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Biotics Research
90 Capsules
$26.90



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About Biotics Research

Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.

Contact Biotics Research

6801 BioticsResearch Dr.
Rosenberg, TX, 77471
http://www.bioticsresearch.com
800-231-5777

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Item Code: 105808UPC Code: 055146027000
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Biotics Research Tri-Chol - 90 Capsules

Biotics Research Tri-Chol supplies a unique combination of botanical components with specific micronutrients, with the focus on inositol hexaniacinate, to help maintain cholesterol levels that are already within a normal range.

Risk factors in cardiovascular disease
Coronary artery disease (CAD) is the leading cause of death in most industrialized nations, including the U.S. Most data regarding risks associated with cardiovascular disease in general, and CAD in particular, pertain to middle-aged men. However, after the age of 60, CAD is the primary cause of death among women .  Atherosclerosis accounts for about 50% of all female deaths, although most of these occur after the age of 70 . Primary risk factors for both genders include hyperlipidemia, hypertension, smoking, diabetes, work-related stress, age, hyperhomocysteinemia and obesity.  Recent studies indicate that physical inactivity represents an additional lifestyle risk factor that ranks as high as any other, and high alcohol consumption increases the risk of death from cardiovascular disease.

Hyperlipidemia and cardiovascular disease
Elevated serum cholesterol and serum LDL and depressed HDL are interrelated risk factors for CAD. High postprandial serum triglycerides are also a risk factor, though the correlation is not as strong. Recent studies indicate these risk factors become more prominent in post-menopausal women as well. After the age of 80, elevated serum cholesterol does not seem to increase the
risk of CAD for men, though it may still be a factor for elderly women. The interrelationships among the various risk factors are complex, and in subjects with more than one factor, there is a synergistic effect among various factors. For example, hyperlipidemia increases blood pressure.

The liver clears dietary cholesterol, and feedback mechanisms help regulate circulating cholesterol levels. When the cholesterol input increases, cholesterol tends to accumulate in hepatocytes.  This in turn leads to down-regulation of hepatic receptors that clear LDL cholesterol from the bloodstream.  In contrast to LDL, HDL functions mainly to move excess tissue cholesterol to the liver for excretion. Elevated serum HDL, or lowered serum cholesterol/HDL ratios correlate with decreased risk of cardiovascular disease.

Cholesterol oxidation and cardiovascular disease
Elevated serum cholesterol increases the probability of oxidation of LDL-cholesterol (LDL-C). Oxidized LDL-C is cytotoxic to arterial endothelial cells.  According to the oxidation hypothesis of cardio-vascular disease, partially oxidized LDL-C is selectively taken up by monocytes and macrophages that evolve into lipid-filled foam cells. Scavenger receptors on these cells absorb
oxidized LDL. Unlike the LDL receptor, the scavenger receptor is not down-regulated by high levels of cytoplasmic cholesterol, and the cells continue to accumulate oxidized LDL indefinitely.  In addition, it also promotes the proliferation of smooth muscle cells, which aggregate at athero-sclerotic lesions. Furthermore, oxidized LDL-C stimulates the production of chemotactic factors
that attract macrophages into the subendothelial space. Oxidized LDL can activate inflammatory responses that generate free radicals, inducing further oxidative damage. These events are thought to cause “fatty streaks” and leading eventually to the build up of plaque deposits in arteries.

Primary prevention of cardiovascular disease
Most strategies for reducing the risk factors for coronary artery disease in women and men are the same. Increased physical activity, decreased hypertension, cessation of cigarette smoking, decreased serum homocysteine, and lowered serum LDL-C are generally recommended. For American men, there is a 2 to 3 percent decline in the risk of CAD for every 1 percent reduction in
total serum cholesterol level.  Extrapolation of these figures to premenopausal women has been questioned because estrogen modifies serum lipids. An increase in serum HDL cholesterol levels is a strong predictor of decreased CAD risk.  Extensive research indicates nutritional status affects the levels of serum lipids. The consumption of certain saturated fatty acids, such as palmitic acid, can increase serum cholesterol due to decreased cholesterol turnover and are therefore considered atherogenic, while consumption of un-saturated fatty acids tends to lower serum LDL.

