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Doctor's Best - Best Glucosamine Chondroitin MSM - 240 Capsules

Maintains Healthy Joints & Connective Tissue!

Item #: 71553
MSRP: $46.99$24.99  you save 47% Per Serving: $0.21
Serving Size: 2.00Capsule(s)
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Doctor's Best - Best Glucosamine Chondroitin MSM - 240 Capsules

  • Code#:71553
  • Manufacturer:Doctor's Best
  • Size/Form:240  Capsules
  • Packaged Ship Weight:1
  • Servings:120
  • Dosage Size:2  Capsule(s)

Doctors Best - Glucosamine Chondroitin MSM 240 Capsules

Doctors Best Glucosamine Chondroitin MSM contains pure glucosamine sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of glucosamine, an amino sugar extracted from "chitin," a component of shellfish skeletons. ("Chitin," the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together.) The purified glucosamine is then sulfated and stabilized with potassium chloride.

Glucosamine sulfate is derived from the shells of ocean-growing shellfish. It is processed to remove all residues of protein and impurities, yielding pure glucosamine sulfate as the final material.

Glucosamine/Chondrotin/MSM contains chondroitin sulfate with a purity of 90 percent or greater. Quality assurance testing is performed using two sophisticated laboratory analysis methods: 1) HPLC and 2) C.P.C. Titration, a newly developed method now accepted as the most definitive test for chondroitin sulfate.

The MSM Story-One of Nature's Primary Sources of Organic Dietary Sulfur!
The human body requires a continuous supply of usable sulfur, and MSM is one of the primary organic sulfur-containing molecules for use by living organisms. From life's earliest beginnings, primitive marine organisms (blue-green algae and phytoplankton) have absorbed inorganic sulfur from ocean waters and produced organic sulfur molecules, primarily dimethyl sulfonium salts. These salts are released back into the sea, where they are converted to dimethyl sulfide, which readily evaporates, ending up in the upper atmosphere. Dimethyl sulfide is then oxidized by UV light, forming DMSO and MSM. The two compounds are delivered to land masses in rain water, and absorbed by plants. MSM is a stable end product of this process, serving as a primary source of sulfur in the food chain.

Supports Joint Structure, Function, and Comfort

The Roles of Glucosamine and Chondroitin Sulfate in Joints
Articular cartilage is a connective tissue composed of specialized cells (chondrocytes) embedded in a matrix of protein fibers (mostly collagen) and clusters of complex proteoglycan molecules that consist of a protein core with numerous side chains. These side chains, chiefly chondroitin sulfate and keratin sulfate, are long polysaccharide molecules called glycosaminoglycans. Chondroitin sulfate (CS) and the other glycosaminoglycans strongly attract water due to the negative charges of their sulfate groups. These negative charges also repel each other, creating spaces between glycosaminoglycan side chains where water can enter. This combination of solid and liquid gives cartilage a compressible quality that allows it to function as a shock absorber for joints.

Glucosamine is a fundamental building block for proteoglycans and glycosaminoglycans. Glucosamine sulfate (GS) helps to maintain joint health through its ability to both act as a component of and stimulate formation of cartilage glycosaminoglycans and the hyaluronic acid backbone essential for the formation of cartilage proteoglycans.

The Abundant Evidence Behind Glucosamine and Chondroitin Sulfate
Extensive joint health research over the past few decades has investigated the effects of glucosamine sulfate, chondroitin sulfate, or a combination of the two. A 2009 meta-analysis summarized results from 6 well-designed studies involving a total of 1,502 research participants. The authors of this meta-analysis were able to make some conclusions about the apparent effectiveness of long-term oral supplementation with CS or GS. Glucosamine sulfate at 1,500 mg daily over a period of at least 3 years and chondroitin sulfate at 800 mg daily over a period of at least 2 years both helped subjects maintain healthy knee cartilage structure.  In a 2008 review of GS & CS used for joint support, the London physician who wrote it concludes that, “Glucosamine, chondroitin, and the combination of these two agents have stood the test of time.”

