Pure Encapsulations - Nutrient 950 with Metafolin L-5-MTHF without Iron - 180 Vegetarian Capsules
Pure Encapsulations Nutrient 950 without Iron is now infused with Metafolin L-5-MTHF. Pure Encapsulations Nutrient 950 without Iron is a multi-vitamin/mineral formula for optimal health. Pure Encapsulations Nutrient 950 without Iron is a complete hypo-allergenic, high-nutrient, bioavailable multi-vitamin, multi-mineral and trace element supplement. Pure Encapsulations Nutrient 950 without Iron offers an advanced mineral delivery system, and the highly desirable coenzyme forms of B vitamins to promote optimal absorption of the nutrients. In addition, Pure Encapsulations Nutrient 950 without Iron provides a high profile of free radical scavenging antioxidants. Pure Encapsulations Nutrient 950 without Iron is a gentle, hypo-allergenic formula which is well tolerated by sensitive individuals. As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6 and vitamin B12 may reduce the risk of vascular disease. Pure Encapsulations Nutrient 950 without Iron provides optimal nutritional support for all body systems. Pure Encapsulations Nutrient 950 without Iron is ideal for use by men and postmenopausal women.
Optimizing folate delivery with Metafolin (L-5-MTHF)
An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. In line with Pure Encapsulations' commitment to consistently offer innovative, science-based ingredients, Pure Encapsulations has updated a number of products, including their multivitamins, to provide Metafolin (L-5-MTHF). Metafolin is a naturally occurring, universally metabolized and active form of folate, L-5-MTHF. As such, it can be directly used in a diverse array of essential methylation reactions to support cardiovascular, neural and emotional health. Additionally, clinical evidence indicates that the bioavailability of Metafolin is superior to folic acid. In a double-blind, randomized, placebo controlled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid.
Metafolin For Optimal Folate Assimilation
By Kelly C. Heim, Ph.D.
Activation of folic acid and interconversion of reduced folate metabolites. DHF, dihydrofolate; DHFR, dihydrofolate reductase; THF, tetrahydrofolate reductase; MTHFR, methyltetrahydrofolate reductase; 5-MTHF, methyltetrahydrofolate; SAMe, S-adenosylmethionine; SAH, S-adenosylhomocysteine; dUMP; deoxyuridine monophosphate; dTMP, deoxythymidine monophosphate. Folate is a general term referring to folic acid (pteroylglutamic acid) and its reduced derivatives. Reduced, or activated folate is the coenzyme that participates in numerous methylation reactions, which include biosynthesis of nucleic acids, neuronal membrane components and neurotransmitters. Importantly, methylation of chromatin and DNA by reduced folate is an important aspect of the maintenance of healthy gene expression.
Folic acid is a synthetic, oxidized folate that requires enzymatic reduction in order to function as a methyl donor. Reductive activation of folic acid is a multi-step process. Recent evidence indicates that the efficiency of this conversion may be low and variable, possibly explaining the high plasma levels of oxidized folic acid observed in subjects receiving supplemental folic acid. The long-term effects of sustained tissue exposure to oxidized folic acid are unknown. In food, folate naturally occurs primarily in the activated form, (L)-5-methyl-THF (5-MTHF). While synthetic folic acid can be converted to 5-MTHF in the body, this process requires the enzyme 5,10-methylene tetrahydrofolate reductase (MTHFR). Highly prevalent genetic variations in MTHFR compromise the efficiency of 5-MTHF synthesis. MTHFR comprises a pivotal node in folate biochemistry, transferring methyl groups to maintain essential biosynthetic and genomic regulatory processes.
