Douglas Laboratories CorvalenM Ribose - 12 oz. (340g)
Douglas Laboratories CorvalenM Ribose is a natural pentose sugar that is designed for the support of cardiovascular health, fatigue, energy production, and mitochondrial function. This slightly sweet d-ribose powder is rapidly dissolved and readily absorbed into the body.
Corvalen contains pure D-ribose, a safe and clinically researched ingredient that supports the natural way our bodies produce adenosine triphosphate (ATP), the energy currency of the cell. Ribose is the vital structural backbone of critical cellular compounds called purines and pyrimidines. Our bodies must have an adequate supply of purines and pyrimidines to form major cellular constituents such as our genetic material (DNA and RNA), numerous cofactors, certain vitamins, and, importantly, adenosine triphosphate (ATP). Ribose is the starting point for the synthesis of these fundamental cellular compounds, and the availability of ribose determines the rate at which they can be made by our cells and tissues. D-ribose is a structural component of DNA, RNA, ATP, GTP, flavins (FAD, riboflavin) and other important nucleotides found in all living cells. Ribose is formed naturally via the pentose phosphate pathway. This pathway is slow and rate-limited in cardiac and skeletal muscle due to an inherently low concentration (lack of expression) of the enzymes, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. The product of this pathway is ribose-5-phosphate, which in turn is converted to 5-phosphoribosyl-1-pyrophosphate (PRPP), the primary driver in the synthesis and salvage of purine nucleotides. No other compound can be used by the body for this metabolic purpose. Purine nucleotides (ATP and its precursors) lost due to ischemia, hypoxia, or genetic predisposition are replaced via the purine nucleotide pathway. This pathway is rate limited by the availability of ribose in tissue. Administration of exogenous ribose bypasses the rate-limiting steps in the pentose phosphate pathway, resulting in a significant acceleration of PRPP.
What is Corvalen?
Corvalen is pure D-Ribose - the critical building block for energy. Corvalen is the all-natural ingredient D - Ribose, clinically proven to help replenish core energy and restore quality of life. The heart, muscles and other cells in the body require substantial amounts of energy and Corvalen helps keep them fully charged. Taking Corvalen every day is an essential first step because it accelerates the natural way the human body produces energy. With Corvalen, the body quickly restores energy, improves cardiac function and reduces muscle stiffness, soreness, and fatigue.
Why does the body require D - Ribose?
D - Ribose helps the body to produce energy and is the key to rebuilding energy more quickly. Corvalen is specifically formulated for physicians to prescribe to their patients. The role of Corvalen in regulating energy synthesis gives it a special significance unlike any other carbohydrate. The D-Ribose in Corvalen, is a five - carbon monosaccharide that is a critical building block for the cellular synthesis of ATP (adenosine triphosphate). It's essential for genetic materials DNA and RNA, a number of vitamins and cofactors, and second messenger signaling cell compounds.
While every cell in the body has the ability to make D - Ribose naturally, the metabolic pathway to make D - Ribose is slow and rate limited. In times of metabolic stress the body is unable to produce D - Ribose. This limits ATP synthesis, restricts the formation of important cellular compounds, and delays tissue recovery. D - Ribose works directly to restore and sustain healthy energy pools which are critical to cellular function. No other compound regulates the energy synthetic pathways necessary to perform this important, and vital, metabolic function.
How do D-Ribose and ATP work together to produce energy?
Corvalen's active ingredient, D-Ribose, is the "energy currency" of the cell and ATP is the "power." Many situations may deplete the concentration of cellular energy, leaving tissue energy starved. D-Ribose allows the body to boost its energy by building and restoring energy quickly at a cellular level.
Without D-Robose, the process of energy synthesis grinds to a halt.
The body manufactures D-Ribose naturally from glucose via the pentose phosphate pathway. The gate keeping enzymes glucose-6-phosphate dehydrogenase (G-6-Pdhl) and 6-phosphogluconate dehydrogenase (6-PGdh) controls this complex metabolic process. Because the activities of these enzymes are poorly expressed in most body tissues, a delay in D-Ribose synthesis limits cellular energy recovery. Many situations produce a chronic metabolic stress state, leaving cells without the ability to efficiently recycle their energy supply. These stressed cells simply cannot make energy fast enough to keep pace with demand. However, D-Ribose administration significantly accelerates energy recovery, allowing cells to conserve energy substrates and rebuild depleted energy pools.
The proven solution for fatigue support is Corvalen
Getting out of bed is no longer a dream. Countless people suffer from fatigue. For many, this can leave sufferers feeling exhausted, sore and physically drained. This can be debilitating and seriously reduce core energy levels. Energy depletion unleashes a cascade of cellular reactions that contributes to fatigue and muscle soreness. When muscle tissue depletes its energy stores it causes them to become stiff and tense, putting even more pressure on cellular energy reserves. This causes calcium retention in the cell that forces potassium to activate pain receptors, which contribute to muscle pain and a reduction in exercise tolerance. Pain and soreness can further exacerbates muscle tension, using even more ATP. By fueling ATP synthesis, and restoring the cellular energy charge, D -Ribose helps reverse this energy depletion-pain cycle, reducing muscle pain, overcoming fatigue, and enhancing quality of life.
