Extension insists on purchasing only the highest quality raw material from all over the world, primarily from leading US, Japanese and European sources. Life Extension goes one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standards.
Why are Life Extension's nutritional supplements more advanced than other dietary supplements?
The unique ingredients included in Life Extension's products are often years ahead of the products sold by commercial vitamin companies. Life Extension scientists analyze thousands of scientific studies every week to make sure their health-promoting formulas include the most advanced life extending ingredients in the world. The Foundation interacts with the world's foremost gerontology researchers in order to obtain inside information about anti-aging breakthroughs before these findings are published. The Life Extension Foundation funds the most advanced anti-ischemia laboratory in the world, where antioxidant vitamins, hormones, and pharmaceutical agents are used to prevent free radical induced cellular damage.
Are their vitamins natural or synthetic?
Life Extensions carries a combination of natural and synthetic vitamins and supplements. Some advertising statements would have us believe that "natural" is better, but natural supplements in some instances contain impurities such as pollen and naturally occurring hormones the can cause problems for some people. Synthetic nutrients are manufactured to be chemically identical (with the exception of vitamin E) to those extracted from natural sources, and are the most pure nutrient vitamins.
What does Life Extension do to ensure the quality of its products?
They focus on three specific areas:
- Raw Materials: Unlike other supplement companies, the ingredients that go into their supplements are not chosen based on cost. Instead they are chosen based on purity (to ensure contaminants such as microbes and heavy metals comply with regulatory and GMPs requirements), potency, and usage in successful scientific research.
- Validation of the Efficacy of Ingredients by Scientific Research: They use ingredients and dosages that accurately replicate the most successful results obtained in scientific studies for maximum efficacy.
- Manufacturing: Naturally, they are in strict compliance with current Good Manufacturing Practice (GMP) for manufacturing, packaging, and storage.
Does the label accurately list exactly what's in the bottle?
Yes. All active ingredients from patented, scientifically validated raw materials as well as final, finished products are verified using advanced analytical methods such as HPLC (high performance liquid chromatography), MS (mass spectrometry), etc., to ensure each and every product accurately meets label claims in strict compliance with their demanding product specifications.
What are the "Other Ingredients" on the label, and why are they important?
They are inactive ingredients (excipients) that play a number of critical, essential roles in the manufacturing process including:
- Achieving uniform density for accurate dosing
- Dispersing the active ingredients evenly throughout a solid tablet, capsule, and softgel
- Protecting active ingredients from rapid inactivation due to heat and moisture
- Promoting tablet disintegration, as well as capsule and softgel dissolution
- Sustaining the release of active ingredients into the body over time
Why do some companies refer to these excipients as a threat to your health?
Claiming any product is “pure and free of excipients” can be deceptive advertising, too frequently used to draw attention away from inferior active ingredients! The right inactive ingredients used in the right way do important things … like ensuring that a tablet disintegrates in your GI tract rather than just passing through your system without benefit, or keeping a product from breaking down and being susceptible to microbes. Take Life Extension blueberry extract, for example. It contains AuroraBlue wild-harvested, Alaskan blueberries. To retain their nutritional complexity, these berries are freeze-dried and carefully milled for capsule formulation. But being a whole fruit raw material, it tends to want to reconstitute itself with moisture, which would make it a breeding ground for bacteria. So Life Extension uses a drying excipient to keep the milled blueberry material dry, so it can safely deliver its superior nutritional value compared with other, less costly blueberry extracts in most commercial formulations.
All of the excipients Life Extension uses have earned GRAS (“Generally Regarded As Safe”) status … and are used sparingly. In many cases not using them compromises final product quality! Excipients are used in nutritional supplements to ensure uniform density of complex active materials, to achieve even dispersion of active ingredients, and to promote appropriate disintegration and/or dissolution of active ingredients inside your body…to name but a few of the critical roles played by excipients.
Should I be concerned about the use of stearic acid?
Stearic acid functions as a flow agent in the manufacture of quality products, and stearic acid also occurs naturally in the foods you eat. For example, four ounces of dark chocolate contain 3,625 mg of stearic acid; a cup of kidney beans contains 1,655 mg of stearic acid; an ounce of raw ground beef (grass-fed) contains 2,063 mg of stearic acid; and a half pound of lean raw turkey contains 1,642 mg of stearic acid. Even a tablespoon of allspice contains 1,513 mg of stearic acid! Their supplements, on the other hand, typically contain no more than 10 mg per capsule. They always use the lowest level of magnesium stearate possible.
Should I be concerned that products with soybean oil or lecithin are a hidden source of phytoestrogens?
While it is true that soy isoflavones are phytoestrogens, the amount of phytoestrogens in soybean oil or soy lecithin is so minute, the USDA lists in foods as having zero value for isoflavones.
Should I be concerned with the usage of genetically modified plants (GMOs)?
Soybeans are an example of a crop that has used extensive genetic engineering to increase crop yield. The reality is that soybean oil and soy lecithin are highly processed derivatives of soy … far removed from their soy origin. Genetic modification doesn’t alter the entire plant… only a specific gene. Thus, specific molecules like soy lecithin are the same whether they come from a GMO or non-GMO soy source. However, due to their sensitivity to customer concerns, products with corn and soy-based active ingredients are in process of having the labels updated to list when soy and corn-derived active ingredients have been certified to be from non-GM food crops. As the labels are updated the information will be transferred to the product descriptions on their website and directory. Currently Life Extension already offers several premium quality non-GMO soy isoflavone extract products.
Does the gelatin used in softgels and capsules contain MSG?
Gelatin does not contain MSG...but does contain about 0.03 grams of glutamic acid in one softgel. To put this small amount in perspective, a person ingests about 120 times more glutamic acid in a serving of asparagus, cabbage or tomatoes!
What's the difference between tablets, capsules and softgels?
Sophisticated products require sophisticated delivery systems. The best companies choose the most effective finished form based on the characteristics of the raw materials, and the desired disintegration or dissolution characteristics of the finished products and the active ingredients.
Why aren't Life Extension products organic?
The word "organic" conveys the perception of quality to consumers. But it actually related to foods that are grown rather than products that are formulated. Many of their scientifically validated raw materials are not produced organically. Rather, their mandate include rigorous testing and scrupulous processing. The objective is purity...both in terms of their raw materials and their finished products.
About Life Extension
Life Extension was officially incorporated in 1980, but its founder has been involved in anti-aging research since the 1960s. Life Extension is the largest organization dedicated to investigating every method of extending the healthy human life span. When seeking anti-aging therapies, health and nutrition, Life Extension has reported discoveries in the areas of atherosclerosis and stroke prevention, diabetes, prostate health, hormone replacement therapy, and other health concerns. Life Extension is a nonprofit, tax-exempt organization whose goal is to conquer the aging process within the next decade.