Biotivia Bio Span+ Longevity Trans-Resveratrol Bio Enhanced 500 mg. - 60 Vegetarian Capsules
Biotivia Bio Span+ Bio Enhanced is the supreme resveratrol longevity supplement. Bio Span+ is the only scientifically formulated resveratrol-based supplement which provides a truly synergistic blend of longevity compounds in one capsule. Bio Span+ contains a full array of SirT-1 activators, telomerase precursors, and neurotropic agents, the three major anti-aging bioceuticals. The objective of their scientists was to create a totally natural product which attacks aging at the metabolic, epigenetic, and neural levels. This translates into slower physical, cellular and mental aging.
Bio Span+ is the most economical way to obtain the longevity-enhancement benefits of bio-enhanced Resveratrol, Silymarin, Curcumin and the two rare astragalosides of Astragalus in one convenient capsule. With Bio Span+ you can be assured you will receive Biotivia quality and potency.
- Bio Span+ is the only scientifically formulated resveratrol-based supplement which provides a truly synergist blend of longevity compounds in one capsule.
- Bio Span+ contains SirT-1 activators, telomerase enhancers, and neurotropic agents, the three major life span related bioceuticals.
- Bio Span + contains more of the telemerase enhancing compound than a well known competing product that sells for over $400 per bottle.
- The objective of their scientists was to create a totally natural product which attacks aging at the cellular, epigenetic, mitochondrial and telemere sites.
- This translates into slower physical, cellular, and neurological aging. It also translates into a higher level of energy, improved concentration and mood, and improved general health, as well as a much lower risk of contracting the usual serious medical conditions associated with the aging process.
- Each of the ingredients contained in Bio Span+ have been found to support increased health and longevity in published, peer-reviewed clinical studies.
- Packed in advanced all vegetable Pfizer V Licaps – which, unlike traditional gelatin capsules, keep out oxygen, light and other contaminants that destroy the potency of fish oil products -- often while they are still on the shelves.
- Suitable for vegetarians, vegans, and all faiths.
Why Bio Span+ is Unique
The Trans-Resveratrol contained in Bio Span + is a 50/50 blend of the same bio-enhanced proprietary full-spectrum found in Bioforte and the pure Trans-resveratrol they put in Transmax. This provides all of the important glucosides of the Polygonum Cuspidatum plant, including Polydatin and an extra helping of the pure Trans-Resveratrol isomer.
They combine the Resveratrol with concentrated extract of Curcumin, a compound shown to stimulate the growth of new neurons, as well as Silymarin, an extract of the Blessed Milk Thistle plant that, like Trans-Resveratrol, is a SirT-1 activator, and the two Astragalosides which researchers have found to have telomerase stimulation properties. One other company is selling a therapy based upon Astragalosides IV, one of the compounds in Bio Span+, for around $25,000 for a one year program of supplementation and telomere length testing.
Bio Span+ Supreme Longevity Supplement Ingredients
Regenerate, Rejuvenate and Restore
Trans-Resveratrol 75%, 200mg* -- This ingredient alone would make an extraordinary product. Bio-enhanced natural Resveratrolmodulates the benefits of the other polyphenols contained in this complex and activates the SirT longevity genes.
Silymarin 200mg* -- A second SirT gene activator that complements Trans-Resveratrol. Extracted from blessed milk thistle, Silymarin supports healthy liver function and modulates blood glucose levels. Chosen over Quercetin, which actually suppresses SirT activation and interferes with the important Resveratrol metabolites.
Astragalus 300mg* -- Considered to be the most promising longevity compound after Resveratrol. Some studies indicate that this extract may have telomere protective properties. Also supports immune system, and may increase the body's resistance to common viruses. Bio Span+ contains the two essential Astragalosides of this compound including the rare Astragaloside IV molecule.
Curcumin 300mg* -- A uniquely effective polyphenol that acts as a free radical scavenger and antioxidant, inhibiting lipid peroxidation and oxidative DNA damage. Curcumin's beneficial properties are well established and supported by a wealth of peer-reviewed published data. Standardized to minimum 96% active curcumins.
* Per serving of 2 Vcaps.
Frequent Questions Relating to Bio Span Longevity Supplement
Why Bio Span Trans-Resveratrol Longevity?
Although resveratrol is the most publicized new longevity compound, it alone will not address your entire need for advanced nutrition; hence Bio Span+ was developed.
Bio Span+ was designed to complement the life extension properties of resveratrol by adding concentrated polyphenols and the Sirt 1 Activator silymarin, along with curcumin, and the two critical astragalosides of Astralagus which are believed by many scientists to have telomere protective properties. No other product currently being manufactured compares to Bio Span+ in its potential for enhancement of longevity.
