Biotics Research Beta Plus - 180 Tablets

Biotics Research Beta Plus is the source of bile salts, digestive enzymes and organic beet concentrate with SOD and catalase.  Consider whenever the gallbladder has been removed or the need for supplemental bile salts is indicated. 

Bile, Defined
Bile functions as the body’s “detergent” emulsification and absorption of lipids, critical for fat digestion and assimilation. Bile is produced by the liver, and is temporarily stored in the gall bladder. Bile is released into the small intestine in response to hormones, such as cholecystokinin, when fat enters the intestine.  Bile consists of a mixture of bile salts, bile acids, cholesterol, bilirubin and phospholipids chiefly phosphatidylcholine. The ratio of individual lipids are critical to maintain a stable micellar concentration. The molar ratios are typically 5:15:80 for cholesterol/ phosphatidylcholine/bile salts. If the bile concentration becomes too high, cholesterol will precipitate and gallstones will form in the gall bladder, a condition known as cholelithiasis.

Bile Formation
Bile salts and acids represent oxidized derivatives of cholesterol. About 80% of the cholesterol in the body will eventually be disposed of as cholic acid. The primary bile acids, cholic acid and chenodeoxycholic acid, possess a carboxylic acid side chain which confers hydrophilic properties to the lipophilic sterol ring and creates detergent-like molecules. The liver attaches taurine and glycine to bile acids to create bile salts (taurocholate or taurochenodeoxycholate and glycocholate or glycodeoxycholate, respectively).  Bacterial enzymes in the colon can convert these to secondary bile acids, deoxycholate and lithocholate.

Bile and Digestion
Bile is needed for efficient uptake of oily nutrients (fats). When bile acids and bile salts first encounter ingested fats, they act as emulsifiers to create suspensions which can be broken down enzymatically. The process involves several important steps; sequentially indicated as:

1. The combined action of bile salts and pancreatic lipase initiates hydrolysis of triglycerides to free fatty acids and diglycerides, resulting in the formation of emulsions containing other lipid-soluble nutrients, including vitamins and carotenoids. The particle size of these emulsions ranges from 200 to 5,000 nm in diameter.
2. Lipase is then able to hydrolyze both di-and triglycerides to monoglycerides and free fatty acids.  Lipase requires a smaller protein called colipase, another pancreatic product, to bind to triglycerides and activate the lipase.
3. Upon further release of bile salts, the lipid aggregates become smaller, from 3 to 10 nm in diameter. The normal endpoint of triglyceride digestion is a product containing 70% free fatty acid anions, 25% beta monoglycerides and 5% cholesterol.

The micelles are then taken up by the epithelial cells of the brush border membrane via passive diffusion. After absorption, the fate of fatty acids depends upon their sizes. Medium chain fatty acids, with less than 10-12 carbons, pass directly from the mucosal cells into the portal blood and bind to serum albumin. Longer chain fatty acid anions are re-esterified with beta monoglycerides in the smooth endoplasmic reticulum to reform triglycerides.  The newly synthesized triglycerides are complexed with apoproteins, cholesterol and phospholipids, to produce particles called chylomicrons.  Chylomicrons are released from mucosal cells by exocytosis and enter the lymph, rather than entering the bloodstream directly.

Enterohepatic Circulation
Bile salts do not cross the mucosal barrier into the lymphatic system but rather they are reabsorbed as micelles in the lower region of the small intestine.  Most of the bile salts released into the intestine are reabsorbed in the lower ileum where bacteria can reduce free bile acids to lithocholate and deoxycholate.  The absorbed bile acids and salts are transported via the portal vein to the liver as complexes with serum albumin. The liver efficiently extracts them, conjugates them with amino acids and again secretes them as bile, which is returned to the gall bladder to continue to aid digestion. Bile salts are recirculated 2-3 times through the liver with each meal.

Betaine
Beets are a concentrated source of Betaine, which functions in the methylation of homocysteine, converting it into methionine and dimethylglycine dimethylglycine.  An elevated level of homocysteine, termed homocysteinemia, is a risk factor for cardiovascular complications. Dimethylglycine, in turn, functions as a methyl donor, thus aiding in both the detoxification and immune pathways. Betaine is often referred to as a “lipotropic factor” as it assists the liver in the processing of fats. Studies with betaine have correlated its use with liver protection.  For example in one study, subjects exposed to carbon tetrachloride (CCl4), were followed with an oral treatment of betaine. They were observed to have a significant reduction in liver necrosis, which was attributed to betaine use. In another study, following CCl4 injection in test animals, supplemental betaine was observed to reduce liver triglycerides as well as centrilobular hepatic lipidosis.

