Life Extension Optimized Irvingia African Mango (Irvingia Gabonensis) with Phase 3 Calorie Control Complex - 120 Vegetarian Capsules
Life Extension Optimized Irvingia (Irvingia Gabonensis) with Phase 3 Calorie Control Complex with African Mango is a highly studied weight loss dietary supplement. Public health agencies blame gluttonous behavior and lack of physical activity as the sole reasons for today’s obesity epidemic. Ignored are a plethora of age-related metabolic changes that predispose us to weight gain, even when we try to cut back on caloric intake. The good news is that you don’t have to do it alone, Life Extension Optimized Irvingia African Mango can help! Scientists have identified natural compounds, such as Life Extension Optimized Irvingia African Mango that function via multiple mechanisms to combat the underlying factors involved in excess accumulation of body fat.
New Phase 3 sucrase modulator
New green tea phytosome
A recent study in the journal Science concluded that a calorie-restricted diet can delay disease onset and age-related mortality in primates. While Life Extension readers understand the benefits of calorie restriction, that doesn’t make it any easier to cut back on one of the major calorie culprits in the American diet: refined sugar.
Sucrase is an enzyme that breaks down sucrose in the digestive tract for absorption into the bloodstream. Phase 3 is a new, patented compound that functions as a beneficial modulator of sucrase. By delaying the rapid absorption of sucrose, Phase 3 can help support the healthy release of insulin and sugar into the bloodstream in response to sucrose ingestion that readily converts to body fat. Phase 3 contains a natural substance found in plants called L-arabinose that provides an important new weapon in the battle to reduce the number of absorbed calories from sugar.
The effects of green tea polyphenols in inhibiting the breakdown and absorption of dietary fats have been demonstrated in several studies. More recent research confirms the metabolic-enhancing properties of a proprietary green tea phytosome that is absorbed into the bloodstream better than conventional green tea products. A clinical trial documents 30 pounds of weight loss and a 10% reduction in waist circumference in 90 days when 300 mg/day of this new green tea phytosome is taken in conjunction with lifestyle modification. The placebo group that followed the same lifestyle modification program lost only 9.9 pounds and only 5% of their waist size. This new green tea phytosome provides two important components of a comprehensive weight loss program.
Inhibiting the alpha-amylase enzyme
Aging reduces our ability to utilize the carbohydrates (and fats) that constitute what most would consider part of a healthy diet. The result is that as we grow older, our bloodstreams become chronically overloaded with glucose and triglycerides that not only make it difficult to shed fat pounds, but also create vascular problems. A proven method to maintain healthy blood glucose is to neutralize the alpha-amylase enzyme in the intestines.
A natural bean extract (Phaseolus vulgaris) inhibits alpha-amylase. In a human trial in which all overweight participants were placed on a 2,000-2,200-calorie, carbohydrate-rich diet, those taking Phaseolus vulgaris lost 6.5 pounds and 1.2 inches in waist size in only 30 days compared with 0.8 pounds and 0.2 inches in the placebo group. Inhibiting the alpha-glucosidase enzyme
Maintaining healthy blood glucose (and triglyceride) usually requires more than just inhibiting the alpha-amylase enzyme. Another intestinal enzyme that enables carbohydrate absorption is alpha-glucosidase. A patented seaweed extract (InSea2) has demonstrated potent inhibiting effects against alpha-glucosidase and alpha-amylase. When given to laboratory animals, this seaweed extract, as observed in overweight and obese individuals, can preclude fat loss. Excess glucose converts to triglycerides, which is the primary form that fat is stored in the body. By consuming compounds that inhibit the glucosidase and amylase enzymes before meals, the rate of carbohydrate absorption can be significantly slowed, resulting in reduced conversion of glucose to stored body fat.
Remember, young healthy individuals rapidly convert ingested fats-sugars into energy. Age-related changes reduce our metabolic capacity to efficiently utilize dietary sugars and fats, ergo the importance of impeding their absorption to help maintain a healthy body weight in maturing individuals.Restoring leptin sensitivity
Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough. Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis. Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds. An extract from a West African food called Irvingia gabonensis has been shown to restore leptin sensitivity by suppressing inflammatory factors. In a recently published study, Irvingia demonstrated a marked reduction in leptin blood levels, a reduction in appetite, followed by significant loss of body weight and inches off the waistline. In addition to restoring leptin sensitivity, Irvingia has demonstrated the following fat-reducing mechanisms:
The New Optimized Irvingia with Phase 3 Calorie Control Complex
- Glycerol-3-phosphate dehydrogenase is the enzyme that converts blood glucose to triglycerides in fat cells. Irvingia has the unique effect of inhibiting glycerol-3-phosphate dehydrogenase, thus reducing the amount of blood glucose that converts to stored body fat.
