USP Labs - Recreate Thermogenic Bonus Size with Caralluma Fimbriata - 120 Capsules
Bonus Size - 33% More Free! (in comparison to original 90 count version)
Introducing USP Labs' Recreate - the award winning thermogenic! Looking for a thermogenic but don't want a bunch of different stimulants? Traditionally, the "strength" of thermogenics are judged by how much of a "kick" they provide – based upon their stimulant level – not how much they actually perform as a thermogenic. While stim-based thermogenics can be very effective, not everyone who wants the benefits of a thermogenic wants a lot of stims…Some people are just very sensitive, some can't take them after a certain time of day and some simply just don't want them. Until now, low or non-stim burners simply didn't do the trick…Fortunately, USP Labs has formulated Recreate – the thermogenic for those who are looking to get cut without having to use a myriad of different stimulants.
Recreate was designed to support thermogenesis without large amounts of many different stimulants. By focusing on key ingredients that can work with your body, Recreate can be the answer. For example, a key ingredient in Recreate has been used for centuries to reduce appetite and food cravings.
Here's an ingredient breakdown:
An adenlyate cyclase activator, which in turn increases intracellular levels of cAMP (cyclic adenosine monophosphate), which eventually works to stimulate lipolysis in adipose cells. Forskolin bypasses the receptor and directly activates adenylate cyclase, potentially obviating the need for "cycling" on and off of the product every few weeks. Another potential benefit is that accumulation of cAMP in skeletal muscle may provide an anti-catabolic/anabolic effect as well.
A 12 week study, which evaluated body composition, found that when they gave forskolin (i.e., 25 mg twice daily by mouth) to a group of 15 non-active, sedentary, overweight/obese men (without having them change their normal habits), they were able to reduce body fat percentage by a statistically significant (p = 0.05) 4.14 ± 4.47%, versus the placebo group which reduced body fat percentage by 0.96 ± 1.66%.
In addition, they were able to lose a statistically significant amount 4.52 ± 5.74 kg (i.e., approximately 9.9 lb) of fat mass in the forskolin group (placebo lost 0.51 ± 1.91 kg).
While not statistically significant, a trend (p = 0.097) was noted for lean body mass gained in the forskolin group, when compared to baseline; the subjects in the forskolin group gained approximately 8.2 lb of lean body mass (3.71 ± 4.07 kg), while the placebo group gained 1.57 ± 2.56 kg (6).
Other studies have found similar results, while some have found an apparent lack of effects in different populations (e.g., women). Still, overall, the use of forskolin for the altering of body composition seems to be effective.
If there were one potential downfall of forskolin, it would be that the body still has a few mechanisms to reduce cAMP levels, either via modulation of adenylate cyclase activity or degradation of cAMP itself. Caffeine has the potential to work against such mechanisms to increase the effects of forskolin by inhibiting the negative modulation of adenylate cyclase via adenosine antagonism, which is most probable, or potentially (less likely) it's phosphodiesterase inhibiting effects.
Caffeine is a well known stimulant, thermogenic agent and stimulator of fat oxidation in humans. No fat loss formula would be complete without it & the reason caffeine is included is due to this facts and the synergistic effects noted above. Recreate utilizes just enough caffeine to do the trick, but not the absurd amounts found in many thermogenics today.
An extract (performed in a very particular way) of olive leaf, was shown to possess thyroid stimulatory properties when it increased T3 levels by nearly 150% as compared to the control group in a study using animal models weighing 125-150 g each, using the highest dose group (i.e., a dose of 500 micrograms).
Here is the best part:
Unlike many plant extracts which only have an effect in animal models when the dose employed is the equivalent to a human consuming their entire bodyweight of the substance per day, this actually worked in animal models at a very low dose. Additionally, the thyroid stimulating effects with this plant in animal model were dose-dependent.
Again, a very precise extract of this substance has been shown to inhibit the enzyme 11-B-hydroxysteroid dehydrogenase type 1, both selectively and very potently in vitro. In addition, it was shown to do so in animal muscle and adipose cells, in vitro.
Why is this good?
11beta-HSD1 is an enzyme responsible for converting the very weak glucocorticoid, cortisone, into the much more powerful, cortisol. We all know that excess cortisol can hamper your progress in the gym, and with the stress of living in our modern world, it's certain that few people don't have elevated cortisol levels. Unfortunately, this particular enzyme works against what we all as athletes and bodybuilders would like and works to increase cortisol levels.
In addition, another sad bit of news is that activity of this enzyme only seems to increase as we get older. By inhibiting 11beta-HSD1, it is thought that it could be used to potentially reduce body fat and improve insulin sensitivity. Additionally, a beneficial effect upon muscle mass would be expected.
A very specific extract of this plant was shown to reduce waist size by almost one and a quarter inches in only 8 weeks, while decreasing appetite by approximately 20% as compared to placebo in a study using 23 human male and 39 female subjects (25 subjects completed the study in the active and placebo groups), which were overweight (i.e., BMI > 25 kg/m2).
In addition, those taking the active ingredient (500 mg twice daily of a specific extract) reduced consumption of sweets, refined sugars, cholesterol and saturated fats by the conclusion of the study as compared to placebo. At the same time, consumption of fruits, vegetables and fish didn't change. In other words, they better food choices, while also eating less. The group taking the caralluma lost 1.5 kg (approximately 3.3 lb) of fat mass as well, over the course of the study.
It has been used for centuries by tribal populations that wished to suppress their appetite. It also has a well-established safety record. As far as how it works, it is thought that steroidal glycosides present in the plant may increase ATP in the hypothalamus, potentially "tricking" it into thinking that energy or food intake is sufficient so there is no need to increase appetite.
Microtea Debilis Extract- Cirsimarin
This compound has demonstrated some impressive properties. Specifically, it has been shown to be 20 times more potent at stimulating lipolysis in vitro, using fat cells of an animal model, as compared to caffeine. It has also been shown to possess potent anti-lipogenic effects and to decrease adipose tissue deposition in an animal model.