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Thorne Research - Methyl-Guard - 180 Vegetarian Capsules

Important Homocysteine Metabolism Cofactors

Item #: 109603
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Serving Size: 3 Capsule(s)
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Thorne Research - Methyl-Guard - 180 Vegetarian Capsules

  • Code#:109603
  • Manufacturer:Thorne Research
  • Size/Form:180  Vegetarian Capsules
  • Packaged Ship Weight:0.45
  • Servings:60
  • Dosage Size:3  Capsule(s)
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Thorne Research Methyl-Guard - 180 Vegetarian Capsules

Maintaining a normal plasma homocysteine level has joined elevated cholesterol and triglyceride levels as a leading concern for maintaining good cardiovascular health. Plasma homocysteine levels are also associated with maintenance of bone, female reproductive, cognitive, and neurological health. Numerous studies advocate the lowering of plasma homocysteine levels via nutritional supplementation. A number of biochemical imbalances that can raise homocysteine levels can be addressed by supplementing with the appropriate nutrient cofactors. For example, folic acid (as L-5-methyltetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine) are involved in recycling homocysteine to the amino acid methionine, while the breakdown of homocysteine into the beneficial amino acids cysteine and taurine can be facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6). Studies have shown these nutrients can help maintain normal plasma homocysteine levels.

  • maintains good cardiovascular health by supporting normal homocysteine levels
  • contains the active forms of folate and vitamin B12 (5-MTHF and methylcobalamin)
  • helps maintain good cognitive and neurological health
  • supports bone and female reproductive health

In addition to the beneficial homocysteine effects of the ingredients in Methyl-Guard, folic acid has been shown to help maintain the normal function of the arterial walls, allowing them to dilate more readily and enhance circulation. Homocysteine levels can be increased in individuals in which the enzymatic reaction responsible for converting folic acid to the active methyl donor L-5-methyltetrahydrofolate (5-MTHF) does not function properly; therefore, Methyl-Guard contains 400 mcg of active 5-MTHF per capsule.

Maintaining normal homocysteine is important for good cognitive health. A deficiency in homocysteine-metabolizing cofactors is commonly seen in the elderly, which can result in an increase in homocysteine levels with advancing age. Vascular structures can be adequately maintained when plasma homocysteine levels are normal by elevated homocysteine, thus helping to maintain cognitive health. Elevated homocysteine levels associated with aging, as well as low levels of folic acid and vitamins B6 and B12, can result in the decreased methylation of numerous substances, including DNA and proteins, decreasing the integrity of vascular structures and neurons. Providing the nutritional cofactors for homocysteine metabolism provides support for a healthy brain.

Methyl-Guard was the first dietary formula on the market to promote homocysteine metabolism and is the only one that contains the active, body-ready forms of the homocysteine-metabolizing nutrient cofactors.

Dr. Michael Lebowitz D.C. Recommends:
Methyl-Guard was created to decrease homocysteine levels in the body, which is a risk factor for atherosclerotic heart disease. Methyl-Guard may also enhance carnitine, CoQ10, taurine, and pantethine levels as well as SAM levels (possibly helping myelin formation). Methionine is de-methylated in the body into homocysteine by two interconnected pathways. Methionine then must be re-methylated to produce S-adenosylmethionine (SAM) which is the body's "universal methyl donor". SAM is necessary in re-myelinization and the formation of carnitine and CoQ10. If homocysteine is not re-methylated it can damage endothelial cells, interrupt collagen synthesis and cross-linking, and cause heavy oxidant formation. The break-down of homocystein is also necessary to produce taurine and cysteine, which are essential for proper body function. Methyl-Guard provides the essential cofactors necessary in the re-methylation and trans-sulfation pathways of methionine so that homocysteine levels are decreased and SAM levels are increased. It contains Betaine, Methylcobalamin, Folinic Acid, and Pyridoxal 5'-Phosphate.

Thorne Research's Mission
At Thorne Research, their mission is to enhance the health and well-being of people by providing superior dietary supplements that have the highest level of quality and purity – thereby creating the most respected and valued company in the dietary supplement industry.

The Thorne Difference.
For more than 25 years, Thorne has relentlessly pursued the highest possible quality and bioavailability in dietary supplements. At Thorne, they actually manufacture products that they sell – a key difference that allows Thorne to control every aspect of the manufacturing process and ensure that every Thorne product is in pure, completely hypoallergenic form, and without the common additives, flowing agents, and binders used throughout the industry.

A few other companies have tried to do what Thorne does, and many others claim to have the same philosophy and quality, but nobody has been able to duplicate what Thorne's clients call "Thorne Quality." Thorne has changed the industry in many ways over the past two decades, and they continue to raise the bar and set new standards in product formulation, raw material purity, manufacturing, and quality control.

Thorne's Commitment to Purity
Practitioners have become accustomed to seeing the vague "We use only the purest ingredients" in the promotional materials of almost every dietary supplement company. Perhaps these companies truly believe that. Perhaps they don't know any better. Nevertheless, Thorne Research, for more than 25 years, has been the standard by which companies in the industry are judged for product purity. Practitioners rely on Thorne as the company they trust for their extremely allergic, chemically sensitive, and immune-compromised patients.

