The good news about Avé™
A marvel of nature, a triumph of science.
Ave (Patented) Fermented Wheat Germ Extracts Standardized To Methoxy-Substitutes Benzoquinones (Avemar Pulvis)

Introducing Avé, the dietary supplement with Avemar®, a uniquely beneficial natural compound that has been the subject of more than 20 peer-reviewed publications describing in vitro, in vivo and human clinical trials.

Its development was initiated by Dr. Albert Szent- Györgyi, recipient of the Nobel Prize for the discovery of vitamin C. He theorized that supplemental quantities of the naturally occurring compound, Methoxy-Substituted Benzoquinones (DMBQ), would help regulate the processes of cellular metabolism and support mechanisms of immune system regulation.

Avemar is made from wheat germ fermented by baker’s yeast through a patented process (US patent# 6,355,474), standardized for DMBQ. Studies conducted in the US, Hungary, Israel, Italy, Austria and Russia with Avemar prove Dr. Szent-Györgyi theories correct, with such dramatic results, its hard to believe its all-natural.

* Supports cell metabolic regulation*
* promotes immune system modulation*
* Maintains healthy cellular & humoral (Th1/Th2) immune balance*
* Promotes optimal NK cell targeting ability and the coordinated response of macrophages, B-cells * T-Cells*

From Nobel Prize to Prized Supplement . . .

Avemar's development was inspired by the work of Hungarian scientist Dr. Albert Szent-Györgyi, awarded the 1937 Nobel Prize in Medicine for describing the essential role of vitamin C in the life-sustaining processes of cellular metabolism.

Dr. Szent-Györgyi recognized that methoxy-substituted benzoquinones play essential roles in regulating and fine tuning metabolism at the cellular level and theorized that supplemental levels of methoxy-substituted benzoquinones could help the body respond to internal and external stresses.

In recent years, a new generation of Hungarian scientists has continued Dr. Szent-Györgyi's work by developing a method of manufacturing an all-natural and standardized source of methoxy-substituted benzoquinones by fermenting wheat germ with baker's yeast through a patented process. (U.S. Patent #6,355,474).

This product is now available as a dietary supplement in a once-a-day, pleasant tasting instant drink mix, and is being studied in hospitals and recommended by doctors around the world. It is available in the U.S. under the brand name Avé, and as Avemar outside the U.S.

How does Avé work?

1. Avé Supports Cell Metabolic Regulation
2. Avé Promotes Immune System Regulation
* Enhance the ability of T-cells to respond to antigen presentation, and B-cells to respond to activation and produce appropriate antibodies
* Normalize balance of cellular and humoral (Th1/Th2) immune function
* Enhance Macrophage functioning
3. Avé Enhances NK Cell Targeting
Avemar helps the immune system identify invaders for attack. Immune system enemy invaders try to hide from the immune system’s Natural Killer (NK) cells by displaying a surface molecule called MHC-1.
MHC-1 tells NK cells, “don’t attack me, I’m one of the good guys,…but, research shows Avemar suppresses the invading cell’s “mask” (MHC-1) resulting in increased NK cell targeting and immune system clearing.

More Info: http://avemarusa.com/faqs.html

Avé, dietary supplement from American BioSciences, named “Best New Product of the Year”

(Blauvelt, NY) American BioSciences, Inc. has earned the “Best New
Product of the Year Award” for its dietary supplement product Avé™. The
award, called “NutrAward,” was presented at the annual Natural Products Expo
West/SupplyExpo 2006 tradeshow in Anaheim California, the largest gathering
of the natural, organic and healthy product industry. Avé was introduced in
May of 2005 and is the firof healthy cell metabolism and immune system
regulation that are altered by injury and physical stress.
“Over 15,000 new products or ingredients are introduced into the
natural products market every year,” said Todd Runestad, Science Editor of
Functional Foods & Nutraceuticals magazine, which covers the industry.
Companies were invited to submit new products for NutrAward consideration by
an independent panel of industry experts and medical and scientific
researchers, who narrowed the field to three semifinalists by judging each
on six criteria: scientific merit, efficacy, safety, innovation, market
potential and ability to increase industry credibility. The final NutrAward
winner was determined by the vote of the 44,000 attendees of the 25th annual
Expo West/SupplyExpo tradeshow.

