Douglas Laboratories Pterostilbene Supreme - 30 Vegetarian Capsules
Douglas Laboratories Pterostilbene Supreme provides pterostilbene, a methylated resveratrol that is naturally occurring in berries. This formula also contains resveratrol, curcumin and vitamin D3 which can function synergistically with pterostilbene to support healthy aging. Pterostilbene, a methylated form of resveratrol is considered the next generation of resveratrol. Pterostilbene has advantages over resveratrol: superior biological activity, better oral bioavailability, and slower metabolism in the body.
pTeroPure pterostilbene is a nature identical form of trans-pterostilbene, a stilbene found in certain berries. The enhanced activity of pterostilbene compared to resveratrol may, in part, be explained by structural differences. Pterostilbene with two methoxy groups and one hydroxyl group has greater lipophilicity and a higher potential for cellular uptake than resveratrol, which has three hydroxyl groups. Pterostilbene showed strong inhibitory activity, much more than resveratrol, against a particular form of cytochrome P450. Researchers have suggested that these two compounds also work synergistically, supporting the theory that a combination of pterostilbene and resveratrol in a formulation may be more effective than using these ingredients separately. Both pterostilbene and resveratrol support mitochondrial function and healthy aging by activating SIRT1, one of the key enzymes of the sirtuin family. Sirtuins, a class of proteins, have been implicated in influencing aging and regulating transcription, apoptosis and stress resistance, as well as energy efficiency and alertness during low-calorie situations.
Pterostilbene also supports cardiovascular health; results from in vitro studies showed that pterostilbene acts as a PPARR agonist and may be a more effective PPARR agonist and hypolipidemic agent than resveratrol. In vivo studies demonstrate that pterostilbene possesses lipid and glucose lowering effects. Pterostilbene Supreme also contains Resvida, a pure resveratrol clinically studied for its safety. Resvida resveratrol is unique as it is not a plant extract and is not derived from plant sources, therefore presents no risk for contamination with pesticides and other potentially unwanted compounds. Studies indicate resveratrol may be supportive in maintaining the normal aging process by helping to prevent free radical damage that can lead to premature aging of cells.
Studies have shown that curcumin, a naturally occurring group of compounds from turmeric, function as powerful antioxidants and can help support neurological and cardiovascular function. Since curcumin exhibits poor oral absorption in the body, Douglas Labs has chosen a highly bioavailable curcumin called MERIVA. Pharmacokinetic comparison studies have shown MERIVA to have up to a 20-fold improvement in bioavailability versus the standard 95% turmeric extracts due to proprietary PHYTOSOME technology which increases hydrolytic stability. Vitamin D, curcumin and resveratrol/pterostilbene share many common targets and points of overlap in gene regulation, signal transduction and therapeutic effects. The nature of this overlap suggests synergy upon combination, potentially leading to an influence on inflammatory and cardio-protective pathways.
Japanese wasabi with a specially standardized broccoli sprout concentrate and organic pomegranate extract are added to this formula to support the body’s natural antioxidant and detoxification processes. Sulforaphane, an ITC found in broccoli, has been found to significantly increase the activity of detoxification enzymes (cytochrome P450). Pterostilbene Supreme may be a useful supplement for individuals wishing to consume a powerful combination of antioxidants and vitamin D for cardiovascular health or longevity support.
Trust Douglas Laboratories, The Choice Of Thousands Of Healthcare Practitioners For Over 50 Years.
Trust Douglas Laboratories for a partnership founded on a heritage of excellence. For more than 50 years, they have been at the forefront of the nutritional health industry, proudly researching, developing and manufacturing superior-quality, science-based dietary supplements to help people improve their health. Proudly earning the trust of thousands of healthcare professionals.
Trust Douglas Laboratories for best-in-class, science-based dietary supplements manufactured exclusively for healthcare professionals. They are proud to offer one of the largest and most innovative selections of over 600 premium-quality products and a comprehensive range of galenic forms (dosage and delivery), manufactured at GMP-compliant, state-of-the-art facilities.
Trust Douglas Laboratories for personalized, one-to-one consultation on the latest, most reliable science, for strategies on using nutritional health to complement your practice and for coaching to better advise your patients on the right supplements for them.
About Douglas Laboratories
Back in 1955, Sam Lioon, founded Douglas Laboratories on a simple promise: provide the highest quality nutritional supplements available with the highest level of personal service—anywhere. And with that promise began a legacy of leadership—and a never-ending quest to exceed their customers’ expectations to Raise the Standard for Nutrition and Wellness.
Today that legacy lives on as Douglas Laboratories proudly joins the Atrium Innovations group of companies. Atrium Innovations is an international company and global leader in the development, manufacturing, and marketing of dietary supplements, specialty fine chemicals, and active cosmetic ingredients.
Douglas Laboratories is supported by more than 300 Douglas Laboratories employees all dedicated to keeping the promise Sam made 50 years ago. Raising the Standard is more than a slogan—it’s a promise. As they enter their second half-century, Douglas Laboratories will continue to keep their promise to Raise the Standard with a custom approach to ytheir patients’ nutrition and wellness. With custom formulations ytheir patients can’t find anywhere else. Custom labels. Custom daily packs. And the industry’s largest and most innovative product line. And they’ll back up their promise with the kind of stringent criteria many other companies overlook, such as:
(cGMPs) current good manufacturing practices.
ISO 9001 Certification and ISO 17025 Accreditation of their laboratories.
The industry’s first fully electronic, bar code driven, paperless manufacturing system to pass the FDA’s rigorous audit. Their exclusive Veri-Match labeling system, ensures verification prior to production and release of ytheir products.
(SOPs) standard operating procedures.
VCP (Vendor Certification Program) ensures raw material safety and quality.
Experienced, on-staff Ph.D’s, utilizing three full-service laboratories, outfitted with the latest analytical equipment.
State-of-the-art manufacturing, including ultra high-speed encapsulating machines, capable of producing over 35 million capsules and tablets daily!
Full compliance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002, assuring safety and uninterrupted flow of all raw materials.
Douglas Laboratories continues to lead the way with clinical trials designed to validate the efficacy of their products. Their world-renowned Ultra-Preventive X (Ten) was rated the #1 multivitamin in the professional healthcare market, and their Vita-Big-Kids was rated the #1 children’s multivitamin overall by the independent Comparative Guide to Nutritional Supplements. Their commitment to help support patient outcomes is ongoing; look for their new in-office patient education posters, easy online ordering from their website and more innovative ideas designed to help ytheir practice grow in the days ahead.
But most of all, they’re proud of the many long-standing relationships they’ve enjoyed with so many customers over the years, and the many great friendships they’ve made along the way. It’s not an exaggeration to say that they truly enjoy what they do, enjoy coming to work each and every day.