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Doctor's Best - Best Vitamin D3 1000 IU - 180 Softgels

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    Doctor's Best - Best Vitamin D3 1000 IU - 180 Softgels

    • Code#:80336
    • Manufacturer:Doctor's Best
    • Size/Form:180  Softgels
    • Packaged Ship Weight:0.10
    • Servings:180
    • Dosage Size:1  Softgel(s)

    Doctors Best - Best Vitamin D3 1000 IU 180 Softgel Capsules

    Doctors Best Vitamin D3 (cholecalciferol) is a nutrient that is critical to many bodily functions. Doctor's Best Best Vitamin D3 is beneficial for supporting bone health, immune wellness, cardio- vascular function, and cellular metabolism, among others.  Mounting research is highlighting the ever-increasing benefits of optimal vitamin D3 status. Vitamin D3 is known to interact with over 200 different genes and thus plays a crucial regulatory role as a metabolic activator for a multitude of metabolic processes.

    • Science-based nutrition
    • Dietary supplement

    Vitamin D from dietary intake or sun exposure requires two activation steps in the body. The first activation occurs in the liver, while the second activation occurs in the kidneys, allowing for regulation of calcium metabolism. However, vitamin D receptors are present throughout the body, in tissue such as the skin, cartilage, heart, prostate, bones and intestines. Thus, the second activation step also takes place in local tissues. Recent discoveries have highlighted the important modulatory effects of vitamin D on various cells of the immune system.

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    Vitamin D enhances and regulates immune function
    Studies show that vitamin D has important immunomodulatory effects. It is known that various cells of the immune system, such as T lymphocytes and antigen presenting cells, express the vitamin D receptor on their surface when activated. Recently, it has been found that treatment of these immune cells with vitamin D influences their expression of cytokines, which are chemical messengers of the immune system. The immune modulating effects of vitamin D extend to monocytes and dendritic cells of the immune system as well. Dendritic cells are important antigen-processing cells of the immune system that function to initiate the immune response. By altering the cytokine expression of dendritic cells, vitamin D may prevent overactivity of the immune response and keep the immune system in a normal healthy state of vigilance.

    Vitamin D supports optimal cardiovascular function
    Research has uncovered the role vitamin D plays in supporting cardiac function. Heart myocytes (cells) express the vitamin D receptor, as do smooth muscle cells of blood vessels. The benefits of vitamin D on the heart are potentially far-reaching. Studies on mice heart cells have shown that vitamin D administration impacts their growth and proliferation. In these cells, vitamin D inhibited the release of a protein that could be detrimental to the function of these cells, displaying cardioprotective properties. It has also been shown that vitamin D has a modulatory effect on heart rhythm. Again, in mouse heart cells, knocking out the effects of the vitamin D receptors led to an increased rate of contraction and relaxation. In normal mouse cardiac myocytes, administration of vitamin D led to normalization of heart contractility. Further studies in mice have led researchers to conclude that vitamin D supports the overall structure and function of the heart in terms of shape, size and performance.

    Studies in humans have confirmed the importance of vitamin D for heart function. In a study consisting of 1,739 participants from the Framingham Offspring Study, those individuals with the highest levels of vitamin D had superior cardiac function in relation to those with low vitamin D levels. These results make sense when taken in context of the overall effects of low vitamin D. These effects include an imbalance in the immune production of inflammatory markers, disturbing the normal inflammatory response and leading to potential effects on all tissues, including the heart and blood vessels. Restoration of optimal vitamin D status supports a healthy, normal inflammatory response and may thus restore the optimal health of the heart and cardiovascular system.

    Furthermore, recent research highlights the profound benefits of vitamin D sufficiency in the realm of markers of cardiovascular wellness. Studies have previously shown that vitamin D supplementation has no effect on weight loss. However a recent study conducted in 200 healthy overweight individuals has shown that vitamin D supplementation can enhance the cardiovascular benefits associated with weight loss. The individuals participating in a 12-month weight reduction program were divided into two groups – one received placebo while the other group received supplemental vitamin D on a daily basis. At the end of the study, it was found that neither placebo nor vitamin D had a measurable effect on weight loss, as both groups lost similar amounts of weight. However, cardiovascular markers and blood lipid markers significantly improved in the vitamin D group, indicating enhanced cardiovascular support with vitamin D supplementation.

