Nutricology Fibronil 150 Capsules
Nutricology Fibronil contains Seanol-F, a patent-pending brown seaweed extract Ecklonia cava, rich in phlorotannins/polyphenols that have uniquely strong antioxidant properties. These polyphenols are 40% oil-soluble, and have a metabolic half-life of up to 12 hours. This antioxidant has a unique molecular structure, with eight interconnected rings to scavenge free-radicals as opposed to the three or four found in most antioxidants, making SEANOL-F significantly stronger than even green tea. Phlorotannins support the cardiovascular system, brain, metabolism, and general health. Fibronol also contains vitamin B1, magnesium, malic acid and aloe vera extract.
Seaweeds, or algal plants, have long been used by traditional cultures worldwide for food and medicine. Seaweeds are organized into four classes: green algae (Chlorophyceae), blue-green algae (Cyanophyceae), red algae (Rodophyceae), and brown algae (Phaeophyceae). Some green algaes, such as sea spaghetti, are used as food. Blue-green algae are found in both seawaters, and in fresh waters, such as the well-known edible Klamath Lake blue-green algae, Aphanizomenon flos-aquae. Red seaweeds include agar-agar, dulse, Irish moss and nori. Brown seaweeds include arame, hijiki, kombu and wakame, and are known for their use in Asian cuisines. Both red and brown algae are rich in polysaccharides, which are utilized for their gelling, emulsifying and stabilizing properties. Agar and carrageenan are polysaccharides extracted from red seaweeds; algin is extracted from the brown seaweed giant kelp.
Ecklonia cava, called noro-kajime in Japan, is the edible brown seaweed that serves as the source for Seanol-F. E. cava is used commercially as a source of hydrocolloids, such as alginate, and as a soup ingredient in Asia. It is also considered a source of iodine.
Seanol-F is a standardized complex of unique natural molecules from E. cava. Seanol-F contains phlorotannins, polyphenolic compounds not found in terrestrial plants but only in certain brown algal species. Phlorotannin-rich extracts of E. cava show significant antioxidant activities, including DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation. As well as modulating levels of reactive oxygen species (ROS), phlorotannins may modulate levels of PGE2, cytokines and prostaglandins.
The phlorotannins found in E. cava, which include phloroglucinol, triphlorethol-A, eckol, bieckol, dieckol, and phlorofucofuroeckol (PFF), have powerful cytoprotective activity. Triphlorethol-A helps protect cells against radiation-induced oxidative damage by scavenging intracellular ROS. It also increases the activities of cellular antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase. Phloroglucinol and eckol have been shown to scavenge hydrogen peroxide and other ROS, preventing lipid peroxidation. They also increase catalase activity and modulate the extracellular signal-regulated kinase (ERK) pathway. The crude polyphenolic fractions (CphF) of E. cava have shown especially strong antioxidant activity, much higher than that of the preservatives BHA and BHT at the same concentration. They have the capacity to scavenge superoxide anions, hydrogen peroxide and hydroxyl radicals. They may have the strongest antiradical activity among natural substances.
Dieckol and PFF have been shown in mouse studies to increase the brain level of acetylcholine by inhibiting acetylcholinesterase, and support neurotransmitter levels, with significant benefit for brain function. An in vitro study in cultured human dermal fibroblasts has shown that E. cava phlorotannins may naturally support inhibition of matrix metalloproteinase (MMP) with no cytotoxic effects. Eckol and dieckol showed strong inhibition of both NF-kappaB and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression.
Human studies show that Seanol-F supports cardiovascular function: it inhibits LDL oxidation more powerfully than the same levels of green tea catechins; it supports the body’s fibrinolysis function; it supports cholesterol within normal levels; and it supports normal production of nitric oxide (NO) in the vascular endothelium, which supports normal blood flow. Other studies offer further evidence that Seanol-F compounds may optimize NO levels. Human studies also show that it can promote daytime wakefulness, likely due to increased blood flow and oxygenation. Subjects given Seanol-F fell asleep faster, slept longer and reported increased soundness of sleep. They felt it increased their energy levels and improved their general condition.
