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Doctor's Best - Best 5-HTP 100 mg. - 60 Vegetarian Capsules

Helps Maintain Mental and Emotional Well-Being!

Item #: 71623
MSRP: $17.99$9.85  you save 45% Per Serving: $0.16
Serving Size: 1 Capsule(s)
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Doctor's Best - Best 5-HTP 100 mg. - 60 Vegetarian Capsules

  • Code#:71623
  • Manufacturer:Doctor's Best
  • Size/Form:60  Vegetarian Capsules
  • Packaged Ship Weight:1
  • Servings:60
  • Dosage Size:1  Capsule(s)

Doctor's Best - Best 5-HTP 100 mg. - 60 Vegetarian Capsules

Doctors Best 5-HTP (5-hydroxy L-tryptophan) is a naturally occurring metabolite of the amino acid tryptophan. 5-HTP is converted in the brain to serotonin, a neurotransmitter substance found at the junctions (synapses) between neurons.Dr 5-HTP helps maintain mental and emotional well-being and promotes healthy sleep. Best 5-HTP is extracted from the seeds of the Griffonia simplicifolia plant.5-hydroxytryptophan (5-HTP) is a naturally occurring metabolite of the essential amino acid tryptophan. The 5-HTP in dietary supplements is derived from the seeds of the African plant Griffonia simplicifolia. Doctor's Best 5-HTP is suitable for vegetarians.

Doctor's Best 5-HTP Benefits:

  • Science-Based Nutrition
  • Dietary Supplement
  • Helps maintain mental and emotional well-being

5-HTP functions as the precursor for serotonin, a monoamine neurotransmitter found in the central nervous system (CNS) and some cells of the digestive tract. In the body, 5-HTP is formed by the addition of a hydroxyl group (–OH) to tryptophan, a reaction catalyzed by the enzyme tryptophan hydroxylase. This enzyme can be hindered by stress and conditions such as vitamin B deficiency, which is one reason B is included in this formula. Additionally, pyridoxal phosphate (vitamin B) is necessary for 5-HTP to be converted to serotonin. Vitamin C participates in the conversion of tryptophan to 5-HTP and of tyrosine to norepinephrine, another important neurotransmitter.

Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors in the CNS. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including the nutritional status of the individual and the competition between tryptophan and other amino acids for transport across the blood-brain barrier. Whereas tryptophan may be sidetracked into the production of niacin or protein, 5-HTP readily crosses the blood-brain barrier and becomes available for serotonin synthesis. Therefore, supplementation with 5-HTP is a more direct route to serotonin production.

In contrast to tryptophan, orally consumed 5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract, with up to 0% then appearing in the bloodstream. The implications of possibly altering serotonin in this manner are significant: serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.

Enhances sense of well-being
A synaptic serotonin deficit is hypothesized to be capable of a major adverse effect on mood. Supplementation with 5-HTP therefore is believed to balance mood via an increase in serotonin synthesis. This was researched extensively upon discovery that 5-HTP could be used to alter serotonin levels in rats. In a pilot study on humans, the subjects receiving 5-HTP showed a 35% increase on a mood rating scale, whereas the placebo group showed a 6% decrease.

A comprehensive review of seven open and seven controlled clinical studies found that oral consumption of 5-HTP improved mental and emotional status in 60 to 70 percent of subjects. The results varied from "modest" to "marked."  Dosages ranged from 50 to 300 mg daily.
 
In a study of 134 recently bereaved men, mood was assessed using the Profile of Mood States (POMS) questionnaire. Men in this study who had adequate pyridoxine (vitamin B6) status had significantly better total mood disturbance (TMD) and confusion-bewilderment subscale scores. Additionally, pyridoxine deficiency was specifically related to a fatigued mood.

Promotes calming down and relaxing
In a study of  healthy adults, half of the subjects were given 00 mg of 5-HTP, and the other half given placebo. All of the subjects were then given a stress-inducing substance (CCK-) to provoke tension and elicit nervous irritability. In the female subjects who took the 5-HTP, there was a significant reduction in the rate and intensity of the negative cognitive reaction. This research built on previous studies where administration of 5-HTP produced a calming effect in subjects prone to nervous irritability.

