Thorne Research Perfusia-SR - 120 Vegetarian Capsules
Sustained-release L-arginine supports cardiovascular function, wound healing, and immune function – and is a biological precursor to nitric oxide. L-arginine is a semi-essential amino acid involved in multiple areas of human physiology and metabolism. L-arginine significantly affects endocrine function and helps regulate the release of neurotransmitter chemicals, insulin, glucagon (which has the opposite effect of insulin; i.e., it raises blood sugar), and growth hormone. However, one of L-arginine's most compelling contributions to human physiology is its role as a biological precursor of nitric oxide. The vascular endothelium (lining of the arteries) creates nitric oxide from L-arginine, resulting primarily in blood vessel relaxation. This property is critical to maintaining good vascular health, heart health, reproductive health, and protection against oxidative damage.
When sufficient L-arginine is present:
- arteries relax, promoting optimal blood flow
- as arteries relax, already normal blood pressure can be better maintained
- erections occur in the normal course of intimacy
- supple, flexible arteries are better able to support good cardiovascular health
Maintaining the natural, healthy functions of the vascular endothelium is dependent upon an adequate supply of L-arginine being available to these cells. As mentioned above, the conversion of L-arginine to nitric oxide is responsible for these functions by making the endothelial cells more resistant to oxidative damage and adhesion by otherwise harmful substances. Numerous studies have demonstrated that individuals with sufficient nitric oxide production by endothelial cells have the best opportunity to maintain already normal cardiovascular health.
In a large, double-blind trial that observed male reproductive health issues, 1.6 g L-arginine daily for six weeks resulted in improvement in reproductive health in those men with low nitric oxide metabolism.
Like most amino acids, L-arginine functions as a building block of proteins; however, its presence also appears to support wound healing. Numerous studies show L-arginine supplementation benefits wound healing time and strength of the tissue in and around the wound during the healing phase.
Without adequate L-arginine (and subsequently, nitric oxide) available to vascular endothelial cells, arteries may not optimally dilate, which can result in less than optimal blood flow to the organs and extremities.
L-arginine is absorbed and metabolized by the body very quickly, which usually necessitates taking it frequently throughout the day. Sustained-release Perfusia-SR, however, maintains an optimal level of L-arginine over 24 hours with suggested twice-daily use.
Studies on Perfusia-SR show increased blood flow to the heart muscle and the extremities, maintenance of already normal blood pressure, and improved vascular elasticity. A recent study demonstrated improvements in blood flow after Perfusia-SR supplementation in individuals with less than optimum heart health. In another study, Perfusia-SR was given to 29 healthy volunteers for one week and significant support of their already normal cardiovascular health was observed.
Dr. Michael Lebowitz D.C. Recommends:
Perfusia is a sustained-release L-Arginine product. L-Arginine is converted into nitric oxide in the body and is critical to vascular endothelial health and elasticity. It is also very useful in erectile dysfunction and as a pre-workout supplement to increase performance. Like Omega 3 w/ CoQ10 it tests positive in many cases with a family history of cardiac/circulatory problems. There are two simple in-office tests Dr. Michael Lebowitz performs that in his opinion suggest a tendency toward cardiac and circulatory issues. In one test Dr. Michael Lebowitz has the patient rotate the head fully to one side, and he immediately tests and indicator muscle. If it remains strong, Dr. Michael Lebowitz waits 10 seconds and retests. If the muscle now weakens it is a positive test. Dr. Michael Lebowitz does this test bilaterally. If the patient ingests either Omega 3 w/ CoQ10 of Perfusia, the positive test is often negated and after taking the product for a few weeks the patient in many cases no longer shows a positive test. The other test is to test the subscapularis muscle in the standing position (test both sides). Then have the patient do 10 in-place jumps and redo the test. If the subscapularis weakens it is a positive test. This test is also often negated by Omega3 with CoQ10 or Perfusia or possibly L-Carnitine and should be supplemented accordingly. In cases with strong family cardiac history this product often needs to be given indefinitely.
Thorne Research's Mission
At Thorne Research, their mission is to enhance the health and well-being of people by providing superior dietary supplements that have the highest level of quality and purity – thereby creating the most respected and valued company in the dietary supplement industry.
The Thorne Difference.
For more than 25 years, Thorne has relentlessly pursued the highest possible quality and bioavailability in dietary supplements. At Thorne, they actually manufacture products that they sell – a key difference that allows Thorne to control every aspect of the manufacturing process and ensure that every Thorne product is in pure, completely hypoallergenic form, and without the common additives, flowing agents, and binders used throughout the industry.
