Species Nutrition - Lipolyze Evolved Advanced Fat Loss Formula - 90 Capsules
Species Nutrition Lipolyze Advanced Fat Loss Formula can be best categorized as a caloric wasting compound . Whereas most fat burning formulations on today's market depend on stimulants such as ephedra (rarely seen today), caffeine, and synephrine at SPECIES, they reject the premise that the only effective way to burn fat is to "stimulate" the body into submission. While stimulants do increase metabolic rate, they also increase the production of catabolic (muscle wasting) hormones such as cortisol. As cortisol levels rise in the body, lean muscle tissue is broken down, immune system function is suppressed and dangerous abdominal belly fat deposition is increased.
Remember, the quantity of lean muscle in the body is highly correlated with the basal metabolic rate (BMR). Less muscle means a lower BMR! If stimulant-based fat burners are used to help shed unwanted body fat, there's a very good chance that, once they're discontinued, metabolic rate will be significantly lower and the predisposition to gain unwanted body fat will be significantly higher. If this scenario wasn't bad enough, consider this stimulants raise blood pressure, increase heart rate, and increase anxiety levels. Therefore, individuals with a history of heart disease, high blood pressure, or brain chemistry abnormalities should certainly steer clear of these compounds.
In the following paragraphs, they will explain how five unique herbal compounds work in synergism to create the extremely potent, non-stimulant based, fat burner that we find in LIPOLYZE.
OEA is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-á) agonist synthesized in the intestines. PPAR-á is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (storage of fatty acids).
OEA has also been shown to have anorexic properties, meaning it decreases food intake and sends hunger-curbing messages to the brain.
If all that weren't enough, OEA can also lower blood cholesterol and triglyceride levels.
T2 (3,5 di-iodo-thyronine)
T2 is a metabolite of the thyroid hormones T4 (thyroxine) & T3 (triiodothyronine). It has specific direct actions which do not involve thyroid hormone receptors, unlike T4 and T3.
(1) It raises BMR (basal metabolic rate) which in turn increases energy expenditure in the body.
(2) It's a metabolic uncoupling agent that "uncouples" or disconnects the ATP-producing machinery in the cell and "releases" all the potential energy that was supposed to be used to produce ATP. Due to the energy and ATP loss (which is dissipated as heat), the muscle cells must dig into stored body fat stores and oxidize additional fats to ensure that optimal energy levels are maintained.
The following analogy should help explain how T2 exerts its energy-wasting effect in the human body. Imagine someone putting a hole in the gas tank of your automobile. The car would still perform at maximal capacity however, it would require a significant amount of additional fuel to travel the same distance it had prior to the punctured tank. Likewise, T2 makes the mitochondrial membranes more permeable (creates openings) which cause the loss of valuable "fuel" (ATP) from the "tank" (muscle cell). To combat this energy loss, additional fatty acids must be oxidized to ensure optimal performance levels.
Even more exciting is that fact that T2 "wastes" calories without elevating blood pressure, without raising heart rate, and without causing central nervous system over-stimulation.
(3)T2 stimulates the conversion of T4 (inactive thyroid hormone) into the more active T3 form.
(4)T2 stimulates the release of growth hormone (GH) which is a powerful fat burning and tissue regenerating compound.
Inside the cell, L-carnitine transports long chain fats into the mitochondria (energy-producing chamber) where they are then oxidized into ATP. In theory, if we can increase the amount of L-carnitine within the muscle, we can theoretically increase the quantity of fatty acids that get oxidized. Until recently the problem has been that regular L-carnitine and even the more exotic acetyl-L-carnitine lacked the ability to penetrate skeletal muscle tissue (which is where most fat oxidation occurs).
On the other hand, Propionyl-L-carnitine, a relatively new version of L-carnitine, has important effects on skeletal and cardiac muscle. Back in 1990, a human study demonstrated that propionyl-L-carnitine could combat the destructive effects of low oxygen status and muscle fatigue in heart and skeletal muscle. More relevant to our discussion is the fact that propionyl-L-carnitine has a tremendous ability to penetrate skeletal muscle and thus facilitate the transport of long chain fatty acids into the mitochondria.
