Delta-Fraction Tocotrienols by Nutricology
Nutricology Delta-Fraction Tocotrienols 50 mg. 75 Softgels
Nutricology Delta-Fraction Tocotrienols 50 mg. contains tocotrienols from annatto beans and is free of tocopherols. Tocotrienols have more powerful antioxidant activity than tocopherols, and delta-tocotrienol is the strongest of the four tocotrienols. Delta-Fraction Tocotrienols contains delta- and gamma-tocotrienols. Along with tocopherols, tocotrienols are part of the vitamin E family. They are important oil-soluble antioxidants, crucial to the protection of fats, oils, and cell membranes against free radical damage. Free radicals are reactive oxygen compounds generated by our normal biological processes and by exposure to ultraviolet radiation, pollution, cigarette smoke and other environmental and biological stress factors. High levels of free radicals can break down cell membranes and damage cell DNA.
Tocotrienols have been shown to strengthen arterial walls, and to support blood flow through arteries (coronary, carotid, and peripheral). Tocotrienols help prevent the oxidation of LDL cholesterol, and some studies suggest that tocotrienols may prevent cholesterol oxidation more effectively than tocopherols. Unlike tocopherols, delta- and gamma-tocotrienols also support healthy levels of cholesterol, including total and LDL cholesterol. Tocotrienols have an inhibitory effect on HMG-CoA reductase, the liver enzyme that is critical to the rate at which cholesterol is synthesized. Tocotrienols may potentially support endothelial functions and overall cardiovascular health in other ways, including supporting healthy levels of thromboxane, adhesion molecules, and C-reactive protein (CRP), and healthy platelet aggregation. Tocotrienols do not lower plasma coenzyme Q10 as do the statin drugs, but instead increase it.
Preliminary research suggests that delta-tocotrienol has potential to support healthy metabolism by enhancing insulin function, including insulin sensitivity. Research also suggests that tocotrienols may offer some protection from the sun's ultraviolet radiation, working synergistically with tocopherols and helping preserve tocopherols in skin cells.
A small structural difference between tocopherols and tocotrienols results in distinct functional differences in their antioxidant activities, probably due to differences in how each is incorporated into cellular membranes. Tocopherols, with a saturated side chain that interacts hydrophobically with acyl side chains of membrane phospholipids, are relatively less able to access lipid radicals due to steric hindrance. Tocotrienols, with an unsaturated farnesyl side chain, have increased accessibility to lipid radicals and resulting greater antioxidant capacity. Tocopherols also have a significantly longer tail, so they anchor deeply into lipid membranes, whereas tocotrienols anchor less deeply, allowing them to cross more easily from one membrane to the next. These factors may explain why tocotrienol is 40-60 times more powerful as an antioxidant than tocopherol.
Tocotrienols occur in many of the same sources as tocopherols, such as oil from rice bran, palm fruit, barley, and wheat germ, and both tocopherols and tocotrienols occur in alpha, beta, gamma, and delta fractions. Palm and rice contain large amounts of tocopherols and only minor amounts of active delta-tocotrienol, so Delta-Fraction Tocotrienols utilizes tocotrienols extracted from annatto. Annatto produces a superior form of tocotrienols, high in the most beneficial fractions, delta-tocotrienol and gamma-tocotrienol, and is free of tocopherols.
Tocotrienols are well tolerated, with an extensive history of study and safe use. Human consumption of 240 mg/day of tocotrienols for up to two years caused no adverse effects, and animal toxicity studies suggest that they are safe at much higher levels.
Quality and Innovation - The NutriCology Tradition
For more than thirty years, NutriCology has been known for the highest quality, most hypoallergenic, and most cutting-edge nutritional supplements available. Physicians and healthcare practitioners around the world depend on NutriCology for their patients' nutritional support. Originating with the ground-breaking oxidant/antioxidant work of Stephen Levine, Ph.D., NutriCology was one of the first to introduce truly hypoallergenic products to the market.
Superior Quality Control
Since 1979, NutriCology has used only the purest raw materials available, and has implemented strict quality control procedures in every stage of production, including inspection of raw materials, manufacturing, packaging, and storing. NutriCology is licensed by the California Department of Health Services, Food and Drug Branch, registration number 0021150.
Nutricology products are manufactured under the recognized principles of current Good Manufacturing Practice (cGMP), brought into final form by the FDA in June 2007. The GMP standards are applied to a wide variety of procedures associated with the manufacturing of dietary supplements, including receiving, testing, and approval of raw materials, production, and process controls, laboratory testing of labeled and packaged finished product, distribution control and accountability, and shelf life expiration testing to ensure freshness and potency.
For many years they have used the same manufacturers to produce their powder formulas, capsules, tablets, softgels, gels, and liquid products to ensure consistency. All of Nutricology's certified manufacturers meet or exceed cGMP requirements established by the FDA, as well as state and local regulations. In their facility in Alameda, California, highly trained staff bottle, label, and ship finished products. Their newly installed automatic bottling line has multiple built-in quality checks, such as weight verification and metal detection, to ensure all finished packaged products have the pre-determined physical count and are contaminant-free.
Unsurpassed Ingredient Quality
NutriCology uses only the purest and highest quality raw materials available. For example, they use only Nattokinase NSK-SD, the first nattokinase introduced into the US market, which has established standardization and quality levels for all other nattokinase. Their MicroChitosan contains small-size chitosan oligosaccharide, and Prima Uña de Gato contains TOA-free Cat's Claw.
Taber's Medical Dictionary defines "hypoallergenic" as: "Diminished potential for causing an allergic reaction". Nutricology defines hypoallergenic as "free of all common allergens", specifically, wheat, corn, soy, gluten, yeast, dairy, eggs, fish, crustacean shellfish, tree nuts, and peanuts. Many very sensitive individuals who react to supplements in general are able to tolerate NutriCology products.
Since their inception in 1979, Nutricology has used only the purest, and whenever possible, the lowest allergy potential natural ingredients. And while many of the nutrients in their formulas are synthesized from natural plant substances, which as a whole may contain antigens, the synthesizing process removes the molecules of the desired nutrient from the original substance, and in the processing, a great percentage of the antigens and allergens are left behind. The final material then has extremely low allergy potential. This is not to say that no one will react to any of these hypoallergenic formulas, as some extremely sensitive people may. However, the potential for an allergic reaction is low, and the feedback from many extremely allergic and sensitive customers is that NutriCology supplements are often the only products they are able to tolerate.
The FDA requires manufacturers to identify the presence of eight major food allergens on all product labels: milk, egg, fish, Crustacean shellfish, tree nuts, peanuts, wheat, and soybeans, as well as any ingredient derived from those foods. When an ingredient may have been derived from a common allergen, we are required by law to list that allergen on the label as a source of the ingredient, even if it does not contain any of the actual substance. For example, 100%-pure glucosamine sulfate does not contain any actual shellfish, but we are required to indicate the source material (shrimp, crab, lobster) on the label. NutriCology fully discloses all ingredients, both active and inactive on every product label, so doctors can make fully informed choices for their patients' nutritional support.