A few other companies have tried to do what Thorne does, and many others claim to have the same philosophy and quality, but nobody has been able to duplicate what Thorne's clients call "Thorne Quality." Thorne has changed the industry in many ways over the past two decades, and they continue to raise the bar and set new standards in product formulation, raw material purity, manufacturing, and quality control.
Thorne's Commitment to Purity
Practitioners have become accustomed to seeing the vague "We use only the purest ingredients" in the promotional materials of almost every dietary supplement company. Perhaps these companies truly believe that. Perhaps they don't know any better. Nevertheless, Thorne Research, for more than 25 years, has been the standard by which companies in the industry are judged for product purity. Practitioners rely on Thorne as the company they trust for their extremely allergic, chemically sensitive, and immune-compromised patients.
Purity Takes Extra Effort
For example, instead of purchasing prediluted vitamin D, as other companies do, Thorne performs its own dilution to avoid detrimental ingredients, such as the preservatives or lactose that are found in many commercially available dilutions. Why must vitamin D be diluted? Because in its pure form, it is too concentrated to safely blend into a vitamin product. Pure vitamin D is 40 MILLION International Units (IU) per gram. The RDA for adults is 600-800 IU per day. To ensure proper mixing, it must be made into a dilute powder that flows and does not lose potency. So, unlike companies that use prediluted vitamin D that contains unacceptable excipients and preservatives, at Thorne, pure pharmaceutical vitamin D is first blended with pure mixed tocopherol vitamin E, and the resultant stable vitamin D is then blended with hypoallergenic cellulose powder. The final powder is blended in a large tumble blender and subsequently analyzed. Not only is the final product stable; it is also hypoallergenic and can be mixed homogeneously and at a safe level with other powders. Just as with vitamin D, Thorne utilizes similar processes for other raw materials, such as vitamin K, leaving it to other companies to purchase commercially available raw materials filled with unacceptable ingredients and preservatives.
Ingredients You Don't Want
Magnesium Stearate: Good for speed-hungry encapsulating machines. Not necessarily good for you. Manufacturing encapsulated dietary supplements isn't easy. Pure powdered ingredients are difficult to mix because they are either extremely dry, sticky with botanical oils, or attract unwanted moisture. So most manufacturers add magnesium stearate and other agents such as lactose and dextrose to make the powder flow quickly and easily through their high-volume machines. Problem is, these additives may compromise the bioavailability of the nutrients in the supplement, and might cause allergenic problems. At Thorne, they take a different approach.
Thorne will never utilize large fatty acid excipients in its manufacturing processes – ingredients such as magnesium stearate or stearic acid. These excipients are utilized as flowing agents to ensure that maximum productivity is obtained from capsuling and tableting machines. There are documented detrimental effects directly attributed to long chain fatty acids utilized as manufacturing flowing agents. Every qualified pharmaceutical compounder recognizes that large fatty acids, such as magnesium stearate, can interfere with product dissolution and influence absorption. Virtually all companies, because of the economic impact, ignore this data. As with most industries, the bottom line dictates the level of quality. The dietary supplement industry has one exception: Thorne Research, the company that does not compromise. Nevertheless, if a company cannot manufacture products without using detrimental excipients, they should not allude to being either "hypoallergenic" or "pure."
The Bottom Line?
Thorne is the only hypoallergenic dietary supplement manufacturer with the highest degree of purity that you – and your most severely allergic, chemically sensitive, and immune-compromised patients – can truly trust.
Quality Ingredients: A Higher Standard
At Thorne, they are committed to setting a higher standard of quality when it comes to ingredients. To produce their truly hypoallergenic encapsulated supplements, Thorne uses only the purest and finest ingredients available.
Every manufacturer has two basic options when purchasing raw materials: purchase either truly pure raw materials, or purchase raw materials to which substances have been added to facilitate manufacturing. This fundamental dilemma translates to these very typical questions: "Do I purchase pure vitamin C or vitamin C with additives?" "Do I purchase pure B vitamins or coated B vitamins for taste masking?" "Do I purchase pure enzymes such as pancreatin, pepsin, and bromelain or enzymes diluted with lactose?"
There are few commercial sources for vitamins B12, D, K, or biotin that are not diluted with substances such as lactose, cornstarch, and preservatives such as BHT. That's why Thorne developed methods that allow them to use pure, undiluted sources of these nutrients – and many others. It's just one more example that when it comes to quality, what everyone else accepts as an industry standard isn't good enough. While some companies say they are raising their standards....at Thorne they set them.