Specific nutrients modulate cholesterol levels
Niacin (Inositol hexaniacinate). Oral niacin low-ers LDL-cholesterol, Lp(a), triglycerides and fib-rinogen levels. Furthermore, oral niacin was shown to reduce mortality by 11% compared to the group receiving a placebo, while cholestryramine was associated with an increased mortality. A comparison of niacin and lovastatin found that while lovastatin produced greater reductions in LDL-cholesterol, niacin provided better over-all results. Thus niacin increased levels of HDL, while lovastatin had a minimal effect on HDL.  Furthermore, niacin resulted in a 35% reduction of lipoprotein (a), while lovastatin had no effect on this parameter. Another study focused on middle aged men with normal total serum cholesterol levels, but also with low HDL levels . In this group, niacin was found to raise HDL levels by 30%.

One of the safest forms of niacin is inositol hexaniacinate, which has long been used in Europe.

Chromium. Chromium is an essential nutrient for carbohydrate and lipid metabolism. Significant numbers of Americans consume less than the RDA for chromium. The dietary requirement for chromium is believed to increase with glucose intolerance. When type 2 diabetics were supple-mented with 1000 mcg of chromium per day, for four months, the subjects had lower glycosylated
hemoglobin, plasma cholesterol, blood glucose, and insulin levels than controls consuming a placebo.  In another study, patients with type 2 diabetes supplemented daily with 200 mcg of chromium complexed with niacin for 8 weeks experienced slightly lowered plasma triglycerides, LDL cholesterol and fasting blood sugar.

Choline. Choline is both a methyl donor and a building block of phosphatidylcholine. As the major phospholipid of lipoproteins, phosphatidylcholine is needed to move cholesterol and triglycerides out of the liver. Choline administered to lab animals decreased the amount of fat associated with the liver, but not carcass fat. Diabetic rats often display fat accumulation in the myocardium.  Treatment with choline and methionine dramatical-ly reduced fat buildup and improved cardiac per-formance in these animals. Earlier studies had demonstrated that dietary choline increased biliary lecithin and cholesterol excretion.

Botanical support of lipid metabolism.
Commiphora mukul. The gum resin of C. mukul contains gum, essential oil and sterol derivatives, including guggulsterone, guggulsterol and diterpenoids. In Ayurvedic practice, mukul has a hypocholesterolemic effect. Chronic feeding of guggulsterone to rats was associated with increased uptake of LDL by the liver due to increased hepatic LDL receptor activity. In a double blind, placebo controlled experiment, hypocholesterolemic patients supplemented with mukul in addition to a fruit/vegetable enriched, prudent diet exhibited a 12.5% decline in LDL-C as compared to controls. In the mukul-treated group serum lipid peroxide levels declined by 33% after 12 weeks. Side effects were observed in a few patients, which included headache, mild nau-sea, and eructation. Mukul resin also decreased experimentally-induced inflammation in lab animals

Alisma orientale. The dried roots and stems of this plant contain sterol derivatives called alisol A and B, alisol monoacetate and the essential oil epialsol A, as well as B vitamins and niacin. As used in traditional Chinese practice, this herb enters the kidney and bladder channels and is said to leach out dampness and associated stagnation. It drains dampness without injuring yin energy. In animal models, orally administered terpenoid extracts from A. orientale were shown to inhibit type II and type III allergic reactions mediated by cellular and humoral mechanisms.

Polygonum cuspidatum. The dried roots and stems of P. cuspidatum contain resveratrol, and its gluco-side, polydatin, as well as emodin, polygonin, glucofragulin and physcion together with flavonoids. Hypercholesterolemic patients administered this herb were reported to exhibit decreased cholesterol levels. Resveratrol exhibits protein tyrosine kinase activity implicated in signal transduction, regulating the cell cycle and other essential functions.

Polygonum multiforum. This plant contains approx-imately 1% as active principles, including emodin, emodin methyl ester, rhein, chrysophenol and chyrsophanic acid. It also contains glycosides and lecithin. This herb enters liver and kidney channels according to Chinese traditional practice.  It reportedly increases coronary circulation, reduces heart rate, and reduces intestinal uptake
of cholesterol. Preparations reduced blood cholesterol levels in experimentally-induced hyper-cholesterolemia in rabbits. When individuals with elevated blood cholesterol were given decoctions of P. mulitiforum, most subjects (78/88) had lowered cholesterol levels, while a few (8/88) had elevated cholesterol and 2/88 had no change.  Facial flushing or increase bowel movements were reported possible side effects.

All Bitoics Research Items are Gluten Free!