Why did Biotivia Choose Not to Include Quercetin?
They have devoted quite a bit of study and research to quercetin's effect on resveratrol and resveratrol's metabolites and the issue of Sirt 1 activation. Their conclusion is that the most recent and best designed studies, including a study by one company that actually puts quercetin in their product, conclude that quercetin strongly inhibits the metabolites of resveratrol and suppresses SirT1 activation. Quercetin has been shown in numerous studies to interfere with the beneficial metabolites of resveratrol. These metabolites, particularly resveratrol glucuronide, resveratrol sulphate and picead possess important health properties. Studies also confirm that enterohepatic recirculation (recirculation by the liver) of these metabolites contributes significantly to the enhanced exposure of resveratrol in the tissues of mammals. Furthermore, quercetin's undesirable Sirt 1 suppression clearly rules it out as an ingredient in any longevity product.
If Biotivia scientists believed that quercetin would improve their products in a substantive way it would be in their interest to add it to their products. From an economic standpoint this would also benefit us, as quercetin is far less costly than the high-grade resveratrol they use in their supplements. A recent study by the makers of Longevinex strongly confirms their conclusion that quercetin inhibits SirT1 and possibly the other sirtuins as well. In this study a combination of resveratrol and quercetin along with the filler oat bran actually reduced SirT1 activation by a factor of 1.7 times; precisely the opposite effect one is looking for in a product designed to increase longevity.
How Should I Store the Products?
Their products are very stable at room temperature but it will not hurt to refrigerate them. Either way they will last for at least 2 years on the shelf after opening.
How Many Capsules Should I Take?
Bio Span dosage is a very individual choice and depends on your weight, metabolism, individual body chemistry and your primary reasons for taking the product. In general the amount you take should be in proportion to your weight. For example a 200 pound man should take roughly twice as much as a 100 pound woman, all other things being the same. If you are taking the product for a pre-existing condition then the dosage would be significantly higher than if you were taking resveratrol as part of a preventative regimen. As part of a daily preventative regimen the average adult (i.e. 150 lbs.) should take 2 Bioforte or 1 Transmax per day. This equates to about $1 per day for a supplement which has an extraordinarily wide range of benefits. If, however, you are treating a pre-existing condition many specialists would recommend a much higher dosage, say at least 4 times the preventative dose, or 4 Transmax a day.
When and How Should I Take the Product?
Resveratrol is not very water soluble therefore your body needs to produce enzymes such as bile from the liver and gall bladder to assimilate it. Therefore they recommend that you take their products along with or shortly after taking small amounts of an oily food. This stimulates the production of the necessary enzymes and facilitates absorption. Since their products are natural they can be taken on an empty stomach and will be absorbed more easily if taken at least one hour before or after consuming a substantial meal. Their products may be taken at any time however early morning is when your body best absorbs most nutrients. To prevent intracellular oxidation of the resveratrol, and this applies to many other polyphenols as well, one should take an antioxidant with one's daily resveratrol dose. Although something as simple as one gram of Vitamin C will help prevent oxidation they naturally recommend that you consider Biotivia's super fruit extract formulation, Bio Quench, as your choice of antioxidant. Bio Quench tested at an ORAC rating per gram of over 13,500. This is the highest rating for any dry compound ever tested by Brunswick Laboratories, the inventor of the ORAC test.
Why choose Biotivia?
- With over 20 years of experience processing critical botanicals for the medical and functional food industries, Biotivia designs, formulates and manufactures unique natural herbal supplements which are backed by science and are the most efficacious available in their categories.
- They have a staff of scientists, pharmacists, and physicians at the core of their company.
- They offer high potency, HPLC tested, standardized extracts whose actions and modalities are based on peer-reviewed studies and the knowledge they have gained via collaborations with many of the world’s top universities and medical schools.
- Purity is an obsession with Biotivia and higher purity equals higher potency and fewer side effects. They use the highest quality bio-active extracts and as a result their products are typically higher strength than ordinary supplements and therefore produce effects that you can actually feel.
- They select ingredients for their formulations which have been shown to complement each other's properties.
Each individual product is designed to address specific biological processes and to modulate cellular and genetic pathways known to improve health and wellness.
- Biotivia Resveratrol Product are the overwhelming first choice of the scientific and medical communities doing human clinical trials in the US, Europe, Asia and Australia.
More reasons to choose Biotivia
- They created the world’s original high-potency Resveratrol supplements. They are the Resveratrol specialists and use Trans-Resveratrol (the active form of Resveratrol) in most of their formulations because of its unique and astonishing range of benefits.
- They are the only company to have two Trans-Resveratrol products approved by an internationally recognized and respected independent testing lab. Transmax was the most potent product tested and Bioforte was rated the best value. There is no substitute for truly independent product evaluation.
