Doctor's Best - Celadrin 500 mg. - 90 Softgels
Doctors Best Celadrin is a proprietary blend of esterified fatty acids that have been shown to benefit joint function and flexibility. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, enhancing membrane permeability and cell-to-cell signaling.
- Supports Range of Motion in Joints
- Maintains Joint Comfort
Celadrin is made from a patented, unique blend of cetylated fatty acids developed through a proprietary process of esterifying oils. Fatty acids such as those in Celadrin are thought to work by influencing cell membrane fluidity and signal transduction pathways and aspects of the immune system (enzymes, cytokines, and cells) involved in joint health. Before human trials, the utility of cetyl myristoleate (derived from an esterified monounsaturated fatty acid) in promoting joint comfort was discovered in 1994 in experiments using rats. Celadrin Complex with Glucosamine also contains a prominent joint-supportive ingredient, glucosamine sulfate.
Research has shown that Celadrin can support knee range of motion and joint function. In a groundbreaking double-blind trial that took place at two clinics, 66 participants were randomized to receive either placebo or six capsules of a Celadrin complex (each containing 350 mg Celadrin) daily. Those participants taking the Celadrin complex for 2 months had significantly greater knee flexion (ability to bend the knee) over those taking placebo, in measurements taken at 30 and 68 days into the study.
Glucosamine sulfate (GS) has been the topic of intense and fruitful research into joint health over the past few decades. Levels of GS seen in the most acclaimed research are offered in Celadrin Complex with Glucosamine. In a recent meta-analysis of six studies involving 1,502 volunteers, it was determined that long-term daily supplementation with glucosamine sulfate (at 1,500 mg for at least 3 years) supported maintenance of knee joint structure over the years, compared to placebo. In a recent report, a British physician and joint health specialist concluded that, “Glucosamine has stood the test of time.”
Glucosamine sulfate (GS) supports joint function by supplying the body with dietary ingredients (glucosamine and sulfur) for building joint cartilage. Glucosamine, a monosaccharide that is essential to the glycosaminoglycans found in cartilage and synovial fluid, stimulates chondrocytes (cartilage cells) to manufacture cartilage building blocks known as proteoglycans. These building blocks contribute to the maintenance of sound joint structure, ultimately enhancing healthy joint function. Additionally, glucosamine inhibits unhelpful catabolic enzymes and can aid in the balance of interleukin-1ß levels in synovial fluid. A recent in vitro investigation examining the molecular biology of chondrocytes found 18 different proteins that were modulated by glucosamine sulfate. In conjunction with other studies, this new evidence suggests that GS fights cytokine-mediated oxidative stress in chondrocytes.
In Europe, implementation of glucosamine for joint health has been studied for four decades, including some of the most comprehensive clinical trials on this ingredient. A 3-year, randomized, placebo-controlled and double-blind study of 202 subjects concluded that glucosamine sulfate is safe and effective in both promoting joint function and maintaining joint structure.
In addition to its value in influencing joint structure, research also backs the ability of GS to influence joint comfort. A short-term (4-week) randomized, double-blind, parallel-group study of 200 subjects showed that GS taken orally can indeed promote comfortable joint function. Similar results were obtained from a multicenter, randomized, placebo-controlled, double-blind, parallel-group study of 252 subjects, where joint comfort in the knee was found to be higher in the GS group. More recently, a study of 318 subjects found 1,500 mg of GS daily to be more effective than placebo in enhancing joint comfort. Key among findings from these types of studies is the reoccurring theme of a good safety profile for glucosamine sulfate; reported “side effects” of GS were essentially no different than placebo.