    A further way in which vitamin D may influence the health of the cardiovascular system is through its potential blood pressure regulatory effect. While the mechanism of vitamin D’s effect on blood pressure regulation is unclear, it is known that vitamin D regulates calcium balance, supports endothelial function, activates gene transcription, and influences the sodium-potassium balance and aldosterone system in the kidneys. It is likely that vitamin D exerts its blood pressure regulatory effect in one or more of these ways. A study was conducted to assess the effects of vitamin D status on blood pressure. In this study, data from the Third US National Health and Nutrition Examination Survey was used to determine the association of blood pressure levels with vitamin D status in healthy individuals. The results of this study, which included data from 12,644 people, showed that those individuals with the highest vitamin D status had an increased ability to maintain their blood pressure levels in the normal range. By supporting blood pressure levels within a range that is already normal, vitamin D promotes the health and wellness of the cardiovascular system.

    Vitamin D supports healthy bone density and structure
    The role of vitamin D for bone health (alongside that of calcium) has been well-characterized in published literature. Vitamin D is obviously required for optimal calcium absorption. Recent studies have shown that possibly a majority of women with bone health issues have low levels of vitamin D. In some studies, this number is well over 60%. One such study found that out of a total of 2,606 postmenopausal women assessed, more than 64% had levels of vitamin D of less than 30 ng/mL (measured as serum levels of 25(OH) D, a common blood measure of vitamin D sufficiency). These authors state that, according to a recent review article, the optimal vitamin D levels as measured by 25(OH) D are between 50 and 80 ng/mL. Thus, levels near 30 ng/mL are significantly below those considered optimal.

    An interesting study was performed recently in Finland in which 212 adolescent females were divided into three groups – a placebo group receiving no vitamin D, a low-dose vitamin D group (200 IU per day) and a higher dose vitamin D group (400 IU per day). The study aimed to measure the effects of vitamin D intake on bone mineral density in these young healthy females who also had adequate calcium status. At the end of the one year study, both vitamin D groups had significant improvements in bone density measured at the femur bone, whereas the 400 IU group also had significantly higher mineral density at the lumbar spine. These findings indicate the importance of vitamin D in bone structure and formation and also indicate the role of vitamin D in bone health independent of calcium intake.

    Vitamin D promotes healthy aging by enhancing cellular function
    Given its role as a promoter of gene expression, vitamin D affects numerous systems throughout the body. Research unmistakably shows that vitamin D is also a regulator of cellular health and wellness. Aged, unhealthy cells tend to lose their ability to differentiate and perform their original intended function due to the cumulative effects of oxidative damage. Vitamin D, acting as a pro-hormone, promotes the ability of cells to maintain their normal life cycle of birth, differentiation, functional performance and death, when they have become overly damaged. Damaged cells can lead to damaged tissue function. By promoting the normal cell cycle, vitamin D ensures the progression of cells through their functionality and their healthy renewal.

    Suggested Use

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    Take one or two capsules daily or as directed by a knowledgeable physician.


    Doctor's Best - Best Vitamin D3 1000 IU - 180 Softgels
    Supplement Facts
    Serving Size: 1 Capsule
    Servings Per Container: 180 Servings
    Amount Per Serving %DV
    Vitamin D3 1000 IU 250%
    *Daily Value Not Established.
    †Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
    Other Ingredients: Extra virgin olive oil, softgel capsule (gelatin, vegetable glycerin,  purified water).
    The vitamin D3 contained in this product is derived from lanolin, a component of sheep's wool.

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    Recommendation

    100%3 out of 3 reviewers would recommend this product to a friend.
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    By BIN (Flushing , NY )

    good

    I RECOMMEND THIS PRODUCT!
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    By irene (Pomona , CA )

    very good product, good price.

    I RECOMMEND THIS PRODUCT!
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    Manufacturer Info

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    197 Avenida La Pata
    San Clemente, CA,
    Phone: 949-498-3628 Fax: 949-498-3952 Visit website

    About Doctor's Best

    Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

    *The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

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