Fiber and the Binding of Bile Components
Certain kinds of dietary fiber bind bile salts.  Examples include pectin (found in fruits and berries), hemicelluloses (found in cereal grains), and certain types of fiber that occur in legumes. When the diet is rich in partially soluble fiber, more bile is excreted (not reabsorbed). As a consequence, blood cholesterol levels may be reduced to account for more bile salt formation, consequently slowing the development of atherosclerosis.

Nutritional Support of Bile Formation Bile.
Bile salts, along with other components, including cholesterol, electrolytes and water are stored in the gallbladder. Bile salts act as an enzyme aide, and serve to enhance the absorption of fatty acids and some fat-soluble vitamins. Bile also serves as a fat emulsifier, thus increasing the surface area of the fat, and allowing it to become water-soluble. Thus bile aids aide in the absorption of fatty acids and cholesterol via the formation of micelles. The micelles, soluble in chime, are then easily absorbed by epithelial cells. Bile also serves in a protective mechanism, functioning to maintain the intestinal barrier against invading microorganisms.

All Bitoics Research Items are Gluten Free!

Currently, it is believed that gluten sensitivity (gluten intolerance) effects almost 700 million people worldwide. Gluten intolerance covers a wide spectrum of conditions, including celiac disease and wheat allergy. Symptoms include bloating, abdominal discomfort, pain, diarrhea, headaches and migraines, lethargy, attention- deficit disorder, muscular disturbances, bone and joint pain, and even schizophrenia.

At Biotics Research, they provide superior nutritional supplements to benefit the patient health. ALL BIOTICS RESEARCH PRODUCTS ARE GLUTEN FREE and they always have been! With Biotics Research, there's no need to search through a catalog for all of the ingredients, or review label after label. You can use any product from Biotics Research without concern because ALL BIOTICS RESEARCH PRODUCTS ARE GLUTEN FREE !

Quality Control - What Sets Biotics Apart

The Biotics Research way!

At Biotics Research Corporation, we manufacture our own branded products on site, in our own state of the art facilities, allowing for complete control of the entire manufacturing process. In our on-site laboratories, the highly skilled members of our Quality Control Unit, utilize modern, sophisticated technologies and validated analytical methods to test incoming raw materials, monitor manufacturing processes, perform in- process testing, and test all finished products prior to their release for shipment. In fact, many aspects of our cGMPs (current Good Manufacturing Practices) exceed the new, recently enacted FDA guidelines for dietary supplements in order to ensure the safety and effectiveness of our products.
The Quality Control Unit (QCU) has the authority to approve and/or reject all specifications and procedures associated with the production and release of all raw materials, packaging materials and finished products, including test methods and results, instrument calibrations, and processing records. The QCU conducts all internal audits, and validates and audits all raw material and packaging suppliers and service vendors as well.

All incoming raw materials are subject to appropriate testing prior to their release for production. Tests conducted include identity, potency, biological activity, microbiological, including bacteria, yeast and mold (including aflatoxins) and heavy metals (arsenic, cadmium, lead & mercury). Retained samples are maintained of all raw materials and finished products for future testing requirements (raw material stability and finished product expiration date verification).

All bulk finished products (tablets & capsules) are inspected and subjected to metal detection prior to being sampled by QC. They are then subject to appropriate disintegration and/or dissolution testing, and potency testing prior to being released to packaging. All liquid and powder products are tested for potency prior to packaging as well. Finally, microbiological testing is performed on all finished products and document reconciliation is completed prior to being released for shipment.

All testing is performed by our trained QC personnel using state of the art laboratory instrumentation including High Pressure Liquid Chromatography (HPLC), ICP, Atomic Absorption Spectrophotometry (AA), gel electrophoresis, FT -IR, Ultra Violet spectrophotometry, Thin Layer chromatography and Gas Chromatography-Mass Spectrometry (GC- MS).

Unlike many companies that are struggling to meet the new GMP requirements established by the FDA, companies that are being regulated into implementing quality programs, extensive Quality Control has always been part of the corporate fabric of Biotics Research Corporation.

From day one, the mantra of Biotics Research Corporation has been “Innovation and Quality.” Our goals remain unchanged – utilize innovative ideas and carefully researched concepts with advanced techniques to develop products of superior quality and effectiveness – bringing you “The Best of Science and Nature”.