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About Doctor's Best

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

Contact Doctor's Best

197 Avenida La Pata
San Clemente, CA, 92673
http://www.drbvitamins.com
949-498-3628

Doctor's Best - Best L-Tryptophan Enhanced with B6 & Niacinamide 500 mg. - 90 Vegetarian Capsules (Formerly Best L-Tryptophan TryptoPure)

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Doctors Best - Best L-Tryptophan Enhanced with B6 & Niacinamide 90 Vegetarian Capsules

Doctors Best Best L-Tryptophan products contain Ajinomoto TryptoPure. Tryptophan is an essential amino acid readily converted by the body to the neurotransmitter serotonin. Able to cross the blood-brain barrier, L-tryptophan is altered by enzymes to first form the intermediate amino acid 5-HTP and then serotonin. It is also the metabolic precursor to melatonin and to the B vitamin niacin. Supplementing the diet with pure L-tryptophan like TryptoPure, found in Doctor’s Best L-Tryptophan products, can improve sleep and enhance mood, and may also be beneficial in reducing carbohydrate cravings.

Best L-Tryptophan products contain Ajinomoto TryptoPure. Tryptophan is an essential amino acid readily converted by the body to the neurotransmitter serotonin. Able to cross the blood-brain barrier, L-tryptophan is altered by enzymes to first form the intermediate amino acid 5-HTP and then serotonin. It is also the metabolic precursor to melatonin and to the B vitamin niacin. Supplementing the diet with pure L-tryptophan like TryptoPure, found in Doctor’s Best LTryptophan products, can improve sleep and enhance mood, and may also be beneficial in reducing carbohydrate cravings.

What is Ajinomoto TryptoPure?
TryptoPure is pure, pharmaceutical-grade L-tryptophan produced by the world's leading maker of amino acids—Ajinomoto. The global leader in the research,production, and sales of amino acids, Ajinomoto was one of the first to make pharmaceutical-grade amino acids; they literally invented the process.

Ajinomoto TryptoPure is considered the purest, most trusted L-tryptophan available. It is manufactured via fermentation strictly from vegetable sources, not animal, and it is between 99% and 100% pure. The level of impurities in tryptophan from other makers can be much higher.

In fact, from 1989 to 2006 the FDA was so concerned about the quality of tryptophan coming into the U.S. that it instituted an import ban with one exception: Ajinomoto's TryptoPure. In 1989, the importation of L-tryptophan was banned in the United States after cases of an autoimmune illness called eosinophilia-myalgia syndrome were traced to an improperly prepared batch of tryptophan.The FDA limited L-tryptophan availability to prescription drugs, infant formulas, and enteral feeding products. Because the FDA recognized the unsurpassed quality of Ajinomoto’s TryptoPure, it was excepted from the ban, but its use was limited to those few products. Today, it is available over-thecounter in Doctor’s Best L-Tryptophan products.

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Promotes Normal, Healthy, Restful Sleep
Adequate sleep is a necessity for maintaining proper health. Sleeping well enhances our ability to function during the day. The body requires sleep as downtime to regenerate and repair essential bodily functions and allow us to feel refreshed. L-Tryptophan is a potent nutrient that has been found to enhance restful, peaceful sleep via a number of mechanisms. L-tryptophan is best known for its ability to decrease the amount of time it takes to fall asleep. It has also been shown in studies to enhance total sleep time, decrease intermittent wakening, and decrease early morning wakefulness, allowing the body to feel rejuvenated.

The clinical efficacy of L-tryptophan is due to its ability to support normal production of serotonin in the brain. Serotonin has been implicated in the regulation of sleep, mood, appetite, and temperature, among other roles that it plays in the body. In a review article summarizing findings from over fifty studies conducted between 1970 and 1985, researchers concluded that L-tryptophan enhances overall sleep quality and also effectively provides a remedy for occasional sleeplessness. It does this without dangerous side effects and without any feelings of next-day drowsiness.

Enhances Mood and Sensations of Well-Being
Clinical studies show that L-tryptophan supplementation can positively affect mood and emotional well-being. A randomized, double blind, placebo-controlled trial of 115 individuals found that the administration of L-tryptophan was significantly more effective than placebo for enhancing mood and affect . The subjects took 1 gram of L-tryptophan or an identical placebo capsule three times per day for 12 weeks. Mood and affect were assessed using a standardized, clinically recognized rating scale. Scores in the group supplementing with L-tryptophan were significantly better than placebo at the end of the trial period, indicating L-tryptophan’s success at supporting healthy mood.