The thyroid gland releases a hormone known commonly as thyroxin (T4 for short). T4 is an inactive form of thyroid hormone that must ultimately be converted into triiodothyronine (T3), the active thyroid hormone. Whenever any sort of diet is initiated, the body's natural inclination is to slow down the conversion of T4 (inactive) to T3 (active). Ultimately, when this happens, metabolic rate slows and fat losses crawl to a halt.
In India, the Guggul is a tree which exudes a resinous sap out of incisions that are made in its bark. This resin has been used for centuries as part of Indias traditional medicine called Ayurveda. This resinous sap can be processed, purified, and then standardized for its active components Guggulsterones Z and Guggulsterones E. These two fractionations have the unique ability to support thyroid function by increasing the conversion of inactive T4 into active T3 and, in doing so, restore normal thyroid function to the dieting athlete.
GREEN TEA EXTRACT
Green Tea Extract (Camellia sinesis leaf) is a powerful antioxidant similar to vitamin C, vitamin E, and beta-carotene. However, researchers have suggested that the active ingredient called epigallocatechin gallate (EGCG) may, amazingly, have 200 times the antioxidant properties of vitamin E. A study from the American Journal of Clinical Nutrition revealed that green tea extract caused a significant increase in energy expenditure and fatty acid oxidation. The researchers noted a 4% increase in 24-hour energy expenditure which actually translates to a 35-43% increase in daytime thermogenesis. What's even more significant to cardiac and thyroid patients is the fact that none of the research subjects reported any of the side effects rapid heart rate, elevated blood pressure, or increased anxiety that are commonly seen with the multitude of stimulant-based fat burners.
What sets LIPOLYZE apart from the thousands of other fat burners?
LIPOLYZE can be best categorized as a caloric wasting supplement. Whereas most fat-burning formulations on today's market depend on stimulants such as ephedra (rarely seen today), caffeine, and synephrine at SPECIES, we reject the premise that the only effective way to burn fat is to "stimulate" the body into action. While stimulants do increase metabolic rate, they also increase the production of catabolic (muscle-wasting) hormones such as cortisol. As cortisol levels rise in the body, lean muscle tissue is broken down, immune system function is suppressed, and dangerous abdominal belly fat deposition is increased. Remember, the quantity of lean muscle in the body is highly correlated with the basal metabolic rate (BMR). Less muscle means a lower BMR! If stimulant-based fat burners are used to help shed unwanted body fat, there's a very good chance that, once they're discontinued, metabolic rate will significantly decrease and the predisposition to gain unwanted body fat will significantly increase. If this scenario wasn't bad enough, consider the fact that stimulants raise blood pressure, increase heart rate, and increase anxiety levels.Â What this means is that individuals with a history of heart disease, high blood pressure, or brain chemistry abnormalities should certainly steer clear of these compounds. LIPOLYZE is the most potent non-stimulant based fat burner that's legally available today!
What is USNIC ACID and how does it work?
Usnic acid, the key ingredient in LIPOLYZE, is what's known in the field of biochemistry as an uncoupling agent. Usnic acid, which is derived from a simple plant lichen, essentially "uncouples" or disconnects the ATP-producing machinery and thus releases all the potential energy that was supposed to be used to produce ATP. Due to all the energy and ATP loss (which is dissipated as heat), the muscle cells must dig into stored body fat and oxidize additional fats to ensure that optimal energy levels are maintained within the cells.
The following analogy should help explain how Usnic acid exerts its energy wasting effect in the human body. Imagine someone putting a hole in the gas tank of your automobile. The car would still perform at maximal capacity; however, it would require a significant amount of additional fuel to travel the same distance it had before the punctured tank. Likewise, Usnic acid creates temporary "holes" in the mitochondrial membrane which then results in the loss of valuable "fuel" (ATP) from the "tank" (muscle cell). To combat this energy loss, additional fatty acids must be oxidized to ensure optimal performance levels.