- Irvingia has alpha-amylase-inhibiting properties (like InSea2 and Phaseolus vulgaris), thus slowing the rate of carbohydrate absorption from the intestines.
- Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells. Heavy individuals have low adiponectin blood levels, which contribute to the phenomenon of insulin resistance. Irvingia has been shown to significantly increase adiponectin blood levels.
In reviewing the remarkable effects demonstrated by these natural compounds, one might think that any one of them might be a solution to one’s weight problem. The reality is that aging individuals often have many obesity factors that can sabotage the best weight-loss programs.
The Optimized Irvingia formula provides a combination of nutrients that combat age-related fat accumulation via the following seven distinct mechanisms:
Life Extension Frequently Asked Questions
- Enhancing resting energy expenditure at the cellular level.
- Impeding dietary fat absorption from the intestines.
- Inhibiting alpha-amylase to slow intestinal carbohydrate absorption.
- Inhibiting alpha-glucosidase to further slow intestinal carbohydrate absorption.
- Enhancing leptin sensitivity to reduce hunger and stimulate adipocyte lipolysis.
- Elevating adiponectin blood levels to help restore insulin sensitivity.
- Suppressing glycerol-3-phosphate dehydrogenase to reduce the amount of blood glucose that is converted to stored fat (triglyceride) in the cells.
What are Life Extension's quality control standards?
Life Extension uses only premium quality vitamins and other ingredients. Their dedication to excellence insists that their nutritional supplements meet the highest standards and criteria.
That is why Life Extension insists on purchasing only the highest quality raw materials from all over the world, primarily from leading US, Japanese and European sources. Life Extension goes one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standards.
Why are Life Extension's nutritional supplements more advanced than other dietary supplements?
The unique ingredients included in Life Extension's products are often years ahead of the products sold by commercial vitamin companies. Life Extension scientists analyze thousands of scientific studies every week to make sure their health-promoting formulas include the most advanced life extending ingredients in the world. The Foundation interacts with the world's foremost gerontology researchers in order to obtain inside information about antiaging breakthroughs before these findings are published. The Life Extension Foundation funds the most advanced anti-ischemia laboratory in the world, where antioxidant vitamins, hormones, and pharmaceutical agents are used to prevent free radical induced cellular damage.
Are Life Extension's vitamins natural or synthetic?
Life Extension carries a combination of natural and synthetic vitamins and supplements. Some advertising statements would have them believe that "natural" is better, but natural supplements in some instances contain impurities such as pollen and naturally occurring hormones that can cause problems for some people. Synthetic nutrients are manufactured to be chemically identical (with the exception of vitamin E) to those extracted from natural sources, and are the most pure nutrient vitamins.
What does Life Extension do to ensure the quality of its products?
They focus on three specific areas.
- Raw Materials: Unlike other supplement companies, the natural ingredients that go into Life Extension's supplements are not chosen based on cost. Instead they are chosen based on purity (to exclude contaminants such as microbes and heavy metals), potency, and usage in successful scientific research.
- Validation of the Efficacy of Ingredients by Scientific Research: Life Extension uses ingredients and dosages that accurately replicate the most successful results obtained in scientific studies for maximum efficacy.
- Manufacturing: Naturally, Life Extension is in strict compliance with current Good Manufacturing Practice (GMP) for manufacturing, packaging, and storage.
Does the label accurately list exactly what’s in the bottle?
Yes. All active ingredients from patented, scientifically validated raw materials as well as final, finished products are verified using advanced analytical methods such as HPLC (highperformance liquid chromatography), MS (mass spectrometry), etc., to ensure each and every product accurately meets label claims in strict compliance with their demanding product specifications.
When it comes to supplements, is cost an indicator of quality?
