Place 1 to 3 pellets in 1/2 teaspoon water and allow to dissolve. After dissolving, apply to child's gums. If needed, repeat every 2 hours up to 4 times per day. If preferred, mixture may be administered under the tongue. If child is persistently irretable, wakeful and restless, administer 3 pellets before bed-repeat in an hour if necessary or as directed by a healthcare professional.