The NutrAward is highly valued within the industry. Companies seeking
to win it must submit the research conducted on their products to a rigorous
scientific review performed by independent industry and academic experts in
natural products.
“We have been in the forefront of encouraging companies to make
comments about their products based on science, so we take a look at things
pretty critically, and the Avé and Avemar products looked good in that
context,” said Richard D. Kreider, PhD, Professor and Chair of the
Department of Health, Human Performance and Recreation, Director of the
Exercise and Sport Nutrition Laboratory at Baylor University, and a member
of the Nutracon scientific review panel. “There were data from both animal
and human clinical trials to validate Avemar's safety and efficacy.” He also
commented, “The studies were well done, from both the theoretical and
applied standpoints, and the results showed it had both mechanistic and
overall immunological impact.”
The Avemar science reviewed by the expert panel included results of
over 100 experiments in cell lines, animal and human subjects, described in
more than 20 publications in peer-reviewed medical journals such as the
British Journal of Cancer, Pancreas, The International Journal of Oncology,
Lupus, Nature Biotechnology, and others.
Studies conducted in the US, Hungary, Israel, Russia and other
countries show the compound works to optimize metabolism and immune system
function in conditions in which either or both are challenged. Use of
Avemar as a dietary supplement has been shown to support mechanisms of cell
metabolic regulation, so that cells in our bodies use glucose, their basic
fuel source, at a steady rate through healthy oxidative pathways. Healthy
metabolic rate and pathways can be altered by injury and stress resulting in
a variety of health conditions. Injury and stress can also alter immune
response, and Avemar has been shown to support mechanisms of innate and
acquired immune system regulation. Avemar use improves the balance of
cellular and humoral immune activity, the ratio of Th1 and Th2 cytokines,
promotes optimal NK (Natural Killer) cell recognition, and the coordinated
response of macrophages, B-cell and T-cells.

In Hungary, where Avemar was invented and where it is manufactured,
Avemar is classified as a “medical food,” and is a standard treatment and
approved therapy for many health conditions. It is available as a food
product or dietary supplement in many European and Asian countries.
American BioSciences completed the US FDA process of establishing Avemar as
GRAS (Generally Recognized As Safe) a designation that allows its use in
foods, beverages and dietary supplements. Avé is a dietary supplement
instant drink mix and is the first US product to contain Avemar.
“We are very pleased to see the prestigious 2006 NutrAward added to the
recognition Avemar and Avé have received,” said David Wales, President of
American BioSciences. Earlier this year, Avé received the “Product Merit
Award”ts inventor Dr. Mate Hidvegi.
“It is our hope that the publicity of winning the NutrAward will bring
Avé and the research behind Avemar to the attention of a broader spectrum of
the public and medical community and provide new health care opportunities,”
added Rick Jahnke, vice-president and co-founder of American BioSciences
“It has always been our goal to focus first and foremost on helping people
achieve their health potential. We work with university and private
researchers to identify extremely well researched natural compounds that
have never been marketed as natural compounds, often because synthetic
versions of them are on track for drug development. Avé and Avemar prove
that the science of natural compounds can rise to the level of the most
powerful drug compounds, but without toxicity issues because they are
basically food compounds. The dietary supplements we sell are the same
compounds used in the research, and peer-reviewed publications provide
accurate, third party information on safety and efficacy.”
Avemar research can be found by searching the National Institutes of
Health website, www.pubmed.org, with the search term, Avemar, and/or
“fermented wheat germ,” and at the website, www.avemarresearch.com. For
more information on Avé, call toll free 1-888-884-7770, or visit online at
www.americanbiosciences.com