Purity Takes Extra Effort
For example, instead of purchasing prediluted vitamin D, as other companies do, Thorne performs its own dilution to avoid detrimental ingredients, such as the preservatives or lactose that are found in many commercially available dilutions. Why must vitamin D be diluted? Because in its pure form, it is too concentrated to safely blend into a vitamin product. Pure vitamin D is 40 MILLION International Units (IU) per gram. The RDA for adults is 600-800 IU per day. To ensure proper mixing, it must be made into a dilute powder that flows and does not lose potency. So, unlike companies that use prediluted vitamin D that contains unacceptable excipients and preservatives, at Thorne, pure pharmaceutical vitamin D is first blended with pure mixed tocopherol vitamin E, and the resultant stable vitamin D is then blended with hypoallergenic cellulose powder. The final powder is blended in a large tumble blender and subsequently analyzed. Not only is the final product stable; it is also hypoallergenic and can be mixed homogeneously and at a safe level with other powders. Just as with vitamin D, Thorne utilizes similar processes for other raw materials, such as vitamin K, leaving it to other companies to purchase commercially available raw materials filled with unacceptable ingredients and preservatives.

Ingredients You Don't Want
Magnesium Stearate: Good for speed-hungry encapsulating machines. Not necessarily good for you. Manufacturing encapsulated dietary supplements isn't easy. Pure powdered ingredients are difficult to mix because they are either extremely dry, sticky with botanical oils, or attract unwanted moisture. So most manufacturers add magnesium stearate and other agents such as lactose and dextrose to make the powder flow quickly and easily through their high-volume machines. Problem is, these additives may compromise the bioavailability of the nutrients in the supplement, and might cause allergenic problems. At Thorne, they take a different approach.

Thorne will never utilize large fatty acid excipients in its manufacturing processes – ingredients such as magnesium stearate or stearic acid. These excipients are utilized as flowing agents to ensure that maximum productivity is obtained from capsuling and tableting machines. There are documented detrimental effects directly attributed to long chain fatty acids utilized as manufacturing flowing agents. Every qualified pharmaceutical compounder recognizes that large fatty acids, such as magnesium stearate, can interfere with product dissolution and influence absorption. Virtually all companies, because of the economic impact, ignore this data. As with most industries, the bottom line dictates the level of quality. The dietary supplement industry has one exception: Thorne Research, the company that does not compromise. Nevertheless, if a company cannot manufacture products without using detrimental excipients, they should not allude to being either "hypoallergenic" or "pure."

The Bottom Line?
Thorne is the only hypoallergenic dietary supplement manufacturer with the highest degree of purity that you – and your most severely allergic, chemically sensitive, and immune-compromised patients – can truly trust.

Quality Ingredients: A Higher Standard
At Thorne, they are committed to setting a higher standard of quality when it comes to ingredients. To produce their truly hypoallergenic encapsulated supplements, Thorne uses only the purest and finest ingredients available.

Every manufacturer has two basic options when purchasing raw materials: purchase either truly pure raw materials, or purchase raw materials to which substances have been added to facilitate manufacturing. This fundamental dilemma translates to these very typical questions: "Do I purchase pure vitamin C or vitamin C with additives?" "Do I purchase pure B vitamins or coated B vitamins for taste masking?" "Do I purchase pure enzymes such as pancreatin, pepsin, and bromelain or enzymes diluted with lactose?"

There are few commercial sources for vitamins B12, D, K, or biotin that are not diluted with substances such as lactose, cornstarch, and preservatives such as BHT. That's why Thorne developed methods that allow them to use pure, undiluted sources of these nutrients – and many others. It's just one more example that when it comes to quality, what everyone else accepts as an industry standard isn't good enough. While some companies say they are raising their standards....at Thorne they set them.

Suggested Use

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Take 3 capsules two times daily or as recommended by your health-care practitioner.

Store tightly sealed in a cool, dry place.

ALLERGY WARNINGS
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PURITY
This product does not contain wheat, gluten, corn, yeast, soy, egg, dairy products, or artificial colors, artificial sweeteners, or artificial flavors. This product also does not contain lactose, palmitic acid, magnesium stearate, or stearic acid.

PREGNANCY WARNING
If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.


Thorne Research Methyl-Guard - 180 Vegetarian Capsules
Supplement Facts
Serving Size: Three Capsules
Servings Per Container: 60
Amount Per Serving %DV*
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1020%
Folate (as 5-Methyltetrahydrofolate) 1.2 mg 300%
Vitamin B12 (as Methylcobalamin) 1.2 mg 20000%
Betaine (Trimethylglycine) 1.8 g *
*Daily Value Not Established.
**Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
 

Other Ingredients: Hypromellose (derived from cellulose) capsule, CalciumCitrateLaurate, Silicon Dioxide

Hypoallergenic.

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Manufacturer Info

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P.O. Box 25
Dover, ID,
Phone: 800-228-1966 Fax: 800-747-1950 Visit website

About Thorne Research

At Thorne Research, our mission is to enhance the health and well-being of people by providing superior dietary supplements that have the highest level of quality and purity – thereby creating the most respected and valued company in the dietary supplement industry.

*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

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