Metafolin ((L)-5-MTHF) is stereochemically identical to naturally occurring 5-MTHF. Metafolin does not require modification and can therefore execute the beneficial effects of folate regardless of MTHFR genotype. Metafolin is also efficiently absorbed and assimilated. In a double-blind, randomized, placebo-controlled intervention study of 144 women, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid. Another advantage of Metafolin is that 5-MTHF is the sole substrate for methionine synthase, which converts homocysteine to methionine to maintain vascular and neuronal health. In a placebo-controlled study of 30 women, 5-MTHF supplementation supported healthy homocysteine levels over a 3-week period. Contrary to folic acid, 5-MTHF readily traverses the blood-brain barrier to support neurological health. In a placebo-controlled trial of 123 individuals, 5-MTHF administered over 6 months promoted emotional well-being.
Over the past three decades, epidemiologic evidence has demonstrated positive associations between folate-rich diets and cellular and cardiovascular health. As an active coenzyme, 5-MTHF circumvents rate-limiting enzymatic steps to directly participate in life-sustaining methyl transfer reactions. Optimizing the efficiency of these reactions is an important dimension of diverse nutritional strategies for the maintenance of cardiovascular, hematopoietic and neurological health.
Hypo-allergenic Nutritional Supplements
Pure Encapsulations, Inc. manufactures a complete line of hypo-allergenic nutritional supplements. Pure Encapsulations' products contain absolutely no hidden fillers, coatings, artificial colors or other excipients that would disrupt or diminish the bioavailability of the ingredients. Additionally, Pure Encapsulations' products are always free of wheat, gluten, preservatives and hydrogenated oils. Pure Encapsulations believes the guidance of a qualified health professional is essential in order to maximize the effectiveness of their professional strength supplements.
Pure Encapsulations was founded to create the highest quality hypoallergenic supplements available. Since their inception, Pure Encapsulations has been the industry leader in manufacturing excellence and quality control, making Pure the choice of more than 36,000 health professionals in the U.S. health professionals and a leading brand in Europe. In 2004, Pure was acquired by Atrium Innovations Inc. Atrium Innovations Inc. is a recognized leading developer, manufacturer and marketer of science-based and professionally endorsed products for the health and nutrition industries.
Supplements for Sensitive People
Pure Encapsulations supplements are hypoallergenic. All two-piece capsules are hypoallergenic and vegetarian. There are absolutely no added coatings, binders, shellacs, artificial flavors, artificial sweeteners or colors, fragrance or excipients in our products that would disrupt or diminish the bioavailability of any of our ingredients. Pure Encapsulations does not use magnesium stearate in any of their formulas. Pure Encapsulations' products also do not contain wheat, gluten, nuts, egg, preservatives or hydrogenated oils. Furthermore, Pure Encapsulations has a comprehensive allergen SOP in place to prevent ingredient cross-contamination.
Pure Encapsulations' ingredients are selected solely on the basis of quality and purity and are provided in their most bioavailable forms. Pure Encapsulations sources premium raw materials from trusted industry leaders, including the finest suppliers from the U.S., France, Japan, Switzerland, Germany and Italy. All ingredients are tested for purity and potency by independent certified laboratories. Ingredient suppliers must meet rigorous testing and quality criteria to qualify as a Pure Encapsulations supplier.
Manufacturing and Quality Control Excellence
Pure Encapsulations manufactures their own products in their own state-of-the-art plant in Sudbury, Massachusetts. Pure Encapsulations is NSF-GMP registered in the U.S., GMP certified in Canada and exceeds the standards of the United States Pharmacopeia (USP). All manufacturing takes place in temperature, humidity and dust-controlled rooms. Each piece of equipment is dismantled and sterilized before each production run. This includes scales, mills, blenders, powder fillers, encapsulating machines and capsule counters. Pure Encapsulations' warehouse is climate controlled in order to maximize the stability of their raw materials and finished products.
Certified independent laboratories test raw materials and finished, encapsulated products. Using the most advanced equipment and test methods, including HPLC and GM-MS, these labs verify the potency and purity of ingredients. Independent microbiological testing is also performed to ensure supplement purity and safety.
Full Label Disclosure
Pure Encapsulations' supplement labels have always listed all ingredients, including the composition of the raw material. Additionally, standardizations of herbal extracts are provided to indicate primary active marker compounds. Furthermore, minerals are listed by their true elemental weights.