- Their products are all natural, most are vegan and contain no animal products, preservatives, GMO's or fillers of any kind. No Sirt deactivators such as quercetin are used in any Biotivia supplements. Their capsules are all vegetable Pfizer Vcaps.
- Transmax, their 500mg pure Trans-Resveratrol product, is being used by prestigious universities and hospitals such as Albert Einstein Medical College, UC Davis and Ottawa Hospital for human clinical trials. Their Resveratrol is being used in more human trials than all other brands combined.
- Their products are highly bio-available and effective, as their scientific team understands that real benefits are only achieved when cellular concentrations are reached and maintained. The superior bio-availability of Biotivia Resveratrol has been validated by experts at the National Advertising Division of the US national BBB.
- They manufacturers their own products which are made in accordance with FDA GMP and USP standards in their own facility. They do not buy raw materials from brokers or re-sellers and simply fill capsules.
- Their product is being considered as an IND by the National Institute of Health. No other supplement has met the rigid quality control and purity criteria necessary for this certification.
- They pack their product in nitrogen to maintain its potency and insure at least a 24 month shelf life. They are also the only manufacturer or supplier to utilize a patented active packaging system and oxygen absorbing sachet in the bottle to absorb the free oxygen every time the bottle is opened. This prevents Resveratrol oxidation and preserves potency and bio-activity.
- Many of their customers are Doctors and Healthcare Professionals.
- The bottom line is "Their products work and you will feel the difference in your daily quality of life." Expect more energy, better overall health, clearer mental focus and concentration, better sleep and slower aging.
Biotivia is now part of the AVA family of fine certified products
Biotivia is pleased to announce that the American Vegetarian Association (AVA) has certified Transmax, Bioforte, BioQuench, BioShape, BioSpan, Acai + and Immune Edge+ as Vegan approved supplements.
This is a great achievement as the AVA have tough guidelines and procedures to follow and this is testament that Biotivia go 'above and beyond' to cater for all our customers.
To be awarded this prestigious stamp of approval can give all our vegetarian and Hindu customers extra reassurance that Biotivia is the Number one Vegan supplement company.
About Biotivia Longevity Bioceuticals
Biotivia is fueled by its relentless devotion to vitality, health and wellbeing. Our guiding principle is to develop botanical products that are safe, free of adverse side effects, and uniquely potent and efficacious, that contribute to a significant improvement in a person's quality of life.
In order for Biotivia to make a product there must exist a preponderance of definitive scientific evidence which demonstrates that a natural compound or combination of compounds has important and even necessary health benefits. Our formulas will always be based upon intensive research and collaboration with the scientific and academic communities.
Biotivia Longevity Bioceuticals, LLC is a leading formulator and manufacturer of high potency bioceutical supplements and DNA cosmetic rejuvenation products for the medical, consumer and functional food markets. The company offers products designed to address specific biological processes and to modulate cellular and genetic pathways known to improve health and foster vitality from both the inside out.
James Betz, PhD, Cell Biologist is the Managing Director, and along with his premier team of international longevity research and development scientists have focused on a polyphenolic compound called Resveratrol, demonstrating astonishing DNA repair and anti-aging properties. Biotivia created the first high-potency Resveratrol supplement.
High potency, HPLC tested, standardized extracts are developed into sophisticated supplement formulations with actions and modalities based on peer-reviewed studies. Biotivia products are manufactured in their own facility in accordance with FDA, GMP and USP standards. A patented active packaging system is used for supplement products in order to maintain, bio-activity, potency and insure extended shelf life. Advanced, all-vegetable Pfizer V Licaps are used for encapsulated products in order to prevent oxidation and contamination.
Founded in 1992, Biotivia was originally established in Vienna Austria as a supplier of natural raw materials and botanicals to the supplement and functional food industries and to researchers and scientific institutions worldwide. Biotivia maintains US headquarters in New York and offices in Kansas City, Kansas, Verona, Italy, London and Singapore.
The company has their own in-house scientists, pharmacist, and researchers dedicated to the foremost anti-aging discoveries. Additionally, they collaborate with scientists and universities worldwide on human clinical trials to prove the efficacy of their products. In-house scientists include:
James Betz, Ph.D Cell Biology
Saurabh Shah, Ph.D Biology and Medical Research
Payal Shah, Ph.D Pharmacist
Philip Akers, Chemical Engineering and MBA
Serge Boileau, Ph.Ds Chemistry and Biology and Professor of Biochemistry for 35 years
Abbas Green, MD and PhD, specializing in Endocrinology
Gloria Sabater, Ph.D Pharmacist
Wolf-Dieter Rhewoods Ph. D Professor in Biochemistry