Further studies suggest that in healthy individuals, L-tryptophan has positive effects on mood, behavior, and emotional processing. For example, in a recent study of healthy females with normal moods and no history of depression, L-tryptophan supplementation alters the processing and perception of emotional stimuli towards a more positive bias. Supplementation with one gram three times per day caused an increase in happy facial expressions, a decrease in negative and disgusted facial expressions, and a decrease in the attention paid to negative words. A second study conducted in 2006 with a double blind crossover design indicated that the same dose of L-tryptophan (1 gram three times per day) significantly decreased quarrelsome and aggressive behaviors while enhancing agreeable behaviors in everyday social interactions. In this study, participants reported more positive and less negative emotions and rated their interactions as more pleasant.

A number of other studies point to the ability of L-tryptophan supplementation to balance mood. A study published in 1990 suggested that individuals with seasonal variations in mood responded well to supplementation with L-tryptophan. Furthermore, compared to standard light therapy, the mood enhancement associated with L-tryptophan supplementation lasts longer after discontinuation than the effects seen after stopping light therapy.

An additional double blind placebo-controlled study found that two grams of L-tryptophan administered three times a day, from the day of ovulation to the third day of menstruation (the luteal phase) in healthy women, significantly relieved the most prominent mood symptoms associated with PMS. After three months of use, women taking L-tryptophan experienced statistically significant control of extreme mood swings, sadness, irritability, and tension. It also improved their perceived quality of life.

Decreased Carbohydrate Cravings to Support Weight Management Efforts
L-tryptophan may play a supportive role in helping individuals who are currently involved in weight management programs and diets by helping to reduce carbohydrate cravings. During dieting, serotonin levels drop dramatically.Serotonin plays a role in controlling appetite, and eating carbohydrate-rich foods increases serotonin levels in the brain. This may explain carbohydrate cravings and resultant binge eating in some dieters. While no human trials have examined L-tryptophan supplementation directly, a number of clinical trials have used supplemental 5-HTP, the amino acid produced in the body from L-tryptophan. Results of these trials have shown decreases in overall food intake and a subsequent reduction in weight in individuals taking 5-HTP. The majority (75%) of the decreased food intake was from carbohydrates, suggesting decreased cravings for carbohydrates in individuals on 5-HTP. It is likely that L-tryptophan supplementation would have similar effects.

Suggested Use
1 or 2 capsules daily.For optimum absorption, take separately from protein-containing foods and dietary supplements containing protein or amino acids.

Warnings

Uncontaminated L-tryptophan has a thirty-year history of safety and absence of adverse effects at levels commonly consumed by humans. When administered in abnormally high dosages of 7 grams (for a 150 pound human) per day, potential side effects include gastric irritation, vomiting, and head twitching. Use during pregnancy or lactation has not been studied as of yet and is, therefore, not recommended. L-tryptophan should not be used by individuals taking antidepressant drugs without close medical supervision.
Ingredients

Tryptophan Enhanced with B6 & Niacinamide - 90 Vegetarian Capsules (Formerly Best L-Tryptophan TryptoPure)
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 90 Servings
Amount Per Serving %DV*
Niacin (as niacinamide) 20 mg 100%
Vitamin B6
(from 17.6 mg pyridoxal 5-phosphate)
10 mg 500%
Ajinomoto L-Tryptophan 500 mg *
*Daily Value Not Established.
†Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
Other Ingredients: Vegetable capsule, cellulose, magnesium stearate (vegetable source), silicon dioxide.
About Doctor's Best

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.


197 Avenida La Pata
San Clemente, CA, 92673
Phone: 949-498-3628
Fax: 949-498-3952
http://www.drbvitamins.com
Reviews
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Disclaimer: The views and opinions expressed by contributors of the product reviews are their own and not necessarily those of LuckyVitamin.com. LuckyVitamin.com does not endorse or imply any medical claims from these reviews. These reviews should not be taken as recommendations but rather customer opinions of the products that they may or may not have used. Reviews are not intended as a substitute for appropriate medical care or advice and are not intended to diagnose, treat, cure, or prevent any disease. Read the full product reviews disclaimer here.

Average Customer Rating: (5 out of 5)

Based on 4 rating(s)
4 of 4 (100%) of customers said they would recommend this product to a friend.
  • By charlotte ( Bismarck, ND)
    11/17/2011 3:32:06 PM

    I recommend this product!
    great
  • By VATI ( Worthington, MA)
    12/23/2011 8:38:08 PM

    I recommend this product!
    My husband uses this and any night that he takes it according to the directions, he sleeps more soundly and feel more rested in the morning. I think it also improves his mood in winter.
  • By Brenda ( Colorado Springs, CO)
    2/21/2012 5:17:41 PM

    I recommend this product!
    Arrived in a timely manner
  • By Joe ( Lancaster, NY)
    3/29/2012 10:23:01 AM

    I recommend this product!
    You will sleep well, i recommend you take it 2 to 3 hours before bed though.
*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

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