Corvalen Supports ventilatory and physical function for heart health
Corvalen administration accelerates ATP synthesis, helping supply the crucial energy reserves needed to preserve cardiovascular health and wellness or recover from hypoxic insult. 22 - 31 Clinical data shows that D - Ribose supplementation can increase the heart's hypoxic threshold, 31 support diastolic heart function, increase exercise tolerance and quality of life, and restore oxygen utilization in certain individuals. 32-33 increase exercise tolerance and quality of life in heart patients, 22â€"31 and restore oxygen utilization efficiency. 35 Metabolic stress depletes cellular energy reserves Corvalen™ availability regulates the synthesis and salvage of adenine nucleotides and restores cellular energy.
Negative Glycemic Response
Although ribose is a sugar, it is dramatically different from other sugars, such as glucose, fructose, and sucrose. Although the body uses sugars to fuel ATP turnover, ribose is metabolized differently. The body saves ribose for the important work of synthesizing energy substrates. While other sugars increase blood glucose levels, stimulate large spikes in insulin secretion, and hasten cellular fat deposition, ribose does not. Taken alone, ribose actually causes a small, transient decrease in blood sugar levels. When taken with other carbohydrates ribose helps modulate blood sugar spiking.
Trust Douglas Laboratories, The Choice Of Thousands Of Healthcare Practitioners For Over 50 Years.
Trust Douglas Laboratories for a partnership founded on a heritage of excellence. For more than 50 years, they have been at the forefront of the nutritional health industry, proudly researching, developing and manufacturing superior-quality, science-based dietary supplements to help people improve their health. Proudly earning the trust of thousands of healthcare professionals.
Trust Douglas Laboratories for best-in-class, science-based dietary supplements manufactured exclusively for healthcare professionals. We are proud to offer one of the largest and most innovative selections of over 600 premium-quality products and a comprehensive range of galenic forms (dosage and delivery), manufactured at GMP-compliant, state-of-the-art facilities.
Trust Douglas Laboratories for personalized, one-to-one consultation on the latest, most reliable science, for strategies on using nutritional health to complement your practice and for coaching to better advise your patients on the right supplements for them.
About Douglas Laboratories
Back in 1955, Sam Lioon, founded Douglas Laboratories on a simple promise: provide the highest quality nutritional supplements available with the highest level of personal service-anywhere. And with that promise began a legacy of leadership-and a never-ending quest to exceed their customers' expectations to Raise the Standard for Nutrition and Wellness.
Today that legacy lives on as Douglas Laboratories proudly joins the Atrium Innovations group of companies. Atrium Innovations is an international company and global leader in the development, manufacturing, and marketing of dietary supplements, specialty fine chemicals, and active cosmetic ingredients.
Douglas Laboratories is supported by more than 300 Douglas Laboratories employees all dedicated to keeping the promise Sam made 50 years ago. Raising the Standard is more than a slogan-it's a promise. As they enter their second half-century, Douglas Laboratories will continue to keep their promise to Raise the Standard with a custom approach to ytheir patients' nutrition and wellness. With custom formulations ytheir patients can't find anywhere else. Custom labels. Custom daily packs. And the industry's largest and most innovative product line. And they'll back up their promise with the kind of stringent criteria many other companies overlook, such as:
(cGMPs) current good manufacturing practices.
ISO 9001 Certification and ISO 17025 Accreditation of their laboratories.
The industry's first fully electronic, bar code driven, paperless manufacturing system to pass the FDA's rigorous audit. Their exclusive Veri-Match labeling system, ensures verification prior to production and release of ytheir products.
(SOPs) standard operating procedures.
VCP (Vendor Certification Program) ensures raw material safety and quality.
Experienced, on-staff Ph.D's, utilizing three full-service laboratories, outfitted with the latest analytical equipment.
State-of-the-art manufacturing, including ultra high-speed encapsulating machines, capable of producing over 35 million capsules and tablets daily!
Full compliance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002, assuring safety and uninterrupted flow of all raw materials.
Douglas Laboratories continues to lead the way with clinical trials designed to validate the efficacy of their products. Their world-renowned Ultra-Preventive X (Ten) was rated the #1 multivitamin in the professional healthcare market, and their Vita-Big-Kids was rated the #1 children's multivitamin overall by the independent Comparative Guide to Nutritional Supplements. Their commitment to help support patient outcomes is ongoing; look for their new in-office patient education posters, easy online ordering from their website and more innovative ideas designed to help ytheir practice grow in the days ahead.
But most of all, they're proud of the many long-standing relationships they've enjoyed with so many customers over the years, and the many great friendships they've made along the way. It's not an exaggeration to say that they truly enjoy what they do, enjoy coming to work each and every day.