Licorice

Also indexed as:Glycyrrhiza glabra, Glycyrrhiza uralensis, Licorice Root
Licorice: Main Image © Steven Foster
Botanical names:
Glycyrrhiza glabra, Glycyrrhiza uralensis

Side Effects

Licorice products that include glycyrrhizin may increase blood pressure and cause water retention and potassium deficiency.161 Some people are more sensitive to this effect than others. Long-term intake (more than two to three weeks) of products containing more than 1 gram of glycyrrhizin (the amount in approximately 10 grams of root) daily is the usual amount required to cause these effects. Consumption of 7 grams licorice (containing 500 mg glycyrrhizin) per day for seven days has been shown to decrease serum testosterone levels in healthy men by blocking the enzymes needed to synthesize testosterone.162 However, in another study, a similar amount of licorice had only a small and statistically insignificant effect on testosterone levels.163 As a result of these possible side effects, long-term intake of high levels of glycyrrhizin is discouraged and should only be undertaken if prescribed by a qualified healthcare professional. Consumption of plenty of fresh fruits and vegetables to increase potassium intake is recommended to help decrease the chance of potassium deficiency. According to the German Commission E monograph, licorice is inadvisable for pregnant women as well as for people with liver and kidney disorders.164

De-glycyrrhizinated licorice extracts usually do not cause these side effects since 97% of the glycyrrhizin has been removed.

Copyright © 2014 Aisle7. All rights reserved. Aisle7.com

Learn more about Aisle7, the company.

Learn more about the authors of Aisle7 products.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.