Promotes satiety and supports healthy eating patterns

May promote weight loss as part of a weight loss plan
An exciting area of research recently regaining attention is the relationship between serotonin and appetite—and therefore its potential to aid in the maintenance of a healthy weight. While serotonin is renown for its function in the brain, 5% of serotonin is actually found in the gastrointestinal tract. Accordingly, serotonin is deeply involved in gut physiology, including visceral perception and weight maintenance. In research where 5-HTP was administered at higher doses, it was discovered that these high doses of 5-HTP produced weight loss in subjects, mainly through its influence on satiety and an altered appetite for specific macronutrients.

A study that orally administered either 5-HTP or placebo to  women for 5 weeks (without any dietary restrictions) resulted in significantly decreased food intake and weight loss in the women taking 5-HTP, compared to placebo. In a double-blind, randomized study, 0 subjects received either 5-HTP capsules or placebo for  weeks with dietary restrictions, and then for  weeks without dietary restrictions. During both periods (with or without dietary restrictions), the 5-HTP subjects experienced early satiety, a reduction in carbohydrate intake, and significant weight loss compared to placebo.0 In a subsequent double-blind, randomized study,  subjects received placebo and  subjects received 5-HTP capsules for  weeks. The 5-HTP group experienced weight loss through a significant decrease in carbohydrate and fat intake.

An animal study took experimental use of 5-HTP a step further by investigating food deprivation and also stress-induced eating. Although the 5-HTP was injected rather than orally administered in the rats, results clearly showed that administration of 5-HTP suppressed eating compared to placebo treatment in food-deprived rats and even more so in rats undergoing stress.

May improve quality of sleep
Studies have shown that 5-HTP influences the quality of sleep by increasing REM (rapid eye movement) sleep. Administration of as little as 00 mg of 5-HTP in the evening prior to bedtime has been shown to increase the duration of REM sleep from 5 to 5% and decrease the amount of non-REM sleep.

Potent scavenger of free radicals
Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from their hydroxyl groups (–OH), which donate electrons to oxidants. 5-HTP is formed from tryptophan by the addition of an –OH group, which gives 5-HTP its antioxidant properties. This is in contrast to tryptophan, which is sensitive to oxidation. The effectiveness of 5-HTP in preventing lipid and protein oxidation is believed to contribute to liver cell integrity by countering membrane rigidity. A recent laboratory test demonstrated that 5-HTP is a more effective hydroxyl radical scavenger than even vitamin C.

Suggested Use

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As a dietary supplement, take 1 capsule two to three times daily, with or without food.

Not to be used when taking MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), or other anti-depressant medications. It should also not be used by individuals taking any of the category of medications known as "triptans."

Keep out of reach of children.


Doctor's Best - Best 5-HTP 100 mg. - 60 Vegetarian Capsules
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60 Servings
Amount Per Serving %DV*
5-hydroxy L-tryptophan 100 mg *
*Daily Value Not Established.
†Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
Other Ingredients: Modified cellulose (veggie cap), rice powder, magnesium stearate (vegetable source)

Average Rating

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Recommendation

100%7 out of 7 reviewers would recommend this product to a friend.
Bought this product? write a review

By DEBRAH (Fort Wayne , IN )

I got this for my daughter who has successfully recovered from drug addiction--and many of the legal prescribed drugs were worse than the illegal ones she was on. this supplement along with herbal remedies has helped her with anxiety and depression. this particular brand works well and is less expensive than some other brands

I RECOMMEND THIS PRODUCT!
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By Courtney (Downingtown , PA )

I really cannot comment much on this product because I only took it for a short period before it had a bad reaction with my stomach. I was taking it for depression but it is possibly that I was not as serotonin deficient as I thought. Still uncertain but can't say anything was the products' fault.

I RECOMMEND THIS PRODUCT!
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By julia (Brady , TX )

A slight mood enhancer. All I need.

I RECOMMEND THIS PRODUCT!
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By Elke (Medicine Hat , AB )

Good product.

I RECOMMEND THIS PRODUCT!
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By nicole (Victoria , BC )

potent and easy to swallow. no smell.

I RECOMMEND THIS PRODUCT!
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Disclaimer: The views and opinions expressed by contributors of the product reviews are their own and not necessarily those of LuckyVitamin.com. LuckyVitamin.com does not endorse or imply any medical claims from these reviews. These reviews should not be taken as recommendations but rather customer opinions of the products that they may or may not have used. Reviews are not intended as a substitute for appropriate medical care or advice and are not intended to diagnose, treat, cure, or prevent any disease. Read the full product reviews disclaimer here.

Manufacturer Info

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197 Avenida La Pata
San Clemente, CA,
Phone: 949-498-3628 Fax: 949-498-3952 Visit website

About Doctor's Best

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

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