Where Life Extension is concerned, yes. Patented materials validated in scientific studies cost more — period. In contrast with many commercial brands focused on driving up margins by using the cheapest raw materials available, Life Extension collaborates with raw material suppliers who invest in scientific validation of their ingredients, which increases material costs. With Life Extension products, you get the quality you pay for.
What are the “Other Ingredients” on the label, and why are they important?
They are inactive ingredients (excipients) that play a number of critical, essential roles in the manufacturing process including:
- Achieving uniform density for accurate dosing
- Dispersing the active ingredients evenly throughout a solid tablet, capsule, and softgel
- Protecting active ingredients from rapid inactivation due to heat and moisture
- Promoting tablet disintegration, as well as capsule and softgel dissolution
- Sustaining the release of active ingredients into the body over time
Why do some companies refer to these excipients as a threat to your health?
Claiming any product is “pure and free of excipients” can be deceptive advertising, too frequently used to draw attention away from inferior active ingredients! The right inactive ingredients used in the right way do important things … like ensuring that a tablet disintegrates in your GI tract rather than just passing through your system without benefit, or keeping a product from breaking down and being susceptible to microbes. Take Life Extension blueberry extract, for example. It contains AuroraBlue wild-harvested, Alaskan blueberries. To retain their nutritional complexity, these berries are freeze-dried and carefully milled for capsule formulation. But being a whole fruit raw material, it tends to want to reconstitute itself with moisture, which would make it a breeding ground for bacteria. So Life Extension uses a drying excipient to keep the milled blueberry material dry, so it can safely deliver its superior nutritional value compared with other, less costly blueberry extracts in most commercial formulations.
All of the excipients Life Extension uses have earned GRAS (“Generally Regarded As Safe”) status. In many cases not using them compromises final product quality! Excipients are used in nutritional supplements to ensure uniform density of complex active materials, to achieve even dispersion of active ingredients, and to promote appropriate disintegration and/or dissolution of active ingredients inside your body.
Should I be concerned about the use of stearic acid?
Stearic acid functions as a flow agent in the manufacture of quality products, and stearic acid also occurs naturally in the foods you eat. For example, four ounces of dark chocolate contain 3,625 mg of stearic acid; a cup of kidney beans contains 1,655 mg of stearic acid; an ounce of raw ground beef (grass-fed) contains 2,063 mg of stearic acid; and a half pound of lean raw turkey contains 1,642 mg of stearic acid. Even a tablespoon of allspice contains 1,513 mg of stearic acid! Life Extension supplements, on the other hand, typically contain no more than 10 mg per capsule. They always use the lowest level of magnesium stearate possible.
Should I be concerned that products with soybean oil or lecithin are a source of phytoestrogens?
While it is true that soy isoflavones are phytoestrogens, the amount in soybean oil or lecithin is so minute, the USDA lists it in foods as having zero value for isoflavones. To give you a frame of reference, Life Extension’s Ultra Natural Prostate contains 4 mg of lecithin which supplies only about 0.006 mg of soy isoflavones!
Should I be concerned with the usage of genetically modified plants (GMOs)?
Soybeans are an example of a crop that has used extensive genetic engineering to increase crop yield. The reality is that soybean oil and soy lecithin are highly processed derivatives of soy, far removed from their soy origin. Genetic modification doesn’t alter the entire plant, only a specific gene. Thus, specific molecules like soy lecithin are the same whether they come from a GMO or non-GMO soy source. However, due to their sensitivity to customer concerns, products with corn and soy-based active ingredients are in process of having the labels updated to list when soy and corn-derived active ingredients have been certified to be from non-GM food crops.
Does the gelatin used in softgels and capsules contain MSG?
Gelatin does not contain MSG, but does contain about 0.05 grams of glutamic acid in one softgel. You ingest about 120 times more glutamic acid in a serving of asparagus, cabbage or tomatoes!
What’s the difference between tablets, capsules and softgels?
Sophisticated products require sophisticated delivery systems. The best companies choose the most effective finished form based on the characteristics of the raw materials, and the desired disintegration or dissolution characteristics of the finished product and the active ingredients.
Why aren’t Life Extension products organic?
The word “organic” conveys the perception of quality to consumers. But it actually relates to foods that are grown rather than products that are formulated. Many of their scientifically validated raw materials are not produced organically. Rather, their mandate includes rigorous testing and scrupulous processing. The objective is purity, both in terms of our raw materials and their finished products.