Currently, it is believed that gluten sensitivity (gluten intolerance) effects almost 700 million people worldwide. Gluten intolerance covers a wide spectrum of conditions, including celiac disease and wheat allergy. Symptoms include bloating, abdominal discomfort, pain, diarrhea, headaches and migraines, lethargy, attention- deficit disorder, muscular disturbances, bone and joint pain, and even schizophrenia.

At Biotics Research, they provide superior nutritional supplements to benefit the patient health. ALL BIOTICS RESEARCH PRODUCTS ARE GLUTEN FREE and they always have been! With Biotics Research, there's no need to search through a catalog for all of the ingredients, or review label after label. You can use any product from Biotics Research without concern because ALL BIOTICS RESEARCH PRODUCTS ARE GLUTEN FREE !

Quality Control - What Sets Biotics Apart

The Biotics Research way!


At Biotics Research Corporation, we manufacture our own branded products on site, in our own state of the art facilities, allowing for complete control of the entire manufacturing process. In our on-site laboratories, the highly skilled members of our Quality Control Unit, utilize modern, sophisticated technologies and validated analytical methods to test incoming raw materials, monitor manufacturing processes, perform in- process testing, and test all finished products prior to their release for shipment. In fact, many aspects of our cGMPs (current Good Manufacturing Practices) exceed the new, recently enacted FDA guidelines for dietary supplements in order to ensure the safety and effectiveness of our products.
The Quality Control Unit (QCU) has the authority to approve and/or reject all specifications and procedures associated with the production and release of all raw materials, packaging materials and finished products, including test methods and results, instrument calibrations, and processing records. The QCU conducts all internal audits, and validates and audits all raw material and packaging suppliers and service vendors as well.

All incoming raw materials are subject to appropriate testing prior to their release for production. Tests conducted include identity, potency, biological activity, microbiological, including bacteria, yeast and mold (including aflatoxins) and heavy metals (arsenic, cadmium, lead & mercury). Retained samples are maintained of all raw materials and finished products for future testing requirements (raw material stability and finished product expiration date verification).

All bulk finished products (tablets & capsules) are inspected and subjected to metal detection prior to being sampled by QC. They are then subject to appropriate disintegration and/or dissolution testing, and potency testing prior to being released to packaging. All liquid and powder products are tested for potency prior to packaging as well. Finally, microbiological testing is performed on all finished products and document reconciliation is completed prior to being released for shipment.

All testing is performed by our trained QC personnel using state of the art laboratory instrumentation including High Pressure Liquid Chromatography (HPLC), ICP, Atomic Absorption Spectrophotometry (AA), gel electrophoresis, FT -IR, Ultra Violet spectrophotometry, Thin Layer chromatography and Gas Chromatography-Mass Spectrometry (GC- MS).

Unlike many companies that are struggling to meet the new GMP requirements established by the FDA, companies that are being regulated into implementing quality programs, extensive Quality Control has always been part of the corporate fabric of Biotics Research Corporation.

From day one, the mantra of Biotics Research Corporation has been “Innovation and Quality.” Our goals remain unchanged – utilize innovative ideas and carefully researched concepts with advanced techniques to develop products of superior quality and effectiveness – bringing you “The Best of Science and Nature”.

Suggested Use
One (1) capsule twice each day with meals as a dietary supplement or as otherwise directed by a healthcare professional.

Warnings

Not recommended for pregnant or lactating women.  Keep out of reach of children. 

Ingredients

Biotics Research - Tri-Chol - 90 Capsules
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving %DV*
Niacin (as inositol hexaniacinate) 150mg 750%
Chromium (from vegetable culture) 100mcg 83%
Choline (as bitartrate) 30mg *
Proprietary Blend 320mg *
Guggul extract (Commiphora mukul)(tree sap) *
Fo-Ti (Polygonum multiflorum)(root) *
Alisma (Alisma orientalis)(rhizome) *
Polygonum cuspidatum (rhizome) *
Bitter Orange extract (Citrus aurantium) (fruit) *
*Daily Value Not Established.
†Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
 
Other Ingredients: Gelatin, water and glycerin.
About Biotics Research

Biotics Research Corporation has been a leading manufacturer of specially designed nutritional products for over thirty years. Our mission remains constant: to be the benchmark of excellence in nutritional science, technology and service, providing the clinician with reliable, innovative products of superior quality as well as the highest level of customer service.


6801 BioticsResearch Dr.
Rosenberg, TX, 77471
Phone: 800-231-5777
Fax: 281-344-0725
http://www.bioticsresearch.com
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    *The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

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