Even more exciting is that fact that Usnic acid "wastes" calories without elevating blood pressure, without raising heart rate, and without causing any central nervous system stimulation. An individual can, literally, swallow a dose of Usnic acid, fall asleep, and start burning fat; even while unconscious.
Individuals who consume 36mg of Usnic acid per day usually notice a slight increase in body temperature. This phenomenon is due to the fact that lost energy escapes from the body as heat. Remember, warmth is a good indicator that the Usnic acid is effectively wasting energy and thus burning fat.
Do I have to take LIPOLYZE and SOMALYZE together? Couldn't I just add one LIPOLYZE before bed?
SOMALYZE has many benefits that apply specifically to fat burning at night. First of all, SOMALYZE is a great anti-anxiety and sleep aid. We all know the importance of sleep and recovery, especially for someone trying to lose weight. As your quality of sleep increases, your ability to recover from stress and strenuous exercise also increases. Recent research has also demonstrated that well-rested individuals have much higher levels of appetite-suppressing leptins in the body. Therefore, the more you sleep, the less you'll feel like eating.
Secondly, some of the ingredients in SOMALYZE have been, experimentally, shown to increase natural growth hormone (GH) release during sleep. Increased nocturnal growth hormone (GH) speeds muscle recovery and reduces stored body fat reserves.
Finally, in addition to the unique sleep-inducing ingredients in SOMALYZE, it also contains the same potent, non-stimulant, fat burning agents found in LIPOLYZE.
When acting in synergism, LIPOLYZE and SOMALYZE are a deadly duo for fat loss, muscle recovery, and a good night's sleep.
I read a story about a woman who claims that after taking 500mg per day of Usnic Acid, her liver "shriveled up and died". I think the title of the newspaper article was entitled, "She lost her liver trying to lose weight"? I remember reading an MD interview with Dave Palumbo where the interviewer brought up a similar story and Dave responded by saying that if someone took a huge amount of Valium, or even Vitamin C, they would screw up their liver, too. Insane as this may sound, if someone actually took enough LIPOLYZE or SOMALYZE to equal 500mg per day [36 pills], would it damage their liver like in the above story?
Usnic acid causes cellular energy-wasting by allowing potential energy that could be used to synthesize ATP to leak out of the cells via "leaky" mitochondrial membranes. Because of this energy loss, the cells must compensate by oxidizing additional fatty acids in order to ensure that adequate ATP levels are maintained. Whenever fatty acid oxidation in increased, the production of free radicals is also increased; and too many free radicals can potentially damage the cells integrity. This is where antioxidants come into play.
Several in vitro (cell culture) studies have demonstrated that massive amounts of Usnic acid can damage liver cells. Remember, this data has only been observed in petri dish conditions; not in the living organism. It should also be remembered that cells grown in petri dishes have one distinct disadvantage over cells found in the living body; there are no antioxidant systems to protect against free radical-induced oxidative damage. With this fact in mind, these same studies revealed that by adding a simple antioxidant like vitamin E to the cell culture media, cell damage was drastically reduced (if not eliminated).
The human body has a large array of endogenous antioxidant systems such as superoxide dismutase, glutathione reductase, catalase, and various peroxidases that effectively neutralize most free radicals that can lead to oxidative stress. Additionally, LIPOLYZE and SOMALYZE are both fortified with green tea extract and Vitamin E which further serve to reduce the threat of antioxidant damage within the cells.
I was reading how LIPOLYZE and SOMALYZE waste energy (ATP) inside the muscle cells. Wouldn't that meant that there's less ATP available for workouts?
These Usnic acid-based supplements only uncouple the oxidative phosphorylation reactions that occur in the mitochondria where fats are oxidized. If you remember your biochemistry, anaerobic respiration (without oxygen) takes place in the cytoplasm of the cell (not the mitochondria). It uses glucose (without oxygen) and produces ATP and lactic acid. Wasting ATP in the mitochondria, has nothing to do with ATP production in the cytoplasm that's used for weight training!