Glucosamine sulfate is one of the most important—and thoroughly researched—dietary supplements for joint health ever developed.  In addition to its potential to influence joint structure (and thus function), research also backs the ability of GS to influence joint comfort. In one such multicenter, randomized, double-blind, parallel-group study of 252 subjects, joint comfort in the knee was found to be higher in the glucosamine sulfate group than the placebo group. Similar studies of equal magnitude found that GS enhanced joint comfort. Key among findings from these types of studies is the reoccurring theme of a good safety profile for glucosamine sulfate; reported “side effects” of GS were essentially no different than placebo.

Similar to glucosamine, chondroitin sulfate is known to influence the maintenance of healthy cartilage—in this case by acting on matrix metalloproteases (MMPs). Chondroitin sulfate has been shown to inhibit MMP-3 synthesis, which plays an important role in homeostasis of cartilage proteoglycans. Additionally, CS can downplay MMP-13 in chondrocytes, helping to maintain the integrity of articular cartilage matrix.

Clinical Trials Explore MSM’s Joint Action
Results from a randomized, double-blind, placebo-controlled pilot trial examining the effect of MSM supplementation on joint comfort in 50 men and women are promising. Subjects taking OptiMSM™ methylsulfonylmethane for 12 weeks experienced greater joint comfort than those taking placebo, suggesting potential for MSM as a joint support nutrient that warrants further investigation in larger clinical trials.  MSM also produced statistically significant changes in urinary malondialdehyde, a marker of oxidative stress.

MSM has also been used in combination with glucosamine to study their impact on the health of joints. In one such study, a total of 118 subjects were randomized into one of four groups for 12 weeks: glucosamine (500 mg three times daily), MSM (500 mg three times daily), the combination of glucosamine and MSM, or a placebo treatment. Glucosamine alone and MSM alone were shown to enhance joint function, while the combination was found to be even more effective, by both subjective and objective measurements.


Doctor's Best - Glucosamine Chondroition MSM - 240 Capsules
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 120 Servings
Amount Per Serving %DV**
Chloride (from glucosamine sulfate 2KCI) 84 mg 2%
Sodium (from chondroitin sulfate sodium) 28 mg 1%
Potassium (from glucosamine sulfate 2KCI) 91 mg 3%
Glucosamine sulfate 2KCI 750 mg  
Chondroitin sulfate
     (from condroitin sulfate sodium)
600 mg  
Methylsulfonylmethane
    OptiMSM
500 mg  

**Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs.
Daily Value Not Established.

Other Ingredients: cellulose, magnesium stearate (vegetable source), gelatin capsule

Average Rating

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Recommendation

100%16 out of 16 reviewers would recommend this product to a friend.
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By Edward (Florence , AL )

works good.

I RECOMMEND THIS PRODUCT!
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By Gerry (Whittier , CA )

I especially like this product as it is capsules rather than tablets

I RECOMMEND THIS PRODUCT!
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By jim (Cypress , TX )

Quality product. Good price.

I RECOMMEND THIS PRODUCT!
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By Linda

I have severe knee problem, my cartilage was practically none existent, talk about mice in my knees!. I had a lot of pain and my knees would lock up frequently with excruciating pain. I started taking Doctors best Glucosamine Chondroitin with MSM, having tried many other products without results. I am not saying that Doctors Best works for everyone. It does for me. I have been pain free for over twenty years. Thank you for keeping the price affordable

I RECOMMEND THIS PRODUCT!
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By Guy (Addis , LA )

I feel much better with this

I RECOMMEND THIS PRODUCT!
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Disclaimer: The views and opinions expressed by contributors of the product reviews are their own and not necessarily those of LuckyVitamin.com. LuckyVitamin.com does not endorse or imply any medical claims from these reviews. These reviews should not be taken as recommendations but rather customer opinions of the products that they may or may not have used. Reviews are not intended as a substitute for appropriate medical care or advice and are not intended to diagnose, treat, cure, or prevent any disease. Read the full product reviews disclaimer here.

Manufacturer Info

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197 Avenida La Pata
San Clemente, CA,
Phone: 949-498-3628 Fax: 949-498-3952 Visit website

About Doctor's Best

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Each of their products is accompanied by an annotated "fact sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

*The products and the claims made about specific products on or through this site have not been evaluated by LuckyVitamin.com or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.

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