Unlike polyphenols derived from land plants, Seanol’s polyphenols are 40% oil-soluble. They can pass the blood-brain barrier, and they have a much longer metabolic half-life than that of the usual hydrophilic polyphenols: up to 12 hours vs. typically 30 minutes. Studied since 1992, in-vitro studies, animal studies, and human trials have consistently shown that Seanol compounds have amazing health promoting promise with no evidence of toxicity.
Quality and Innovation – The NutriCology Tradition
For more than thirty years, NutriCology has been known for the highest quality, most hypoallergenic, and most cutting-edge nutritional supplements available. Physicians and healthcare practitioners around the world depend on NutriCology for their patients’ nutritional support. Originating with the ground-breaking oxidant/antioxidant work of Stephen Levine, Ph.D., NutriCology was one of the first to introduce truly hypoallergenic products to the market.
Superior Quality Control
Since 1979, NutriCology has used only the purest raw materials available, and has implemented strict quality control procedures in every stage of production, including inspection of raw materials, manufacturing, packaging, and storing. NutriCology is licensed by the California Department of Health Services, Food and Drug Branch, registration number 0021150.
Nutricology products are manufactured under the recognized principles of current Good Manufacturing Practice (cGMP), brought into final form by the FDA in June 2007. The GMP standards are applied to a wide variety of procedures associated with the manufacturing of dietary supplements, including receiving, testing, and approval of raw materials, production, and process controls, laboratory testing of labeled and packaged finished product, distribution control and accountability, and shelf life expiration testing to ensure freshness and potency.
For many years they have used the same manufacturers to produce their powder formulas, capsules, tablets, softgels, gels, and liquid products to ensure consistency. All of Nutricology's certified manufacturers meet or exceed cGMP requirements established by the FDA, as well as state and local regulations. In their facility in Alameda, California, highly trained staff bottle, label, and ship finished products. Their newly installed automatic bottling line has multiple built-in quality checks, such as weight verification and metal detection, to ensure all finished packaged products have the pre-determined physical count and are contaminant-free.
Unsurpassed Ingredient Quality
NutriCology uses only the purest and highest quality raw materials available. For example, they use only Nattokinase NSK-SD, the first nattokinase introduced into the US market, which has established standardization and quality levels for all other nattokinase. Their MicroChitosan contains small-size chitosan oligosaccharide, and Prima Uña de Gato contains TOA-free Cat’s Claw.
Taber’s Medical Dictionary defines “hypoallergenic” as: “Diminished potential for causing an allergic reaction”. Nutricology defines hypoallergenic as “free of all common allergens”, specifically, wheat, corn, soy, gluten, yeast, dairy, eggs, fish, crustacean shellfish, tree nuts, and peanuts. Many very sensitive individuals who react to supplements in general are able to tolerate NutriCology products.
Since their inception in 1979, Nutricology has used only the purest, and whenever possible, the lowest allergy potential natural ingredients. And while many of the nutrients in their formulas are synthesized from natural plant substances, which as a whole may contain antigens, the synthesizing process removes the molecules of the desired nutrient from the original substance, and in the processing, a great percentage of the antigens and allergens are left behind. The final material then has extremely low allergy potential. This is not to say that no one will react to any of these hypoallergenic formulas, as some extremely sensitive people may. However, the potential for an allergic reaction is low, and the feedback from many extremely allergic and sensitive customers is that NutriCology supplements are often the only products they are able to tolerate.
The FDA requires manufacturers to identify the presence of eight major food allergens on all product labels: milk, egg, fish, Crustacean shellfish, tree nuts, peanuts, wheat, and soybeans, as well as any ingredient derived from those foods. When an ingredient may have been derived from a common allergen, we are required by law to list that allergen on the label as a source of the ingredient, even if it does not contain any of the actual substance. For example, 100%-pure glucosamine sulfate does not contain any actual shellfish, but we are required to indicate the source material (shrimp, crab, lobster) on the label. NutriCology fully discloses all ingredients, both active and inactive on every product label, so doctors can make fully informed choices for their patients’ nutritional support.